Abstract: 5-hydroxymethylfurfural of the formula II is prepared via a 5-acyloxymethylfurfural as an intermediate.

Abstract: An apparatus for influencing an automatic transmission has a man-machine-interface, which is connected to a transmission controller for selecting a transmission ratio of the automatic transmission connected to an internal combustion engine, and a monitoring device for monitoring at least one operating parameter that is relevant to the wear of the internal combustion engine, wherein a threshold value of the operating parameter and a desired rotation speed range of the internal combustion engine that depends on the threshold value can be selected via the man-machine-interface, and wherein the transmission controller selects a transmission ratio on the basis of the monitoring device, by which an actual rotation speed of the internal combustion engine is adjusted within the desired rotation speed range. A method for influencing an automatic transmission is also described.

Abstract: The invention relates to a method for determining the isoform composition of erythropoietin, comprising the following steps: a) isoelectrical focusing of a sample comprising erythropoietin in a gel over a pH range having a lower limit of 2.5 to 3.5 and an upper limit of 5 to 8, wherein the sample comprising erythropoietin originates from a culture supernatant of erythropoietin producing eukaryotic cells; b) transferring of the proteins comprised and separated in the gel to a membrane; c) verifying the erythropoietin bound to the membrane by specific antibodies; and to a method for in-process control of culture supernatants of erythropoietin producing eukaryotic cells during the fermentative production process.

Abstract: The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.

Abstract: The present invention relates to a process for the fermentative continuous production of erythropoietin, where eukaryotic erythropoietin-producing cells are cultured in a perfusion reactor while retaining the cells, the glucose concentration in the culture supernatant being adjusted via the perfusion rate and the cell number via the cell retention rate and/or the outward transferal of defined amounts of cell-containing culture medium from the bioreactor within preset zones.

Abstract: The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.

Abstract: The present invention relates to a method for preparing erythropoietin, wherein culture supernatant of erythropoietin-producing eukaryotic cells containing erythropoietin are subjected to the following steps: a) Removing the cell components; and b) treating the product from a) to the following chromatography steps in the sequence indicated i) reversed phase chromatography; ii) anion exchange chromatography; iii) hydroxyapatite chromatography.

Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.

Abstract: 5-hydroxymethylfurfural of the formula II is prepared via a 5-acyloxymethylfurfural as an intermediate.

Abstract: The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.

Abstract: The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.

Abstract: The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors

Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.

Abstract: The present invention relates to a process for the preparation of compounds of the general formula (I) by catalytic enantioselective hydrogenation of the corresponding ketones. There are used inter alia ruthenium catalysts with chiral diamines and chiral biphosphines as ligands.

Abstract: A novel route is described for the synthesis of N-methyl-3-hydroxy-3-(2-thienyl)propylamine IV, which can be used as a starting compound for the preparation of duloxetine. N-methyl-3-hydroxy-3-(2-thienyl)propylamine is synthesized via novel thiophene derivatives containing carbamate groups, I and IIa, as intermediates.

Abstract: The present invention relates to the preparation of compounds of formula (I): from the corresponding hydantoins by means of an enzymatic process. The L-compound is preferably formed.

Abstract: The invention relates to the use of catalysts comprising the structures of general formulas (I), (II) or (III), for the asymmetric cleavage of anhydrides.

Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents 1

Abstract: The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.

Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents 1