Abstract: Disclosed is an immunoassay method for detecting an analyte such as an antigen or an antibody in an isolated sample suspected to contain the analyte by incubating the sample with a plurality of binding partners, one of which carries a detectable label, wherein a label-specific binding partner is added that does not carry a label but binds to the detectable label. The method is applicable for a large variety of analytes and has proven particularly useful for analyte antibodies of the IgG and IgM class present in samples due to infections by pathogens. Also disclosed is a reagent kit useful for the method comprising at least two analyte-specific binding partners one of which carries a detectable label and a label-specific binding partner that binds to said detectable label but itself does not carry a detectable label.

Abstract: The invention concerns variants of JL7 antigens that are suitable for detecting antibodies against Trypanosoma cruzi (causing Chagas disease) in an isolated biological sample. These antigens comprise a JL7 specific amino acid sequence, said JL7 specific sequence consisting of two copies of SEQ ID NO. 2, wherein each of said two copies has an amino acid identity of at least 90% to SEQ ID NO.2 and wherein no further Trypanosoma cruzi specific amino acid sequences are present in said polypeptide. The invention also concerns a composition of polypeptides useful for the detection of antibodies against Trypanosoma cruzi that comprises the above characterized JL7 antigen along with at least one of T. cruzi polypeptides 1F8, Cruzipain, KMP-11 and PAR-2. Moreover, it relates to a method for producing JL7 antigen as well as to diagnostic methods for detecting T. cruzi antibodies using the JL7 polypeptide.

Abstract: Disclosed is an immunoassay method for detecting an analyte such as an antigen or an antibody in an isolated sample suspected to contain the analyte by incubating the sample with a plurality of binding partners, one of which carries a detectable label, wherein a label-specific binding partner is added that does not carry a label but binds to the detectable label. The method is applicable for a large variety of analytes and has proven particularly useful for analyte antibodies of the IgG and IgM class present in samples due to infections by pathogens. Also disclosed is a reagent kit useful for the method comprising at least two analyte-specific binding partners one of which carries a detectable label and a label-specific binding partner that binds to said detectable label but itself does not carry a detectable label.

Abstract: A test management system is presented. The system comprises an analyzer to perform tests a sample according to a first set of instructions, a manager module connected to the analyzer, and a first order interface connected to the manager module. The manager module directs activity of the analyzer according to a second set of instructions. The first order interface receives an order for a first analytical test and a second analytical test and transmits the order to the manager module. If the order is for the first analytical test, the test manager module forwards the order directly to the analyzer and the sample is analyzed by the analyzer according to the first set of instructions. If the order is for the second analytical test, the manager module handles the order according to the second set of instructions and generates and transmits secondary test requests to the analyzer.

Abstract: The present invention concerns a composition of polypeptides suitable for detecting antibodies against Trypanosoma cruzi (T. cruzi) in an isolated biological sample consisting of three polypeptides 1F8, JL7 and Cruzipain. A method of producing a soluble and immunoreactive composition of polypeptides suitable for detecting antibodies against T. cruzi using said composition of polypeptides is also part of the invention. Moreover, the invention concerns a method for detecting antibodies specific for T. cruzi in an isolated sample wherein a composition of said T. cruzi polypeptides is used as well as a reagent kit comprising said composition of T. cruzi polypeptides.

Abstract: The present invention concerns a composition of polypeptides suitable for detecting antibodies against Trypanosoma cruzi (T. cruzi) in an isolated biological sample consisting of three polypeptides 1F8, JL7 and Cruzipain. A method of producing a soluble and immunoreactive composition of polypeptides suitable for detecting antibodies against T. cruzi using said composition of polypeptides is also part of the invention. Moreover, the invention concerns a method for detecting antibodies specific for T. cruzi in an isolated sample wherein a composition of said T. cruzi polypeptides is used as well as a reagent kit comprising said composition of T. cruzi polypeptides.

