Patents by Inventor Dieter H. Klaubert

Dieter H. Klaubert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-Benzyl and N-substituted benzyl tetrazole-5-carboxylic acids and the preparation thereof
    Patent number: 4316037
    Abstract: N-Protected-tetrazole-5-carboxylic acid derivatives of the formula: ##STR1## in which R is --OM, halo or lower alkoxy wherein M is hydrogen, an alkali metal or an alkaline earth metal; andR.sub.1 is phenyl, 4-methoxyphenyl, 2,4-dimethoxyphenyl or 2,4,6-trimethoxyphenyl,are produced by addition of R.sub.1 --CH.sub.2 --N.sub.3 to a lower alkyl cyanoformate followed by saponification, optional acidification, and conversion to the carbonyl halide. The N-protected tetrazole-5-carbonylhalides are intermediates for the production of anti-allergic agents.
    Type: Grant
    Filed: January 21, 1977
    Date of Patent: February 16, 1982
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Dieter H. Klaubert
  • (1H-Imidazol-5-ylmethyl)isothioureas
    Patent number: 4262125
    Abstract: Anti-secretory, anti-hypertensive agents of the formula are presented: ##STR1## in which R is alkyl of 1 to 6 carbon atoms;R.sub.1 is hydrogen or alkyl of 1 to 6 carbon atoms;R.sub.2 is hydrogen, alkyl of 1 to 6 carbon atoms; phenyl, ##STR2## wherein R.sub.3 and R.sub.4 are independently hydrogen, alkyl of 1 to 6 carbon atoms alkoxy of 1 to 6 carbon atoms, or --CH.sub.3, or R.sub.2 and R.sub.1 taken together are ethylene or tetramethylene;or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: July 23, 1979
    Date of Patent: April 14, 1981
    Assignee: American Home Products Corporation
    Inventor: Dieter H. Klaubert
  • Antisecretory oxamic acid esters
    Patent number: 4209528
    Abstract: Variously substituted oxanilic acid esters possessing anti-secretory activity are useful anti-ulcer agents.
    Type: Grant
    Filed: January 5, 1979
    Date of Patent: June 24, 1980
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Charles J. Guinosso, Dieter H. Klaubert, David A. Shriver
  • Antisecretory oxamic acid esters
    Patent number: 4137325
    Abstract: Variously substituted oxanilic acid esters possessing anti-secretary activity are useful anti-ulcer agents.
    Type: Grant
    Filed: March 17, 1977
    Date of Patent: January 30, 1979
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Charles J. Guinosso, David A. Shriver, Dieter H. Klaubert
  • Process for preparing tetrazole-5-carboxamide derivatives
    Patent number: 4129735
    Abstract: Anti-allergic agents of N-aromatic 1H-(or 2H) tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which R.sup.1 is --CN or --CONH.sub.2 ;R.sup.2 is hydrogen, lower alkyl, lower alkoxy, halo, polyhalo(lower)alkyl, lower alkyl carbonyl or carb(lower)alkoxy;X is ##STR2## where R.sup.3 is lower alkyl and R.sup.4 is hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 24, 1976
    Date of Patent: December 12, 1978
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Dieter H. Klaubert
  • Tetrazole-5-carboxamide derivatives
    Patent number: 4123432
    Abstract: Anti-allergic agents of N-aromatic 1H-(or 2H) tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which R.sup.1 is --CN or --CONH.sub.2 ;R.sup.2 is hydrogen, lower alkyl, lower alkoxy, halo, polyhalo(lower)alkyl, lower alkyl carbonyl or carb(lower)alkoxy;X is --CH.sub.2 --, --O--, or ##STR2## where R.sup.3 is lower alkyl; and R.sup.4 is hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 23, 1977
    Date of Patent: October 31, 1978
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Dieter H. Klaubert
  • Tetrazole-5-carboxamide derivatives
    Patent number: 4116960
    Abstract: Anti-allergic agents of N-aromatic 1H-(or 2H) tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which R.sup.1 is --CN or --CONH.sub.2 ;R.sup.2 is hydrogen, lower alkyl, lower alkoxy, halo, polyhalo(lower)alkyl, lower alkyl carbonyl or carb(lower)alkoxy;X is --CH.sub.2 --, --O-- ##STR2## where R.sup.3 is lower alkyl and R.sup.4 is hydrogen or lower alkyl;Or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 24, 1976
    Date of Patent: September 26, 1978
    Assignee: American Home Products Corporation
    Inventors: John M. Sellstedt, Dieter H. Klaubert
  • Arylene-bis-tetrazole-5-carboxamides
    Patent number: 4096153
    Abstract: Anti-allergic agents of N,N'-arylene-bis-tetrazole-5-carboxamide derivation, pharmaceutically acceptable salts thereof and N-protected intermediates therefor.
