Patents by Inventor Dieter E. Jenne

Dieter E. Jenne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostic method, diagnostic reagent and therapeutic preparation for diseases caused by variation in LKB1 gene
    Patent number: 6800436
    Abstract: With respect to a range of 1.5 Mbp and more in the chromosome 19p13.3 region containing Peutz-Jeghers gene, a continuous cosmid contig is constructed and a restriction map is prepared. Next, genes mapped with this region are searched by using EST database and the locations of these genes are accurately determined. Based on the evaluation of biological data, etc., several highly likely candidates for Peutz-Jeghers genes are specified from the genes thus found. After successively analyzing variations in these genes in DNAs of patients with Peutz-Jeghers syndrome, it is found that one of these genes, i.e., “LKB1” has been specifically varied in these patients. Thus, the diseases caused by the variation in the LKB1 gene can be diagnosed and treated by using the LKB1 gene, primers and probes based on its base sequence, LKB1 protein, an antibody biding to this protein, etc.
    Type: Grant
    Filed: May 25, 2000
    Date of Patent: October 5, 2004
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Dieter E. Jenne, Jun-ichi Nezu
  • LKB1 gene knockout mice
    Patent number: 6791006
    Abstract: A mammal is provided, in which the LKB1 gene can be deleted phase-specifically and tissue-specifically. These mammals are highly useful as tools to reveal the onset mechanism for diseases caused by LKB1 gene deficiency, such as Peutz-Jeghers syndrome and cancers, as well as to develop therapeutic agents, methods, and so on for the diseases.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: September 14, 2004
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Jun-Ichi Nezu, Asuka Ose, Kou-Ichi Jishage, Dieter E. Jenne
  • LKB1 gene knockout animals
    Publication number: 20020166137
    Abstract: A mammal is provided, in which the LKB1 gene can be deleted phase-specifically and tissue-specifically. These mammals are highly useful as tools to reveal the onset mechanism for diseases caused by LKB1 gene deficiency, such as Peutz-Jeghers syndrome and cancers, as well as to develop therapeutic agents, methods, and so on for the diseases.
    Type: Application
    Filed: November 30, 2001
    Publication date: November 7, 2002
    Inventors: Jun-Ichi Nezu, Asuka Ose, Kou-Ichi Jishage, Dieter E. Jenne