Patents by Inventor Dieter Melzner
Dieter Melzner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11913949Abstract: The present invention relates to a multiparameter lateral flow strip (1), comprising a microporous membrane layer (2) supported on a liquid-impermeable support layer (3), for lateral flow of a liquid through the microporous membrane layer (2), wherein the microporous membrane layer (2) has two or more flow lanes (4) in the direction of lateral flow, wherein said two or more flow lanes (4) are separated by hydrophobic separation channels (5), and wherein each of said two or more flow lanes (4) comprises a detection spot (6) including a binding agent, wherein said two or more flow lanes (4) are isomorphic lanes. Furthermore, the present invention relates to a multiparameter lateral flow immunoassay device comprising said multiparameter lateral flow membrane (1), the use of said multiparameter configured lateral flow membrane (1) in an immunological test, as well as to a method for the manufacture of said multiparameter configured lateral flow membrane (1).Type: GrantFiled: April 28, 2015Date of Patent: February 27, 2024Assignee: Sartorius Stedim Biotech GmbHInventors: Denise Van Rossum, Eric Jallérat, Susanne Drebing, Dieter Melzner
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Patent number: 11313854Abstract: The present invention relates to a patterned membrane structure comprising a microporous membrane layer, wherein the microporous membrane layer includes a plurality of flow lanes, the flow lanes are separated by hydrophobic separation channels, and the flow lanes and hydrophobic separation channels form a repetitive pattern; and a method for manufacture of the patterned membrane structure. The patterned membrane structure according to the present invention represents an industrial scale precursor of membranes such as a multiparameter lateral flow membrane comprising separated flow lanes.Type: GrantFiled: July 19, 2016Date of Patent: April 26, 2022Inventors: Susanne Drebing, Alfons Kesting, Dieter Melzner, Denise Van Rossum
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Patent number: 11224843Abstract: The present invention relates to a crosslinked unreinforced cellulose hydrate membrane crosslinked using at least two different crosslinking agents, to a method for the production thereof and to the use of the crosslinked unreinforced cellulose hydrate membrane according to the invention.Type: GrantFiled: December 1, 2017Date of Patent: January 18, 2022Assignee: Sartorius Stedim Biotech GmbHInventors: Sandra Van Der Kruijs, Annette Reiche, Gabriel Nino-Amézquita, Louis Villain, Hans-Heinrich Hörl, Dieter Melzner, Franziska Bäthe
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Publication number: 20200230557Abstract: The present invention relates to a crosslinked unreinforced cellulose hydrate membrane crosslinked using at least two different crosslinking agents, to a method for the production thereof and to the use of the crosslinked unreinforced cellulose hydrate membrane according to the invention.Type: ApplicationFiled: December 1, 2017Publication date: July 23, 2020Inventors: Sandra Van Der Kruijs, Annette Reiche, Gabriel Nino-Amézquita, Louis Villain, Hans-Heinrich Hörl, Dieter Melzner, Franziska Bäthe
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Patent number: 10345314Abstract: The present invention relates to a lateral flow membrane arrangement (1), comprising a microporous membrane layer (2) and a liquid-impermeable support layer (3), for lateral flow of a liquid through the microporous membrane layer (2), wherein the microporous membrane layer (2) is supported on the liquid-impermeable support layer (3) and has at least one detection zone (5) and at least one non-detection zone, wherein binding agents are immobilized in the at least one detection zone (5), the liquid-impermeable support layer (3) has at least one zone having a large thickness and at least one zone having a small thickness, the microporous membrane layer (2) is supported on the liquid-impermeable support layer (3) such that said at least one detection zone is provided above said at least one zone of the support layer having a large thickness and said at least one non-detection zone is provided above said at least one zone of the support layer having a small thickness, the zones are oriented in a direction orthogonType: GrantFiled: April 29, 2014Date of Patent: July 9, 2019Assignee: SARTORIUS STEDIM BIOTECH GMBHInventors: Dieter Melzner, Denise Van Rossum
