Patents by Inventor Dieter Mangold
Dieter Mangold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8202490Abstract: A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluids.Type: GrantFiled: April 19, 2011Date of Patent: June 19, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Juergen Klepp, Thomas Fischer, Rolf Lerch, Dieter Mangold, Juergen Schaeffler
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Patent number: 8137905Abstract: The invention relates to an apparatus and a method for determining an analyte in a fluid. Provided in the device is a stirring zone formed in an optionally microfluidic three-dimensional structure, into which stirring zone a sample of the fluid can be introduced and in which there is a stirring device which can be operated in a contactless manner and is optionally designed as a microstirrer, the stirring device being configured so as to stir the sample of fluid introduced into the stirring zone and being loaded with at least one reagent which reacts with the analyte. The invention also provides a stirring device which can be operated in a contactless manner and is optionally designed as a microstirrer, the stirring device being loaded with the at least one reagent which reacts with the analyte.Type: GrantFiled: January 4, 2008Date of Patent: March 20, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Michael Brauner, Thomas Kotnig, Dieter Mangold, Norbert Oranth, Christoph Ritter, Gerd Schweiger, Valerie Winckler-Desprez
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Publication number: 20110194980Abstract: A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluids.Type: ApplicationFiled: April 19, 2011Publication date: August 11, 2011Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Juergen Klepp, Thomas Fischer, Rolf Lerch, Dieter Mangold, Juergen Schaeffler
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Patent number: 7955563Abstract: A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluid.Type: GrantFiled: June 6, 2007Date of Patent: June 7, 2011Assignee: Roche Diagnostics Operations, Inc.Inventors: Juergen Klepp, Thomas Fischer, Rolf Lerch, Dieter Mangold, Juergen Schaeffler
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Patent number: 7641862Abstract: An analytical test element for blood analyses is provided having an application site and a microfluidic channel structure in fluid communication with the application site. The channel structure includes at least first and second analytical channels for receiving first and second portions of a blood sample applied to the application site. The first analytical channel includes a first analytical site to determine the total haemoglobin value (Hb) of the blood sample. The second analytical channel includes a second analytical site to determine a glycohaemoglobin value (HbA1c) of the blood sample.Type: GrantFiled: December 9, 2008Date of Patent: January 5, 2010Assignee: Roche Diagnostics Operations, Inc.Inventors: Siegfried Noetzel, Jean-Philippe Bogardi, Dieter Mangold
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Publication number: 20090087901Abstract: An analytical test element for blood analyses is provided having an application site and a microfluidic channel structure in fluid communication with the application site. The channel structure comprises at least first and second analytical channels for receiving first and second portions of a blood sample applied to the application site. The first analytical channel comprises a first analytical site to determine the total haemoglobin value (Hb) of the blood sample. The second analytical channel comprises a second analytical site to determine a glycohaemoglobin value (HbA1c) of the blood sample.Type: ApplicationFiled: December 9, 2008Publication date: April 2, 2009Inventors: Siegfried Noetzel, Jean-Philippe Bogardi, Dieter Mangold
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Patent number: 7479393Abstract: An analytical test element for blood analyses is provided having at least a substrate body having a channel structure for the flow transport of a blood sample from an application site to at least one analytical site. The channel structure has a dilution channel that can be loaded with the blood sample and is provided with a separation component for retaining corpuscular blood components and has a sample channel which conveys a blood sample aliquot to be diluted and joins the dilution channel at a mixing site.Type: GrantFiled: February 6, 2004Date of Patent: January 20, 2009Assignee: Roche Diagnostics Operations, Inc.Inventors: Siegfried Noetzel, Jean-Philippe Bogardi, Dieter Mangold
