Abstract: Blood purification device having an extracorporeal blood circuit with a blood inflow and outflow to and from a dialysis unit, wherein the dialysis unit comprises a dialysis solution inflow and a dialysate outflow, characterized by a control loop for control of the acid-base equilibrium of the blood, wherein bicarbonate is supplied to the blood using an aqueous bicarbonate-containing solution, wherein a measuring means for measuring a blood buffer parameter is associated with the control loop, wherein the blood buffer parameter is selected from one of bicarbonate concentration and CO2 partial pressure, and wherein a signal corresponding to the measured value of the blood buffer parameter can be supplied to a closed-loop control apparatus, which regulates the value of the blood buffer parameter by the supply of bicarbonate, and at least one pH-measuring means, wherein a signal corresponding to the pH value can be supplied to an alarm apparatus.

Abstract: Embodiments of the invention relate to an extracorporeal perfusion apparatus comprising an extracorporeal blood circuit for conveying blood, a filtrate circuit for conveying blood plasma, and a controller, wherein the filtrate circuit is connected to the extracorporeal blood circuit by means of a filter, wherein the filter has a sieving coefficient of 5% for substances having a molar mass of 340,000 g/mol (relative molecular mass of 340 kDa), and wherein a depletion agent comprising a first carrier having a neutral, hydrophobic surface is arranged in the filtrate circuit, wherein the perfusion apparatus comprises a dispensing means for feeding an endotoxin-binding lipopeptide into the extracorporeal blood circuit, wherein the endotoxin-binding lipopeptide is selected from the group consisting of polymyxins, polymyxin derivatives, prodrugs thereof, and a combination thereof.

Abstract: The invention relates to a sorption agent for removing endotoxins from a biological fluid, comprising a water-insoluble, porous carrier having a neutral hydrophobic surface wherein the surface of the carrier has an adsorptive coating made of polymyxin and albumin, wherein polymyxin and albumin are bonded to the surface of the carrier in a noncovalent manner. The invention further relates to a method for producing such a sorption agent. The sorption agent is used in extracorporeal blood purification, in particular in order to treat individuals, who have sepsis.

Abstract: The invention relates to a sorption agent having improved selectivity properties for removing protein-bound substances from a biological fluid, in particular blood or blood plasma of patients having severe disturbances of the liver function or liver failure and having kidney insufficiency, thee sorption agent having: (a) a porous, neutral, hydrophobic polymer and (b) a polypeptide layer adsorbed on the polymer, the neutral, hydrophobic polymer having a mean pore size of at least 15 nm. Furthermore, the invention relates to methods and uses in connection with such a sorption agent. The invention is used in particular in extracorporeal liver support.

Abstract: The invention relates to a device for the citrate anti-coagulated extracorporeal blood purification comprising: an extracorporeal blood purification system comprising an extracorporeal blood circuit (202), which comprises a dialysis unit (205), a blood inflow (203) and a blood discharge (204), a citrate metering device (212) for supplying citrate at a citrate supply point (213) upstream of the dialysis unit (205), a substitution medium metering device (214) for supplying a substitution medium at a substitution medium supply point (215) downstream from the dialysis unit (205), at least one ion concentration measuring means (224) for measuring bivalent cations and a controller (225), wherein the controller (225) is adapted to regulate the metering of the substitution medium as a function of a comparison between a setpoint value range and the ion concentration measured by means of the ion concentration measuring means (224), wherein the ion concentration measuring means (224) is adapted for the continuous gener

Abstract: Embodiments of the invention relate to an extracorporeal perfusion apparatus comprising an extracorporeal blood circuit for conveying blood, a filtrate circuit for conveying blood plasma, and a controller, wherein the filtrate circuit is connected to the extracorporeal blood circuit by means of a filter, wherein the filter has a sieving coefficient of 5% for substances having a molar mass of 340,000 g/mol (relative molecular mass of 340 kDa), and wherein a depletion agent comprising a first carrier having a neutral, hydrophobic surface is arranged in the filtrate circuit, wherein the perfusion apparatus comprises a dispensing means for feeding an endotoxin-binding lipopeptide into the extracorporeal blood circuit, wherein the endotoxin-binding lipopeptide is selected from the group consisting of polymyxins, polymyxin derivatives, prodrugs thereof, and a combination thereof.

Abstract: The invention relates to an endotoxin-binding lipopeptide selected from the group consisting of polymyxins, polymyxin derivatives, polymyxin analogues, prodrugs thereof and pharmaceutically acceptable salts thereof, and also relates to a preparation for parenteral administration comprising a lipopeptide of this type, for prophylaxis or for treatment of diseases and conditions caused by endotoxemia, by i) parenterally administering a bolus of the lipopeptide to achieve a lipopeptide serum concentration of 0.01 ?g/ml to 0.8 ?g/ml and ii) maintaining this lipopeptide serum concentration by parenterally administering the lipopeptide over a specifiable period of time.