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Publication number: 20180328918Abstract: The present invention relates to a patterned membrane structure comprising a microporous membrane layer, wherein the microporous membrane layer includes a plurality of flow lanes, the flow lanes are separated by hydrophobic separation channels, and the flow lanes and hydrophobic separation channels form a repetitive pattern; and a method for manufacture of the patterned membrane structure. The patterned membrane structure according to the present invention represents an industrial scale precursor of membranes such as a multiparameter lateral flow membrane comprising separated flow lanes.Type: ApplicationFiled: July 19, 2016Publication date: November 15, 2018Inventors: Susanne DREBING, Alfons KESTING, Dieter MELZNER, Denise VAN ROSSUM
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Publication number: 20180143191Abstract: The present invention relates to a multiparameter lateral flow strip (1), comprising a microporous membrane layer (2) supported on a liquid-impermeable support layer (3), for lateral flow of a liquid through the microporous membrane layer (2), wherein the microporous membrane layer (2) has two or more flow lanes (4) in the direction of lateral flow, wherein said two or more flow lanes (4) are separated by hydrophobic separation channels (5), and wherein each of said two or more flow lanes (4) comprises a detection spot (6) including a binding agent, wherein said two or more flow lanes (4) are isomorphic lanes. Furthermore, the present invention relates to a multiparameter lateral flow immunoassay device comprising said multiparameter lateral flow membrane (1), the use of said multiparameter configured lateral flow membrane (1) in an immunological test, as well as to a method for the manufacture of said multiparameter configured lateral flow membrane (1).Type: ApplicationFiled: April 28, 2015Publication date: May 24, 2018Inventors: Denise Van Rossum, Eric Jallérat, Susanne Drebing, Dieter Melzner
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Patent number: 9891230Abstract: The present invention relates to a microarray device for the screening or the finding of protein inhibitors, to a method for the production thereof, and to a corresponding method for screening or finding protein inhibitors. The microarray device according to the invention comprises a solid supporting element having a support material, at least one protein immobilized thereon for which inhibitors are to be screened or found, and at least one known inhibitor of the at least one protein, the inhibitor being bound to the at least one protein and comprising a detectable label.Type: GrantFiled: April 20, 2012Date of Patent: February 13, 2018Assignee: SARTORIUS STEDIM BIOTECH GMBHInventors: Dieter Melzner, Thomas Scheper, Thomas Schueler, Frank Stahl, Denise Van Rossum, Johanna-Gabriela Walter, Carsten Zeilinger
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Publication number: 20160178640Abstract: The present invention relates to a lateral flow membrane arrangement (1), comprising a microporous membrane layer (2) and a liquid-impermeable support layer (3), for lateral flow of a liquid through the microporous membrane layer (2), wherein the microporous membrane layer (2) is supported on the liquid-impermeable support layer (3) and has at least one detection zone (5) and at least one non-detection zone, wherein binding agents are immobilized in the at least one detection zone (5), the liquid-impermeable support layer (3) has at least one zone having a large thickness and at least one zone having a small thickness, the microporous membrane layer (2) is supported on the liquid-impermeable support layer (3) such that said at least one detection zone is provided above said at least one zone of the support layer having a large thickness and said at least one non-detection zone is provided above said at least one zone of the support layer having a small thickness, the zones are oriented in a direction orthogonType: ApplicationFiled: April 29, 2014Publication date: June 23, 2016Inventors: Dieter MELZNER, Denise VAN ROSSUM
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Publication number: 20140228235Abstract: The present invention relates to a microarray device for the screening or the finding of protein inhibitors, to a method for the production thereof, and to a corresponding method for screening or finding protein inhibitors. The microarray device according to the invention comprises a solid supporting element having a support material, at least one protein immobilized thereon for which inhibitors are to be screened or found, and at least one known inhibitor of the at least one protein, the inhibitor being bound to the at least one protein and comprising a detectable label.Type: ApplicationFiled: April 20, 2012Publication date: August 14, 2014Inventors: Dieter Melzner, Thomas Scheper, Thomas Schuler, Frank Stahl, Denise Van Rossum, Johanna-Gabriela Walter, Carsten Zeilinger