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Publication number: 20080220539Abstract: The invention relates to an apparatus and a method for determining an analyte in a fluid. Provided in the device is a stirring zone formed in an optionally microfluidic three-dimensional structure, into which stirring zone a sample of the fluid can be introduced and in which there is a stirring device which can be operated in a contactless manner and is optionally designed as a microstirrer, the stirring device being configured so as to stir the sample of fluid introduced into the stirring zone and being loaded with at least one reagent which reacts with the analyte. The invention also provides a stirring device which can be operated in a contactless manner and is optionally designed as a microstirrer, the stirring device being loaded with the at least one reagent which reacts with the analyte.Type: ApplicationFiled: January 4, 2008Publication date: September 11, 2008Applicant: Roche Diagnostics Operations, Inc.Inventors: Michael Brauner, Thomas Kotnig, Dieter Mangold, Norbert Oranth, Christoph Ritter, Gerd Schweiger, Valerie Winckler-Desprez
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Publication number: 20070274861Abstract: A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluid.Type: ApplicationFiled: June 6, 2007Publication date: November 29, 2007Applicant: Roche Diagnostics Operations, Inc.Inventors: Juergen Klepp, Thomas Fischer, Rolf Lerch, Dieter Mangold, Juergen Schaeffler
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Publication number: 20040191124Abstract: For an analytical test element for blood analyses comprising a substrate body having a channel structure for the flow transport of a blood sample from an application site to at least one analytical site, the invention proposes that the channel structure has a dilution channel that can be loaded with the blood sample and is provided with separation means for retaining corpuscular blood components and has a sample channel which conveys a blood sample aliquot to be diluted and joins the dilution channel at a mixing site.Type: ApplicationFiled: February 6, 2004Publication date: September 30, 2004Inventors: Siegfried Noetzel, Jean-Philippe Bogardi, Dieter Mangold
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Patent number: 6153192Abstract: A peptide according to the present invention is not more than 40 amino acids long and contains a sequence which is at least 6 amino acids long from the amino acid partial sequence between the amino acids 144 and 183 of human .alpha.1-microglobulin or/and a sequence which is at least 6 amino acids long from the amino acid partial sequence between the amino acids 1 and 20 of human .alpha.1-microglobulin.An antibody according to the present invention is capable of specific binding to a peptide according to the present invention as well as to human .alpha.1-microglobulin.In order to determine human .alpha.1-microglobulin in a sample liquid by an immunoassay, the sample liquid is brought into contact simultaneously or sequentially with defined amounts of the components antibody and peptide whereby one of the components is labelled and the determination is carried out by means of this label.Type: GrantFiled: July 22, 1993Date of Patent: November 28, 2000Assignee: Boehringer Mannheim GmbHInventors: Erhard Kopetzki, Christian Klein, Dieter Mangold, Werner Stock, Reiner Schlipfenbacher
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Patent number: 5525480Abstract: The present invention provides N- and O-substituted aminophenol derivatives of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, G and L are as hereinbefore defined. The present invention also provides intermediates for the preparation of these aminophenol derivatives of general formula (I), as well as the use of the aminophenol derivatives of general formula (I) for the determination of hydrolases, as well as for the preparation of agents for carrying out determinations of hydrolysis.Type: GrantFiled: June 9, 1994Date of Patent: June 11, 1996Assignee: Boehringer Mannheim GmbHInventors: Gerd Zimmermann, Dieter Mangold
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Patent number: 5403706Abstract: A carrier matrix of polyvinyl alcohol-coated glass is dissolvably impregnated with reagent. The matrix is manufactured by slurrying glass fibers in an excess of water and polyvinyl alcohol and forming a layer, which is then dried and impregnated with reagent.Type: GrantFiled: July 20, 1989Date of Patent: April 4, 1995Assignee: Boehringer Mannheim GmbHInventors: Hans-Erich Wilk, Dieter Mangold, Rolf Lerch, Joachim Steinbiss
