Patents by Inventor Dieter Petzinna
Dieter Petzinna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5502057Abstract: For the treatment of lipoproteinaemia and arteriosclerosis, the new disubstituted pyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heteroaryl,R.sup.2 is cycloalkyl or optionally substituted alkyl,R.sup.3 is hydrogen, cycloalkyl, or optionally substituted alkyl, aryl or heteroaryl,x is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--,A is ##STR2## R.sup.6 is hydrogen or alkyl, and R.sup.7 is hydrogen, alkyl, aralkyl or a cation.Type: GrantFiled: July 14, 1993Date of Patent: March 26, 1996Assignee: Bayer AktiengesellschaftInventors: Rolf Angerbauer, Peter Fey, Walter Hu/ bsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gu/ nter Thomas
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Patent number: 5470982Abstract: For the treatment of lipoproteinaemia and arteriosclerosis, the new disubstituted pyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heteroaryl,R.sup.2 is cycloalkyl or optionally substituted alkyl,R.sup.3 is hydrogen, cycloalkyl, or optionally substituted alkyl, aryl or heteroaryl,X is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--,A is ##STR2## R.sup.6 is hydrogen or alkyl, and R.sup.7 is hydrogen, alkyl, aralkyl or a cation.Type: GrantFiled: September 24, 1992Date of Patent: November 28, 1995Assignee: Bayer AktiengesellschaftInventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
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Patent number: 5401746Abstract: Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula ##STR1## in which A, B, D and E can have varied meanings,X is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--, andR is ##STR2## wherein R.sup.21 --denotes hydrogen or alkyl andR.sup.22 --denotes hydrogen,denotes alkyl, aryl or aralkyl, ordenotes a cation,and their oxidation products.Type: GrantFiled: July 20, 1992Date of Patent: March 28, 1995Assignee: Bayer AktiengesellschaftInventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
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Patent number: 5183897Abstract: Intermediate imino-substituted pyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl,R.sup.2 is optionally substituted aryl or alkyl, OH, alkoxy, aralkoxy, or optionally substituted aryloxy,R.sup.3 is isopropyl,R.sup.4 is isopropylX is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--,R is ##STR2## R.sup.6 is H or alkyl, and R.sup.7 is H, alkyl, phenylalkyl, aryl or a cation, and their salts.Type: GrantFiled: April 18, 1991Date of Patent: February 2, 1993Assignee: Bayer AktiengesellschaftInventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt
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Patent number: 5177080Abstract: Substituted pyridyl-dihydroxy-heptenoic acid of the formula ##STR1## and its salts, if desired in an isomeric form, have a superior inhibitory action on HMG-CoA reductase and thus bring about a surprisingly good lowering of the cholesterol content in the blood.Type: GrantFiled: November 26, 1991Date of Patent: January 5, 1993Assignee: Bayer AktiengesellschaftInventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
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Patent number: 5173495Abstract: For the treatment of lipoproteinaemia and arteriosclerosis, the polysubstituted pridines of the formula ##STR1## in which R.sup.1 is optionally substituted furyl or thienyl,R.sup.2 is cycloalkyl or optionally substituted alkyl,R.sup.3 is hydrogen, cycloalkyl, or optionally substituted alkyl, aryl or heteroaryl,X is --CH.dbd.CH--,A is ##STR2## R.sup.6 is hydrogen or alkyl, and R.sup.7 is hydrogen, alkyl, aralkyl or a cation.Type: GrantFiled: August 8, 1990Date of Patent: December 22, 1992Assignee: Bayer AktiengesellschaftInventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
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Patent number: 5169857Abstract: Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula ##STR1## in which A, B, D and E can have varied meanings,X is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--, andR is ##STR2## wherein R.sup.21 denotes hydrogen or alkyl andR.sup.22denotes hydrogen,deontes alkyl, aryl or aralkyl, ordenotes a cation,and their oxidation products.Type: GrantFiled: December 13, 1990Date of Patent: December 8, 1992Assignee: Bayer AktiengesellschaftInventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