Abstract: Embodiments of the invention relate to an extracorporeal perfusion apparatus comprising an extracorporeal blood circuit for conveying blood, a filtrate circuit for conveying blood plasma, and a controller, wherein the filtrate circuit is connected to the extracorporeal blood circuit by means of a filter, wherein the filter has a sieving coefficient of 5% for substances having a molar mass of 340,000 g/mol (relative molecular mass of 340 kDa), and wherein a depletion agent comprising a first carrier having a neutral, hydrophobic surface is arranged in the filtrate circuit, wherein the perfusion apparatus comprises a dispensing means for feeding an endotoxin-binding lipopeptide into the extracorporeal blood circuit, wherein the endotoxin-binding lipopeptide is selected from the group consisting of polymyxins, polymyxin derivatives, prodrugs thereof, and a combination thereof.

Abstract: Blood purification device (100,200) having an extracorporeal blood circuit (102,202) with a blood inflow (103,203) to a dialysis unit (105,205) for blood removed from a patient and a blood outflow (104,204) from the dialysis unit (105,205) for blood being guided back into the patient, wherein the dialysis unit (105,205) comprises an inflow (107,207) for a dialysis solution and a dialysate outflow (108,208), characterised by a control loop for closed-loop control of the acid-base equilibrium of the blood, wherein bicarbonate is supplied to the blood by means of an aqueous bicarbonate-containing solution, wherein at least one measuring means (124,124a,224,224a) for measuring a blood buffer parameter is associated with the control loop, wherein the blood buffer parameter is selected from the group consisting of bicarbonate concentration and CO2 partial pressure, and wherein a signal corresponding to the measured actual value of the blood buffer parameter can be supplied to a closed-loop control apparatus (125,22

Abstract: The invention relates to a sorption agent for removing endotoxins from a biological fluid, comprising a water-insoluble, porous carrier having a neutral hydrophobic surface wherein the surface of the carrier has an adsorptive coating made of polymyxin and albumin, wherein polymyxin and albumin are bonded to the surface of the carrier in a noncovalent manner. The invention further relates to a method for producing such a sorption agent. The sorption agent is used in extracorporeal blood purification, in particular in order to treat individuals, who have sepsis.

Abstract: The invention relates to a sorption agent for removing endotoxins from a biological fluid, the sorption agent having a water-insoluble, porous carrier and polymyxin, which is immobilized on the carrier, the carrier having a neutral, hydrophobic surface and polymyxin being immobilized on the surface of the carrier via hydrophobic interaction. The sorption agent is used in extracorporeal blood purification, in particular for treating individuals with sepsis.

Abstract: The invention relates to a sorption agent having improved selectivity properties for removing protein-bound substances from a biological fluid, in particular blood or blood plasma of patients having severe disturbances of the liver function or liver failure and having kidney insufficiency, the sorption agent having: (a) a porous, neutral, hydrophobic polymer and (b) a polypeptide layer adsorbed on the polymer, the neutral, hydrophobic polymer having a mean pore size of at least 15 nm. Furthermore, the invention relates to methods and uses in connection with such a sorption agent. The invention is used in particular in extracorporeal liver support.

Abstract: The invention relates to a device for the citrate anti-coagulated extracorporeal blood purification comprising: an extracorporeal blood purification system comprising an extracorporeal blood circuit (202), which comprises a dialysis unit (205), a blood inflow (203) and a blood discharge (204), a citrate metering device (212) for supplying citrate at a citrate supply point (213) upstream of the dialysis unit (205), a substitution medium metering device (214) for supplying a substitution medium at a substitution medium supply point (215) downstream from the dialysis unit (205), at least one ion concentration measuring means (224) for measuring bivalent cations and a controller (225), wherein the controller (225) is adapted to regulate the metering of the substitution medium as a function of a comparison between a setpoint value range and the ion concentration measured by means of the ion concentration measuring means (224), wherein the ion concentration measuring means (224) is adapted for the continuous genera

Abstract: The present invention is directed to an arrangement for the elimination of substances by means of a membrane filter wherein the use is foreseen both in the blood cleaning procedures as well as in chemical and biotechnological separation techniques. The fluid containing the substances is run through the primary side of the membrane filter and the secondary side is flowed through by a adsorptive suspension which contains the substance binding particles. A pump drives the adsorptive suspension through the secondary side of membrane filter and causes in this way locally differentiable positive and negative transmembrane pressure differences whereby a local fluid exchange occurs and by means of which the active substances come into contact with the particles. Since the volume of the adsorptive suspension in the secondary circuit is held constant, the mean transmembrane pressure does not alter.