Patents by Inventor Dietmar Rabussay

Dietmar Rabussay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210308451
    Abstract: This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.
    Type: Application
    Filed: April 20, 2021
    Publication date: October 7, 2021
    Inventors: Paul Goldfarb, Dietmar Rabussay
  • Patent number: 11007365
    Abstract: This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: May 18, 2021
    Assignee: ONCOSEC MEDICAL INCORPORATED
    Inventors: Paul Goldfarb, Dietmar Rabussay
  • Publication number: 20200289818
    Abstract: This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.
    Type: Application
    Filed: February 28, 2020
    Publication date: September 17, 2020
    Inventors: Rune KJEKEN, Stephen Vincent KEMMERRER, Feng LIN, Dietmar RABUSSAY, Thomas Joseph KARDOS
  • Patent number: 10610684
    Abstract: This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: April 7, 2020
    Assignee: Genetronics, Inc.
    Inventors: Rune Kjeken, Stephen Vincent Kemmerrer, Feng Lin, Dietmar Rabussay, Thomas Joseph Kardos
  • Publication number: 20170216585
    Abstract: This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.
    Type: Application
    Filed: April 14, 2017
    Publication date: August 3, 2017
    Inventors: Paul Goldfarb, Dietmar Rabussay
  • Patent number: 9037230
    Abstract: This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: May 19, 2015
    Assignee: OncoSec Medical Incorporated
    Inventors: Paul Goldfarb, Dietmar Rabussay
  • Publication number: 20120143120
    Abstract: This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.
    Type: Application
    Filed: October 21, 2011
    Publication date: June 7, 2012
    Inventors: Paul GOLDFARB, Dietmar RABUSSAY
  • Publication number: 20110009807
    Abstract: This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.
    Type: Application
    Filed: July 14, 2010
    Publication date: January 13, 2011
    Applicant: GENETRONICS, INC.
    Inventors: Rune KJEKEN, Stephen Vincent KEMMERRER, Feng LIN, Dietmar RABUSSAY, Thomas Joseph KARDOS
  • Publication number: 20080058706
    Abstract: The invention comprises a modular electroporation device for use in clinical settings. The device includes components which may be varied or adapted for application of electroporation-based delivery of therapeutic agents to cells of a subject in a variety of electroporation formats such as intratissue electroporation or transsurface electroporation. The device components include a hand-manipulable handle with activation switch and a disposable head comprising electrodes, injection port, electrode directional and depth guide, and a slideably engaged electrode safety shield.
    Type: Application
    Filed: April 10, 2007
    Publication date: March 6, 2008
    Applicant: Genetronics, Inc.
    Inventors: Lei Zhang, Andre Gamelin, Dietmar Rabussay
  • Publication number: 20070239099
    Abstract: This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.
    Type: Application
    Filed: March 2, 2007
    Publication date: October 11, 2007
    Inventors: Paul Goldfarb, Dietmar Rabussay
  • Publication number: 20060084938
    Abstract: In vivo methods are provided for using an electric field to delivery therapeutic or immunizing treatment to a subject by applying non-invasive, user-friendly electrodes to the surface of the skin. Thus, therapeutic or immunizing agents can be delivered into cells of skin for local and systemic treatments or for immunization with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Application
    Filed: November 30, 2005
    Publication date: April 20, 2006
    Applicant: Genetronics, Inc.
    Inventors: Lei Zhang, Dietmar Rabussay
  • Publication number: 20060036210
    Abstract: The invention comprises a modular electroporation device for use in clinical settings. The device includes components which may be varied or adapted for application of electroporation-based delivery of therapeutic agents to cells of a subject in a variety of electroporation formats such as intratissue electroporation or transsurface electroporation.
    Type: Application
    Filed: June 30, 2005
    Publication date: February 16, 2006
    Inventors: Lei Zhang, Andre Gamelin, Dietmar Rabussay
  • Publication number: 20050054594
    Abstract: Methods are provided for enhancing an immune response induced by administration of a DNA vaccine. In the invention methods a DNA vaccine encoding an antigen and non-chemically associated adjuvant particles are injected into muscle, dermal or mucosal tissue of a subject at substantially the same time and the tissue is subjected to a pulsed electric field of sufficient strength to result in the DNA vaccine entering cells of the target tissue. The immune response to the antigen is enhanced as compared to when the DNA vaccine is administered alone or in combination with either of the electric pulses or the adjuvant particles without the other.