Abstract: The invention concerns variants of JL7 antigens that are suitable for detecting antibodies against Trypanosoma cruzi (causing Chagas disease) in an isolated biological sample. These antigens comprise a JL7 specific amino acid sequence, said JL7 specific sequence consisting of two copies of SEQ ID NO. 2, wherein each of said two copies has an amino acid identity of at least 90% to SEQ ID NO.2 and wherein no further Trypanosoma cruzi specific amino acid sequences are present in said polypeptide. The invention also concerns a composition of polypeptides useful for the detection of antibodies against Trypanosoma cruzi that comprises the above characterized JL7 antigen along with at least one of T. cruzi polypeptides 1F8, Cruzipain, KMP-11 and PAR-2. Moreover, it relates to a method for producing JL7 antigen as well as to diagnostic methods for detecting T. cruzi antibodies using the JL7 polypeptide.

Abstract: A device arrangement may include an inner casing. The inner casing may include an inner casing base and an inner casing cover defining a cavity therebetween. The cavity may receive an electronic device. The inner casing base may have a first viewing window. A window pane may be composed of a transparent material and be attached to at least one of the electronic device and the inner casing. The window pane may at least partially seal the first viewing window. An outer casing may at least partially encase the inner casing. The inner casing may be mounted on the outer casing via a suspension/damping device.

Abstract: A test management system is presented. The system comprises an analyzer to perform tests a sample according to a first set of instructions, a manager module connected to the analyzer, and a first order interface connected to the manager module. The manager module directs activity of the analyzer according to a second set of instructions. The first order interface receives an order for a first analytical test and a second analytical test and transmits the order to the manager module. If the order is for the first analytical test, the test manager module forwards the order directly to the analyzer and the sample is analyzed by the analyzer according to the first set of instructions. If the order is for the second analytical test, the manager module handles the order according to the second set of instructions and generates and transmits secondary test requests to the analyzer.

Abstract: A device arrangement may include a casing surrounding a casing interior. The casing may include a viewing window which is sealed by a transparent window pane. An electronic device may be disposed in the casing interior and have a display. The display may be secured in a fixed position on the window pane. A suspension/damping device may support at least one of the window pane and the electronic device on the casing.

Abstract: A device arrangement for receiving an electronic device may include a casing enclosing at least partially a casing interior. A resilient partition wall may be disposed in the casing and divide the casing interior into a first sub-chamber and a second sub-chamber fluidically separated from the first sub-chamber. The first sub-chamber may be configured to receive the electronic device. The first sub-chamber may include a first gas at a pre-determined gas pressure and the second sub-chamber may include a second gas having a second gas pressure. A pressurizing device may be disposed in the casing interior and be configured to increase the pre-determined gas pressure of the first sub-chamber by a pre-determined amount in relation to the second gas pressure in the second sub-chamber. The second sub-chamber may communicate fluidically with a surrounding environment of the casing.

Abstract: A device arrangement for receiving an electronic device may include a casing enclosing at least partially a casing interior. A resilient partition wall may be disposed in the casing and divide the casing interior into a first sub-chamber and a second sub-chamber fluidically separated from the first sub-chamber. The first sub-chamber may be configured to receive the electronic device. The first sub-chamber may include a first gas at a pre-determined gas pressure and the second sub-chamber may include a second gas having a second gas pressure. A pressurising device may be disposed in the casing interior and be configured to increase the pre-determined gas pressure of the first sub-chamber by a pre-determined amount in relation to the second gas pressure in the second sub-chamber. The second sub-chamber may communicate fluidically with a surrounding environment of the casing.

Abstract: A device arrangement may include a casing surrounding a casing interior. The casing may include a viewing window which is sealed by a transparent window pane. An electronic device may be disposed in the casing interior and have a display. The display may be secured in a fixed position on the window pane. A suspension/damping device may support at least one of the window pane and the electronic device on the casing.

Abstract: A device arrangement may include an inner casing. The inner casing may include an inner casing base and an inner casing cover defining a cavity therebetween. The cavity may receive an electronic device. The inner casing base may have a first viewing window. A window pane may be composed of a transparent material and be attached to at least one of the electronic device and the inner casing. The window pane may at least partially seal the first viewing window. An outer casing may at least partially encase the inner casing. The inner casing may be mounted on the outer casing via a suspension/damping device.

Abstract: The tooth implant includes a conical screw section with a multiple thread, which broadens progressively from the rounded apical end thereof, is adjoined by a multiple micro-thread with a lower pitch. Such an implant has improved primary stability and avoids the injury of anatomical structures and with the micro-thread thereof avoids too high a compression and necrosis. In one example, an abutment with a post is fixed to the implant, which post includes a groove to which various structures can be clipped.