Abstract: A system for reducing toxicity from intravascular triggered drug delivery includes a chamber comprising an inflow port, an outflow port, and a filter positioned upstream of the outflow port. A trigger module is configured to trigger the release of a drug from an intravascular triggered drug delivery system present in blood in the chamber. A method for reducing toxicity from intravascular triggered drug delivery includes the steps of removing blood comprising an intravascular triggered drug delivery system from a patient's vascular system and delivering the blood to a chamber, applying a trigger to the blood to release a drug from the intravascular triggered drug delivery system, filtering the drug from the blood, and returning the filtered blood to the patient.

Abstract: A system for reducing toxicity from intravascular triggered drug delivery includes a chamber comprising an inflow port, an outflow port, and a filter positioned upstream of the outflow port. A trigger module is configured to trigger the release of a drug from an intravascular triggered drug delivery system present in blood in the chamber. A method for reducing toxicity from intravascular triggered drug delivery includes the steps of removing blood comprising an intravascular triggered drug delivery system from a patient's vascular system and delivering the blood to a chamber, applying a trigger to the blood to release a drug from the intravascular triggered drug delivery system, filtering the drug from the blood, and returning the filtered blood to the patient.

Abstract: An electrode array supports multiple electrodes and energizes them so that adjacent electrodes do not have the same polarity. In one embodiment, the electrodes are held about a circumference outside and surrounding a tumor and opposed electrodes are energized in a round robin fashion to promote current flow through the center of the tumor from a variety of angles.

Abstract: Methods for quantitative perfusion analysis for embolotherapy are presented. The method quantitatively measures blood flow changes based on angiographic information. The method may provide potential evaluation of optimal embolization endpoints in vascular vessels. The method may be used in various applications such as transcatheter arterial chemoembolization (TACE), or other medical procedures that affect blow flow within bodily tissues. The method is applicable towards treatment of tumors in liver, kidney, brain, and other organs.

Abstract: Efficient ablation with multiple electrodes is obtained by rapidly switching electric power to the electrodes. In this way, shielding effects caused by the field around each electrode which would otherwise create cool spots, are avoided. Complex inter-electrode current flows are also avoided.

Abstract: Embodiments of the invention comprise methods and devices that allow quantification of blood convective cooling at the cardiac RF catheter ablation site and allow for prediction of lesion size and/or computation of RF energy parameters and characteristics.

Abstract: Embodiments of the invention comprise methods and devices that allow quantification of blood convective cooling at the cardiac RF catheter ablation site and allow for prediction of lesion size and/or computation of RF energy parameters and characteristics.

Abstract: An electrode array supports multiple electrodes and energizes them so that adjacent electrodes do not have the same polarity. In one embodiment, the electrodes are held about a circumference outside and surrounding a tumor and opposed electrodes are energized in a round robin fashion to promote current flow through the center of the tumor from a variety of angles.

Abstract: An electrode array allows for rapid ablation of a strip of tissue in an organ providing a barrier to blood loss during resection operations.

Abstract: A radiofrequency ablation device reduces the incidence of skin burns by selectively activating ground pads in a partially sequential and partially contemporaneous manner. The selective sequential activation of the ground pads lowers power dispersion at each ground pad relative to contemporaneous activation of ground pads and/or sequential activation of ground pads. This reduction in power dispersion at each ground pad consequently yields a lower overall maximum temperature, and more uniform heating of all of the ground pads. This makes the system more predictable and safer for use in treatment. The radiofrequency ablation device may include a layered ground pad that includes at least two layers of material. One layer of material can be substantially similar to the material used for a monolithic ground pad, and one layer can have a substantially lower relative electrical conductivity, but a substantially higher electrical conductivity relative to adjacent body tissue.

Abstract: A radiofrequency ablation system provides multiple ground pads and active control of current flow through the ground pads to provide improved power sharing at the tissue near the ground pads reducing risk of patient skin burns for higher power ablation generators.

Abstract: Embodiments of the invention comprise methods and devices that allow quantification of blood convective cooling at the cardiac RF catheter ablation site and allow for prediction of lesion size and/or computation of RF energy parameters and characteristics.

Abstract: An electrode array allows for rapid ablation of a strip of tissue in an organ providing a barrier to blood loss during resection operations.

Abstract: Efficient ablation with multiple prong electrodes is obtained by electrically isolating the prongs from each other and rapidly switching electric power between the prongs, between a prong and a ground pad, or both. In this way, power distribution to a tumor can be controlled efficiently without the need to change probe geometry.

Abstract: In radiofrequency ablation, larger lesion volumes are obtained for a given energy delivery by energizing at least two electrodes on either side of the tumor so that current is focused between them rather than dispersed radially to a large area ground plate. Modified standard umbrella probes may be used or a specialized dual electrode array may be fabricated for simplified use. Differential impedance between tumor and non-tumor tissues at certain frequencies is exploited to further improve lesion shape and size.

Abstract: Efficient ablation with multiple electrodes is obtained by rapidly switching electric power to the electrodes. In this way, shielding effects caused by the field around each electrode which would otherwise create cool spots, are avoided. Complex inter-electrode current flows are also avoided.

Abstract: In radio frequency ablation, larger lesion volumes are obtained for a given energy delivery by energizing at least two electrodes on either side of the tumor so that current is focused between them rather than dispersed radially to a large area ground plate. Modified standard umbrella probes may be used or a specialized dual electrode array may be fabricated for simplified use. Differential impedance between tumor and non-tumor tissues at certain frequencies is exploited to further improve lesion shape and size.