    Type: Application
    Filed: December 16, 2002
    Publication date: March 10, 2005
    Inventors: Lei Zhang, Georg Widera, Dietmar Rabussay
  • Patent number: 6746441
    Abstract: A method and apparatus for introducing a preselected molecule into a living cell by contacting the cell with the preselected molecule and applying a multiple series of electrical pulses to the cell. The method can be utilized ex vivo. The multiple electrical pulses generate rotating electric fields which introduce transient pores in the living cell without killing the cell. The rotating electric fields are provided in a flow through chamber apparatus having more than two electrodes. A three-step pulse process, e.g. collection, electroporation, electrophoresis, is used to introduce the preselected molecule into the cell. A mechanical means of repositioning cells between successive pulses is also provided. The apparatus can also provide a means to pulse cells at different temperatures and then after pulsing, let the cells recover for a specified residence time at another temperature.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: June 8, 2004
    Assignee: Genetronics, Inc.
    Inventors: Gunter A. Hofmann, Dietmar Rabussay
  • Publication number: 20020042635
    Abstract: The present invention is based on the development of a non-invasive method and apparatus for delivery of drugs into the penile erectile tissue to induce or enhance penile erection, which affords an alternative treatment for patients afflicted with erectile dysfunction (ED). Sufficient electric pulses temporarily create new pathways in the penile skin thereby driving a composition, such as a vasoactive or androgenic medication, into the corporal cavernosum.
    Type: Application
    Filed: July 24, 2001
    Publication date: April 11, 2002
    Applicant: Genetronics, Inc.
    Inventors: Lei Zhang, Gunter A. Hofmann, Dietmar Rabussay
  • Patent number: 6266560
    Abstract: A non-invasive method is provided for treating erectile dysfunction using electroporation enhanced with delivery of a vasoactive or androgenic composition applied to the penis which affords an alternative treatment for patients afflicted with erectile dysfunction (ED). Sufficient electric pulses temporarily create new pathways in the penile skin thereby driving a composition, such as a vasoactive or androgenic medication, into the corporal cavernosum.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: July 24, 2001
    Assignee: Genetronics, Inc.
    Inventors: Lei Zhang, Gunter A. Hofmann, Dietmar Rabussay
  • Patent number: 6192270
    Abstract: An electrode assembly for an apparatus for and a method of trans-surface molecular delivery, including a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface, a first electrode disposed on at least a portion of the distal surface and extending through at least a portion of the plurality of through holes and onto at least a portion of the proximal surface, a second electrode disposed on at least a portion of the proximal surface and in closely spaced relation with the first electrode for engaging a tissue surface through which to apply an electric field, and an insulating barrier that is disposed on at least a portion of the proximal surface of the carrier between the first electrode and the second electrode.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: February 20, 2001
    Assignee: Genetronics, Inc.
    Inventors: Gunter A. Hofmann, Dietmar Rabussay, Arnt Tonnessen
  • Patent number: 6027488
    Abstract: A method and apparatus for introducing a preselected molecule into a living cell by contacting the cell with the preselected molecule and applying a multiple series of electrical pulses to the cell. The method can be utilized ex vivo. The multiple electrical pulses generate rotating electric fields which introduce transient pores in the living cell without killing the cell. The rotating electric fields are provided in a flow through chamber apparatus having more than two electrodes. A three-step pulse process, e.g. collection, electroporation, electrophoresis, is used to introduce the preselected molecule into the cell. A mechanical means of repositioning cells between successive pulses is also provided. The apparatus can also provide a means to pulse cells at different temperatures and then after pulsing, let the cells recover for a specified residence time at another temperature.
    Type: Grant
    Filed: June 3, 1998
    Date of Patent: February 22, 2000
    Assignee: Genetronics, Inc.
    Inventors: Gunter A. Hofmann, Dietmar Rabussay