Abstract: The present invention describes 2-methyl-quinazoline compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions. The 2-methyl substituted quinazoline compounds of general formula (I) effectively and selectively inhibit the Ras-Sos interaction without significantly targeting the EGFR receptor. They are therefore useful for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, such as cancer as a sole agent or in combination with other active ingredients.

Abstract: Method and apparatus for testing the correspondence of the line of sight of optical instruments with the target line of weapons. A predetermined measuring field and a photoelectric line-type sensor are used. The nominal positions of the lines of sight and of the target lines relative to each other are stored as coordinates in a long-time memory. Simultaneously a nominal reference point as the origin of the coordinate system stored in the long-time memory is determined.

Abstract: A method for separately evaluating the contents of an image in two coordinate directions of motion by splitting and then reflecting the received image so that the images may be separately analyzed.An apparatus for performing the method which comprises a beam splitter, a reflector and a correlating grid.A method of measuring distance by using the apparatus of the invention is also disclosed.