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Patent number: 8367231Abstract: The present invention relates to a polymer electrolyte membrane for fuel cells, comprising a polymer matrix of at least one basic polymer and one or more doping agents, wherein particles containing ionogenic groups and having a mean particle diameter in the nanometer range are embedded in the polymer matrix and the particles containing ionogenic groups are distributed homogeneously in the polymer matrix in a concentration of less than 50% relative to the weight of the polymer matrix, as well as to the production and use of same, especially in high-temperature fuel cells.Type: GrantFiled: September 8, 2009Date of Patent: February 5, 2013Assignees: Elcomax Membranes GmbH, Rhein Chemie Rheinau GmbH, Lanxess Deutschland GmbHInventors: Annette Reiche, Dieter Melzner, Ulrich Mähr, Oliver Gronwald, Werner Obrecht, Thomas Früh, Torsten Ziser
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Patent number: 8101315Abstract: The invention relates to hybrid membranes that are composed of an organic polymer and an inorganic polymer, a method for producing hybrid membranes, and the use of said hybrid membranes in polymer electrolyte membrane fuel cells. The inventive hybrid membranes comprise at least one alkaline organic polymer and at least one inorganic polymer. Said polymers are blended together at a molecular level. The inorganic polymer is formed from at least one precursor monomer when the membrane is produced. The disclosed membranes are characterized in that the same are provided with high absorptivity for doping agents, have a high degree of mechanical and thermal stability in both an undoped and doped state, and feature permanently high proton conductivity.Type: GrantFiled: September 8, 2008Date of Patent: January 24, 2012Assignee: Elcomax Membranes GmbHInventors: Oliver Gronwald, Dieter Melzner, Ulrich Mahr, Annette Reiche
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Publication number: 20110091788Abstract: The invention relates to a gas diffusion electrode for polymer electrolyte fuel cells having a working temperature of up to 250° C., comprising a plurality of gas-permeable electroconductive layers having at least one gas diffusion layer and one catalyst layer. The catalyst layer contains particles of an average particle diameter in the nanometer range, said particles containing ionogenic groups. The invention also relates to the production of said gas diffusion electrode and to the use of same in high-temperature polymer electrolyte membrane fuel cells.Type: ApplicationFiled: December 14, 2010Publication date: April 21, 2011Applicants: Elcomax GmbH, Lanxess Deutschland GmbH, Rhein Chemie Rheinau GmbHInventors: Torsten Ziser, Thomas Früh, Domnik Bayer, Werner Obrecht, Dieter Melzner, Annette Reiche, Oliver Gronwald
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Publication number: 20110082222Abstract: The invention relates to the use of a material imparting proton conductivity in the production of fuel cells, said material consisting of monomer units and having an irregular shape.Type: ApplicationFiled: December 14, 2010Publication date: April 7, 2011Applicants: Elcomax GmbH, Rhein Chemie Rheinau GmbHInventors: Torsten Ziser, Thomas Früh, Domnik Bayer, Dieter Melzner, Annette Reiche
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Patent number: 7682722Abstract: A membrane-electrode assembly and polymer electrolyte fuel cells and methods of production thereof, in which a polymer membrane, containing at least one basic polymer membrane, is sandwiched between two flat gas diffusion electrodes each of which is loaded with a dopant, whereby after reaching a mass transport equilibrium for the exchange of the dopant between the gas diffusion electrodes and the polymer membrane, the polymer membrane has a conductivity of at least 0.1 S/m at a temperature of no less than 25° C.Type: GrantFiled: July 19, 2005Date of Patent: March 23, 2010Assignee: elcomax membranes GmbHInventors: Dieter Melzner, Annette Reiche, Ulrich Maehr, Suzana Kiel