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Patent number: 5164506Abstract: For inhibiting HMG-CoA reductase and cholesterol synthesis, the novel 2-pyridones and pyrid-2-thiones of the formula ##STR1## in which A is optionally substituted aryl or heterocyclic,B is optionally substituted alkyl, cycloalkyl or aryl,D and E independently are optionally substituted aryl or heterocyclic, H, nitro, cyano, optionally substituted alkyl, alkenyl or imino, amino, alkoxy or acyl, or forms a ring with B,G is O or S,X is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, andR represents a group of the formula ##STR2## and salts thereof.Type: GrantFiled: April 19, 1991Date of Patent: November 17, 1992Assignee: Bayer AktiengesellschaftInventors: Peter Fey, Rolf Angerbauer, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
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Patent number: 5145959Abstract: Substituted pyrido(2,3-d) pyrimidines of the formula: ##STR1## useful as intermediates for the preparation of MMG-CoA reductase inhibitors.Type: GrantFiled: June 19, 1991Date of Patent: September 8, 1992Assignee: Bayer AktiengesellschaftInventors: Walter Hubsch, Rolf Angerbauer, Peter Fey, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
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Patent number: 5145857Abstract: HMG-COA reductase-inhibiting compounds of the formula ##STR1## in which X represents a group of the formula --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--,R represents a group of the formula ##STR2## R.sup.1 represents optionally substituted aryl, R.sup.2 represents --CH.sub.2 OR.sup.8 or --X--R, andR.sup.5 represents straight-chain or branched alkyl having up to 10 carbon atoms, orand their pharmaceutically acceptable salts.Type: GrantFiled: August 15, 1990Date of Patent: September 8, 1992Assignee: Bayer AktiengesellschaftInventors: Peter Fey, Rolf Angerbauer, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt
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Patent number: 5075311Abstract: New substituted pyrido(2,3-d)pyrimidines of the formula ##STR1## can be prepared by reduction of corresponding pyrido(2,3-d)-pyrimidines which are substituted by a ketone radical, and subsequent hydrolysis, cyclization or hydrogenation. The new compounds can be used to inhibit HMG-CoA reductase.Type: GrantFiled: January 2, 1990Date of Patent: December 24, 1991Assignee: Bayer AktiengesellschaftInventors: Walter Hubsch, Rolf Angerbauer, Peter Fey, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
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Patent number: 5064841Abstract: HMG-CoA reductase-inhibiting imino-substituted pyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl,R.sup.2 is optionally substituted aryl or alkyl, OH, alkoxy, aralkoxy, or optionally substituted aryloxy,R.sup.3 is cycloalkyl, or optionally substituted aaryl or alkyl,R.sup.4 is alkyl or cycloalkyl,X is --CH.sub.2 --CH.sub.2 -- or .sub.[CH.dbd.CH--,R is ##STR2## R.sup.6 is H or alkyl, and R.sup.7 is H, alkyl, phenylalkyl, aryl or a cation, and their salts.Type: GrantFiled: July 26, 1990Date of Patent: November 12, 1991Assignee: Bayer AktiengesellschaftInventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt
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Patent number: 5034399Abstract: Inhibitors of 3-hydrooxy-3-methyl-glutarylcoenzyme A reductase which are 1,8-naphthyridines of the formula ##STR1## in which Arepresents a 3- to 7-membered heterocycle which is optionally substituted, or aryl which is optionally substituted,Brepresents cycloalkyl or alkyl which is optionally substituted, aryl which is optionally substituted,D and E are identical or different andrepresents hydrogen, halogen, mercapto, hydroxyl, alkoxy, alkyl which is optionally substituted, or a group of the formula --NR.sup.1 R.sup.2, aryl, aryloxy or arylthio having 6 to 10 carbon atoms, which is optionally substituted,Yrepresents a group of the formula ##STR2## in which Jdenotes hydrogen, hydroxyl, mercapto or halogen, or alkyl, alkoxy or alkylthio which are optionally substituted, aryloxy, benzyloxy or arylthio or a group of the formula --NR.sup.1 R.sup.2,Zdenotes oxygen or sulphur,Gdenotes hydrogen, alkyl or alkenyl which is optionally substituted,Xrepresents a group of the formula --CH.sub.2 --CH.sub.2 -- or --CH.dbd.Type: GrantFiled: March 21, 1990Date of Patent: July 23, 1991Assignee: Bayer AktiengesellschaftInventors: Walter Hubsch, Rolf Angerbauer, Peter Fey, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt
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Patent number: 5032602Abstract: For inhibiting HMG-CoA reductase and cholesterol synthesis, the novel 2-pyridones and pyrid-2-thiones of the formula ##STR1## in which A is optionally substituted aryl or heterocyclic,B is optionally substituted alkyl, cycloalkyl or aryl,D and E independently are optionally substituted aryl or heterocyclic, H, nitro, cyano, optionally substituted alkyl, alkenyl or imino, amino, alkoxy or acyl, or forms a ring with B,G is O or S,X is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, andR represents a group of the formula ##STR2## and salts thereof.Type: GrantFiled: November 27, 1989Date of Patent: July 16, 1991Assignee: Bayer AktiengesellschaftInventors: Peter Fey, Rolf Angerbauer, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