    Type: Grant
    Filed: January 21, 1977
    Date of Patent: June 20, 1978
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Dieter H. Klaubert
  • 2-Cyano-3- or 4-(substituted amino)oxanilic acid derivatives
    Patent number: 4087606
    Abstract: The 2-cyano-3-or 4-(substituted amino) oxanilic acid derivatives of the formula: ##STR1## in which the group ##STR2## appears in the designated 3- or 4- position and R is --H; an alkali metal; .sup.+ NH.sub.4 ; alkyl of 1 to 6 carbon atoms, inclusive; aralkyl of 7 or 8 carbon atoms; or cycloalkyl of 5 or 6 carbon atoms;R.sup.1 is --H or alkyl of 1 to 9 carbon atoms;R.sup.2 is --H, alkyl of 1 to 9 carbon atoms or cycloalkyl of 3 to 6 carbon atoms;R.sup.1 and R.sup.2, together, with the nitrogen atom to which they are attached, are aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, 4-lower alkyl-piperazinyl, morpholino or thiomorpholino;And pharmaceutically acceptable acid addition salts thereof are anti-allergic agents.
    Type: Grant
    Filed: May 26, 1977
    Date of Patent: May 2, 1978
    Assignee: American Home Products Corporation
    Inventors: Dieter H. Klaubert, John H. Sellstedt, Charles J. Guinosso
  • 2,6-Pyridinediyl-bis-tetrazol-5-carboxamides
    Patent number: 4076718
    Abstract: Anti-allergic agents of N,N'-(2,6-pyridinediyl)bis(1H-tetrazole-5-carboxamide derivation, pharmaceutically acceptable salts thereof and N-protected intermediates therefor.
    Type: Grant
    Filed: January 21, 1977
    Date of Patent: February 28, 1978
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Dieter H. Klaubert
  • Method of treatment using tetrazole-5-carboxamide derivatives
    Patent number: 4057632
    Abstract: Anti-allergic agents of N-aromatic 1H-(or 2H) tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which R.sup.1 is --CN or --CONH.sub.2 ;R.sup.2 is hydrogen, lower alkyl, lower alkoxy, halo, polyhalo(lower)alkyl, lower alkyl carbonyl or carb(lower)alkoxy;X is --CH.sub.2 --, ##STR2## where R.sup.3 is lower alkyl and R.sup.4 is hydrogen or lower alkyl;Or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 24, 1976
    Date of Patent: November 8, 1977
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Dieter H. Klaubert
  • 2-Cyano-3-or 4-(substituted amino)oxanilic acid derivatives
    Patent number: 4054591
    Abstract: The 2-cyano-3-or 4-(substituted amino)oxanilic acid derivatives of the formula: ##STR1## in which the group ##STR2## appears in the designated 3- or 4- position and R is -H; an alkali metal; .sup.+ NH.sub.4 ; alkyl of 1 to 6 carbon atoms, inclusive; aralkyl of 7 or 8 carbon atoms; or cycloalkyl of 5 or 6 carbon atoms;R.sup.1 is --H or alkyl of 1 to 9 carbon atoms;R.sup.2 is --H, alkyl of 1 to 9 carbon atoms or cycloalkyl of 3 to 6 carbon atoms;R.sup.1 and R.sup.2, together, with the nitrogen atom to which they are attached, are aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, 4-lower alkyl-piperazinyl, morpholino or thiomorpholino; and pharmaceutically acceptable acid addition salts thereof are anti-allergic agents.
    Type: Grant
    Filed: August 4, 1976
    Date of Patent: October 18, 1977
    Assignee: American Home Products Corporation
    Inventors: Dieter H. Klaubert, John H. Sellstedt, Charles J. Guinosso
  • Morpholine containing tetrazole-5-carboxamide derivatives
    Patent number: 4013647
    Abstract: Anti-allergic agents of N-aromatic 1H-(or 2H) tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which R.sup.1 is --CN or --CONH.sub.2 ;R.sup.2 is hydrogen, lower alkyl, lower alkoxy, halo, polyhalo(lower)alkyl, lower alkyl carbonyl or carb(lower)alkoxy;X is --CH.sub.2 --, ##STR2## where R.sup.3 is lower alkyl and R.sup.4 is hydrogen or lower alkyl;Or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 23, 1976
    Date of Patent: March 22, 1977
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Dieter H. Klaubert
  • (4-Oxo-4H-1-benzopyran-2-yl)-oxamic acid, salts and esters anti-allergic agents
    Patent number: 3937719
    Abstract: Anti-allergic agents present the following structural formula: ##SPC1##In whichR is --H, lower alkyl or an alkali metal cation.R.sup.2 is alkyl of 1 to 6 carbon atoms or hydroxyalkyl of 2 to 6 carbon atoms.
    Type: Grant
    Filed: January 6, 1975
    Date of Patent: February 10, 1976
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Dieter H. Klaubert