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Patent number: 7682723Abstract: A membrane for fuel cells, which is characterized by a homogeneous absorption and good retention of doping agents, and which guarantees a high mechanical stability at high temperatures when doped. Such membranes consist of at least one polymer, whose nitrogen atoms are chemically bonded to a central atom of a derivative of a polybasic inorganic oxo acid. The membranes are produced from polymer solutions that are devoid of water and oxo acid derivatives, by heating the solution that has been introduced into a membrane mold until a self-supporting membrane has been formed and then by thermally regulating the latter. Inventive fuel cells having a membrane electrode assembly (MEA) that comprises a membrane of the invention and phosphoric acid as the doping agent have, for example, an impedance of 0.5-1 ?cm2 at a measuring frequency of 1000 Hz and at an operating temperature of 160° C. and a gas flow for hydrogen of 170 mL/min and for air of 570 mL/min.Type: GrantFiled: August 4, 2006Date of Patent: March 23, 2010Assignee: Volkswagen AGInventors: Dieter Melzner, Annette Reiche, Ulrich Maehr, Suzana Kiel, Stefan Haufe
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Publication number: 20100068593Abstract: The present invention relates to a polymer electrolyte membrane for fuel cells, comprising a polymer matrix of at least one basic polymer and one or more doping agents, wherein particles containing ionogenic groups and having a mean particle diameter in the nanometer range are embedded in the polymer matrix and the particles containing ionogenic groups are distributed homogeneously in the polymer matrix in a concentration of less than 50% relative to the weight of the polymer matrix, as well as to the production and use of same, especially in high-temperature fuel cells.Type: ApplicationFiled: September 8, 2009Publication date: March 18, 2010Applicants: ELCOMAX MEMBRANES GMBH, LANXESS DEUTSCHLAND GMBH, RHEIN CHEMIE RHEINAU GMBHInventors: Annette Reiche, Dieter Melzner, Ulrich Mähr, Oliver Gronwald, Werner Obrecht, Thomas Früh, Torsten Ziser
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Patent number: 7655334Abstract: A proton-conducting electrolyte membrane is disclosed, comprising at least one base material and at least one dopant, which is the reaction product of an at least dibasic inorganic acid with an organic compound, comprising one acidic hydroxyl group, or the condensation product of said compound with a polybasic acid. The membrane may be produced by a single step method, which avoids the use of dangerous materials and environmental pollutants. Subsequent doping of the membrane, e.g., in conjunction with assembly of the membrane electrode assembly (MEA) is not excluded. The electrolyte membrane has a high and constant mechanical stability and flexibility, excellent chemical and thermal stability and a high and constant conductivity. The membrane may be used in a fuel cell in a wide temperature range from 50° C. to more than 200° C., for example, whereby the fuel cell has a high and constant power level over the entire temperature range.Type: GrantFiled: November 7, 2002Date of Patent: February 2, 2010Assignee: Volkswagen AGInventors: Dieter Melzner, Suzana Kiel, Ulrich Mahr, Annette Reiche
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Patent number: 7615306Abstract: A membrane electrode assembly (MEA) for a fuel cell, which has a planar polymer membrane. This membrane, in a tangentially inner area, is coated on both sides with electrode structure, and, in a tangentially outer area projecting at least on one side beyond the electrode structure coating, is connected to a sealing member. A marginal zone of the polymer membrane is embedded in the elastomer sealing member. The sealing member extends tangentially inward to a transition area that lies tangentially between the outer area and the inner area, where it overlaps the electrode structures on outer faces of the electrode structures, on both of the sides of the polymer membrane.Type: GrantFiled: November 29, 2006Date of Patent: November 10, 2009Assignee: Elcomax Membranes GmbHInventors: Stefan Haufe, Annette Reiche, Suzana Kiel, Ulrich Maehr, Dieter Melzner
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Publication number: 20090075141Abstract: The invention relates to hybrid membranes that are composed of an organic polymer and an inorganic polymer, a method for producing hybrid membranes, and the use of said hybrid membranes in polymer electrolyte membrane fuel cells. The inventive hybrid membranes comprise at least one alkaline organic polymer and at least one inorganic polymer. Said polymers are blended together at a molecular level. The inorganic polymer is formed from at least one precursor monomer when the membrane is produced. The disclosed membranes are characterized in that the same are provided with high absorptivity for doping agents, have a high degree of mechanical and thermal stability in both an undoped and doped state, and feature permanently high proton conductivity.Type: ApplicationFiled: September 8, 2008Publication date: March 19, 2009Applicant: ELCOMAX MEMBRANES GMBHInventors: Oliver GRONWALD, Dieter MELZNER, Ulrich MAHR, Annette REICHE