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Patent number: 5032590Abstract: Substituted hydroxylamines of the formula ##STR1## in which R.sup.1 stands for an aromatic or heterocyclic radical,are especially useful in the treatment of hyperlipoproteinaemia, lipoproteinaemia and atherosclerosis.Type: GrantFiled: March 8, 1990Date of Patent: July 16, 1991Assignee: Bayer AktiengesellschaftInventors: Walter Hubsch, Rolf Angerbauer, Peter Fey, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt
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Patent number: 5026714Abstract: Novel blood sugar-lowering dihydropyridinelactones of the formula ##STR1## in which R represents halogen, C.sub.1 -C.sub.10 -alkyl, C.sub.1 -C.sub.10 -alkoxy, C.sub.1 -C.sub.10 -alkylthio, C.sub.1 -C.sub.10 -alkylsulphinyl, C.sub.1 -C.sub.10 -alkylsulphonyl, cyano, C.sub.1 -C.sub.6 - mono- or polyfluoroalkyl, C.sub.1 -C.sub.6 -mono- or polyfluoroalkoxy or nitro,R.sup.1 represents hydrogen, halogen or C.sub.1 -C.sub.10 -alkyl or C.sub.1 -C.sub.10 -alkoxy,R.sup.2 represents a C.sub.1 -C.sub.20 hydrocarbon radical which can optionally be interrupted or substituted,R.sup.3 represents hydrogen NH.sub.2, CHO, CN or a C.sub.1 -C.sub.6 hydrocarbon radical which can be interrupted in the chain, andR.sup.4 represents a C.sub.1 -C.sub.10 -alkyl or C.sub.2 -C.sub.10 -alkenyl radical which can optionally be interrupted or substituted with the proviso that R is not CF.sub.3 if R.sup.2 represents C.sub.2 H.sub.5.Type: GrantFiled: November 13, 1989Date of Patent: June 25, 1991Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Friedrich Bossert, Hilmar Bischoff, Dieter Petzinna, Walter Puls, Klaus Schlossmann
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Patent number: 5006530Abstract: Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula ##STR1## in which A, B, D and E can have varied meanings,X is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--, andR is ##STR2## wherein R.sup.21 denotes hydrogen or alkyl andR.sup.22denotes hydrogen,denotes alkyl, aryl or aralkyl, ordenotes a cation,and their oxidation products.Type: GrantFiled: January 17, 1989Date of Patent: April 9, 1991Assignee: Bayer AktiengesellschaftInventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
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Patent number: 4992462Abstract: For inhibiting 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase, the novel substituted pyrroles of the formula ##STR1## in which R.sup.1 is optionally alkyl or cycloalkyl,R.sup.2 and R.sup.3 each is optionally substituted aryl or heteroaryl,R.sup.4 is H or an organic radical,X is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--,A is ##STR2## R.sup.7 is H or alkyl, and R.sup.8 is H or an ester or cation radical.Novel intermediates therefor are also provided.Type: GrantFiled: April 7, 1988Date of Patent: February 12, 1991Assignee: Bayer AktiengesellschaftInventors: Walter Hubsch, Rolf Angerbauer, Peter Fey, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
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Patent number: 4988711Abstract: Inhibiting HMG-CoA reductase, as in treating hyperlipopproteinaemia, lipoproteinaemia and arteriosclerosis, with the new N-substituted N-amino-pyrroles of the formula ##STR1## in which R.sup.1 is an organic radical,R.sup.2 is an aryl or heteroaryl radical,R.sup.3 is a hydrogen or an organic radical,R.sup.4 and R.sup.5 each independently is hydrogen or an organic radical or, together, they complete a heterocylic ring,X is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--,A is ##STR2## R.sup.10 is hydrogen or alkyl, and R.sup.11 is hydrogen, an organic radical or a cation.Type: GrantFiled: April 12, 1989Date of Patent: January 29, 1991Assignee: Bayer AktiengesellschaftInventors: Rolf Angerbauer, Walter Hubsch, Peter Fey, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
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Patent number: 4973598Abstract: HMG-CoA reductase-inhibiting compounds of the formula ##STR1## in which R.sup.1 is an optionally substituted alkyl as cycloalkyl radical,R.sup.2 is an optionally substituted aryl or heteroaryl radical,R.sup.3 is hydrogen or an organic radical,B is O or S,X is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--,A is ##STR2## R.sup.6 is hydrogen or alkyl, and R.sup.7 is hydrogen, alkyl, aralkyl, aryl or a cation.Type: GrantFiled: February 22, 1989Date of Patent: November 27, 1990Assignee: Bayer AktiengesellschaftInventors: Peter Fey, Rolf Angerbauer, Walter Hubsch, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas