Abstract: A device method and computer program product are disclosed for trend prediction of the course of a time-dependent series of data points of a component or system, particularly for an aircraft or spacecraft, including: providing an optimised decision tree, the input node of which is provided for inputting an input vector, the nodes of which contain the data points of a respective input vector and the leaves of which each contain an extrapolation function; iteratively calculating future data points by a respective time-dependent series of data points being inputted into the decision tree as an input vector and the decision tree calculating therefrom a data point subsequent to the last data point of the input vector in an automated manner, the calculated subsequent data point being added to the time-dependent series of data points in order to be used as a new input vector for the next iteration step.

Abstract: A computer-implemented method, a computer program product and a device for the condition monitoring of a component or system, such as for an aircraft or spacecraft. The method includes: providing an optimized decision tree, the nodes of which contain attributes of an input vector, the leaves of which each contain a classification function and the connections of which between the nodes are weighted; providing an input vector derived from a data signal; implementing a condition monitoring in which the condition of the component or system is determined using the weighted decision tree and on the basis of the input vector. In addition to an item of information concerning which of the classification functions of the decision tree best corresponds to the input vector, an additional item of information concerning the probability with which the other classes of the decision tree correspond to the examined input vector is calculated and output.

Abstract: A computer-implemented method, a computer program product and a device for the condition monitoring of a component or system, such as for an aircraft or spacecraft. The method includes: providing an optimised decision tree, the nodes of which contain attributes of an input vector, the leaves of which each contain a classification function and the connections of which between the nodes are weighted; providing an input vector derived from a data signal; implementing a condition monitoring in which the condition of the component or system is determined using the weighted decision tree and on the basis of the input vector. In addition to an item of information concerning which of the classification functions of the decision tree best corresponds to the input vector, an additional item of information concerning the probability with which the other classes of the decision tree correspond to the examined input vector is calculated and output.

Abstract: A device method and computer program product are disclosed for trend prediction of the course of a time-dependent series of data points of a component or system, particularly for an aircraft or spacecraft, including: providing an optimised decision tree, the input node of which is provided for inputting an input vector, the nodes of which contain the data points of a respective input vector and the leaves of which each contain an extrapolation function; iteratively calculating future data points by a respective time-dependent series of data points being inputted into the decision tree as an input vector and the decision tree calculating therefrom a data point subsequent to the last data point of the input vector in an automated manner, the calculated subsequent data point being added to the time-dependent series of data points in order to be used as a new input vector for the next iteration step.

Abstract: The invention relates to phenyl-[4-(3-phenyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amine derivatives and to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumor.

Abstract: Leukocyte Function-Associated Antigen One (LFA-1) is a cell adhesion molecule selectively expressed on leukocytes, and plays a major role in the activation and trafficking of T lymphocytes in the tissue at sites of inflammation. In the last decade a large body of preclinical data has accumulated to establish the importance of LFA-1 as a biological target, 10 particularly in chronic, T-cell driven inflammatory conditions. The present invention provides pharmaceutically active 1,4-diazepan-2-ones of formula I useful for the treatment of conditions related to LFA-1 activity.

Abstract: The invention relates to phenyl-[4-(3-phenyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amine derivatives and to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.

Abstract: Monoclonal murine internal image anti-idiotypic antibodies (Ab2) to monoclonal antibodies BR55-2 (Ab1), process for the production thereof and use for prophylactic and/or therapeutic immunization against HIV-infections, against cancer of epithelial origin and against small cell lung cancer.

Abstract: The present invention relates to the new use of 2,4-diamino-3-hydroxycarboxylic acids of formula (I), in which A and B independently represent a bond or an unsubstituted or substituted amino acyl moiety; R1 represents hydrogen; an amino protecting group; or a group of formula R5Y— wherein R5 represents hydrogen or an unsubstituted or substituted alkyl, alkenyl, alkinyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl group; and Y represents —CO—; —NH—CO—; —NH—CS—; —SO2—; —O—CO—; or —O—CS—; R2 represents the side chain of a natural amino acid; an alkyl, arylalkyl, heteroarylalkyl or cycloalkylalkyl group; or trimethylsilylmethyl, 2-thienylmethyl or styrylmethyl; R3 represents halogen, alkyl, alkoxy or hydroxyalkoxy; and R4 represents 2(R)-hydroxyindan-1(S)-yl; (S)-2-hydroxy-1-phenylethyl; or 2-hydroxy-benzyl unsubstituted or substituted in 4-position by methoxy; in the manufacture of a pharmaceutical composition for the treatment of a proliferative disease, e.g.