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Patent number: 5391482Abstract: The present invention is concerned with the use of 1-arylsemicarbazides of the general formula:Ar--NH--NH--CON.sub.2wherein Ar is an aryl radical optionally substituted by alkyl, alkoxy or halogen, for the stabilization of an enzyme substrate from which, by enzymatic hydrolysis, a leuko coloured material can be formed which, in turn, can be reacted by an oxidation agent to give a colored material. The present invention also provides a corresponding stabilizing process and a diagnostic agent containing such a stabilizer.Type: GrantFiled: December 21, 1990Date of Patent: February 21, 1995Assignee: Boehringer Mannheim GmbHInventor: Dieter Mangold
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Patent number: 5334505Abstract: The present invention provides N- and O-substituted aminophenol derivatives of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, G and L are as hereinbefore defined. The present invention also provides intermediates for the preparation of these aminophenol derivatives of general formula (I), as well as the use of the aminophenol derivatives of general formula (I) for the determination of hydrolyses, as well as for the preparation of agents for carrying out determinations of hydrolyses.Type: GrantFiled: December 21, 1990Date of Patent: August 2, 1994Assignee: Boehringer Mannheim GmbHInventors: Gerd Zimmermann, Dieter Mangold
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Patent number: 5310885Abstract: The present invention provides a process for immobilizing a protein or protein containing substance. The material to be immobilized is aggregated, contacted in a liquid with a hydrophilic solid phase and the solid phase, after contact has taken place, is dried. The present invention is also concerned with the solid phase prepared by this process and with the use thereof for analytical determination.Type: GrantFiled: May 19, 1992Date of Patent: May 10, 1994Assignee: Boehringer Mannheim GmbHInventors: Josef Maier, Dieter Mangold, Reiner Schlipfenbacher
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Patent number: 5306622Abstract: The invention teaches a method for determining an analyte in a liquid sample via a heterogeneous assay. The sample is contacted to a carrier material which contains, in addition to one of a labelled analyte analogous substance or a labelled analyte specific substance, a detectable component which does not influence immunological reactions occurring during the course of the assay. A solid phase bound component, which is either an insufficient amount of analyte specific substance or an excess of analyte relative to analyte in the sample is contacted to the sample so as to accomplish formation of solid phase bound complexes. After separation of liquid and solid phase, label is measured in one of these, and the detectable substance is measured in the liquid. Correlation of the values obtained leads to determination of the analyte. Also described is a reagent used in the described method.Type: GrantFiled: November 5, 1991Date of Patent: April 26, 1994Assignee: Boehringer Mannheim GmbHInventor: Dieter Mangold
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Patent number: 5296356Abstract: The invention concerns a method for the detection of an analyte in a sample liquid by an enzyme-immunoassay in which an enzyme-labelled compound is partitioned between a solid and a liquid phase and the amount of enzyme label in the liquid phase outside the solid phase is determined as a measure of the concentration of the analyte. The measurement is carried out in a non-porous molding having the liquid phase contained therein in contact with the solid phase. The method is particularly suitable for carrying out in a cuvette which can be filled via the porous matrix or on a test strip having a space in contact with the solid phase.Type: GrantFiled: December 12, 1990Date of Patent: March 22, 1994Assignee: Boehringer Mannheim GmbHInventors: Dieter Mangold, Ulrich Traeger, Hans Lange
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Patent number: 5188939Abstract: A method for carrying out competitive displacement immunoassays which entails the use of an oligovalent labelled antibody having at least 4 binding sites for the analyte to be determined per label.Type: GrantFiled: July 9, 1990Date of Patent: February 23, 1993Assignee: Boehringer Mannheim GmbHInventors: Dieter Mangold, Reiner Schlipfenbacher
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Patent number: 5177022Abstract: The present invention provides an immune reactive porous carrier material comprising a porous carrier material with immune complexes precipitated thereon, wherein the porous carrier material is treated with at least one wet-strength agent.The present invention also provides processes for the production of this immune reactive porous carrier material.Type: GrantFiled: August 25, 1988Date of Patent: January 5, 1993Assignee: Boehringer Mannheim GmbHInventors: Dieter Mangold, Siegfried Noetzel, Rolf Lerch, Jelmut Jering