Abstract: Monoclonal murine internal image anti-idiotypic antibodies (Ab2) to monoclonal antibodies BR55-2 (Ab1), process for the production thereof and use for prophylactic and/or therapeutic immunization against HIV-infections, against cancer of epithelial origin and against small cell lung cancer.

Abstract: The invention relates to compounds of formula I ##STR1## wherein the substituents have various significances. They can be prepared by conventional methods, e.g. coupling, substitution, deprotection or protection reactions.They possess interesting pharmacological properties and are thus indicated for use in the treatment of retroviral infections, particularly as HIV proteinase inhibitors.

Abstract: Monoclonal antibody BR55-2 and fragments thereof having the specificity of monoclonal antibody BR55-2, and variants thereof, are useful in the treatment of small cell lung carcinoma.

Abstract: 2',3'-dideoxynucleoside pyrimidine compounds and 2-thiothymidine carbocyclic derivatives with antiviral activity are disclosed. These compounds are expected to exhibit antiviral activity recognized for 2',3'-dideoxynucleoside compounds and analogs thereof.

Abstract: The invention relates to new nucleating agents for the preparation of directly gassed thermoplastic foams. The new agents comprise a combination of citric acid, the salts or esters thereof and carbonate or bicarbonate and talc.

Abstract: A process for treating AIDS, which comprises administering to a patient in need therefor a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula ##STR1## wherein: R.sub.1 is an adenine, cytosine, guanine, thymidine, uracil, 5-substituted uracil, 5-substituted cytosine derivative, 2-fluoroadenine, 2.6-diaminopurine, 2-aminopurine, 6-thioguanine, or 7-deazaadenine group;R.sub.2 is H, or a OH group;R.sub.3 is a OH, O-acyl, O-palmitoyl group or phosphates (as free acid, or its alkali, ammonium or alkyl ammonium salts), or any other precursor group for the hydroxyl group;or a physiologically acceptable salt thereof.

Abstract: A method for treating AIDS, which comprises administering to a patient in need therefor a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula ##STR1## wherein R.sub.1 is an adenine, cytosine, guanine, thymidine, uracil, 5-substituted uracil, 5-substituted cytosine derivative, 2-fluoroadenine, 2.6-diaminopurine, 2-aminopurine, 6-thioguanine, or 7-deazaadenine group;R.sub.2 is H, or a OH group;R.sub.3 is a OH, O-acyl, O-palmitoyl group, or phosphates (as free acid, or its alkali, ammonium or alkyl ammonium salts), or any other precursor group for the hydroxyl group;or a physiologically acceptable salt thereof.

Abstract: Method of determining the quality characteristic of running yarns, in which the number of yarn imperfections is ascertained with the aid of fluff counters, wherein the thread passes through at least three fluff sensors of the same type arranged one after another, whose counting pulses, which are emitted upon passage, by a yarn section of the freely selectable length L, are converted into a length-related average R, highly deviant individual measurement results being regarded as outlier values and not being included in the averaging.

Abstract: An axially elongated rock drill includes an axially extending shank and a drill head on one end of the shank. The drill head has a drill face extending transversely of the axial direction of the rock drill. A hard metal cutting plate and hard metal cutting pins are set in the drill face. The cutting pins reduce the wear on the cutting plate and afford better support of the drill. The cutting pins are arranged, in part, parallel to the axis of the drill, and, in part, inclined to the drill axis. The cutting plate has a cutting edge which generates a cutting plane as the drill is rotated with the ends of the cutting pins projecting from the drill face being located in the generated cutting plane.

Abstract: The invention relates to new blowing and nucleating agents for the processing of plastics, which are based on mono- and diesters of citric acid.

Abstract: A drill is secured in percussion drilling machines and in tool holders of hammer drills by locking elements. The locking elements fit into axially extending grooves formed in the axially extending circumferential surface of the shank of the drill. Webs located intermediate the ends of the grooves divide the grooves into axially extending groove sections with the locking elements fitting into the groove sections. The outer surfaces of the webs are located in the circumferential surface of the shank and serve to support the jaws of the tool holder in the correct position.