Patents by Inventor Dietrich Arndts

Dietrich Arndts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anellated dihydropyridines for the treatment of chronic pain
    Publication number: 20030114480
    Abstract: The invention relates to the use of anellated dihydropyridines according to the following formula I, and the salts thereof with physiologically acceptable acids, for the treatment of chronic pain, wherein A is benzo or thieno and Z, R1, R2, R3, R4, R5 and R6 are defined as in the specification: 1
    Type: Application
    Filed: September 11, 2002
    Publication date: June 19, 2003
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Dietrich Arndts, Walter Loesel, Wolfram Gaida, Klaus Klinder, Stefan Matthias Blech, Henning Draheim
  • Means of tumor therapy
    Publication number: 20030083313
    Abstract: A composition containing an antineoplastic alkylphospholipid, and an antineoplastic antiestrogen in a lipid vesicle; more particularly, the composition is a liposome composition which comprises (i) an antineoplastic alkylphospholipid,(ii) an antineoplastic water- or lipid-soluble antiestrogen associated in liposomal form with the antineoplastic alkylphospholipid, (iii) a nonneoplastic phospholipid, and optionally one or more of (iv) a sterol, (v) a positively or negatively charged lipid, and (vi) a PEG lipid.
    Type: Application
    Filed: June 4, 2001
    Publication date: May 1, 2003
    Inventors: Reinhard Zeisig, Iduna Fichtner, Dietrich Arndt
  • Anellated dihydropyridines for the treatment of chronic pain
    Patent number: 6476047
    Abstract: The invention relates to the use of anellated dihydropyridines according to the following formula I, and the salts thereof with physiologically acceptable acids, for the treatment of chronic pain, wherein A is benzo or thieno and Z, R1, R2, R3, R4, R5 and R6 are defined as in the specification: The inventions also relates to novel compounds of formula I and pharmaceutical compositions thereof.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: November 5, 2002
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Dietrich Arndts, Walter Loesel, Wolfram Gaida, Klaus Klinder, Stefan Matthias Blech, Henning Draheim
  • Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
    Patent number: 6465483
    Abstract: A compound of formula I wherein A denotes a benzo, indolo or thieno group; R1 denotes thienyl or the group  wherein R7, R8 and R9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of the substituents can simultaneously represent phenyl or benzyl; R2, m, R3 and R4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: October 15, 2002
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter Lösel, Otto Roos, Dietrich Arndts
  • Anellated dihydropyridines for the treatment of chronic pain
    Publication number: 20020045640
    Abstract: The invention relates to the use of anellated dihydropyridines according to the following formula I, and the salts thereof with physiologically acceptable acids, for the treatment of chronic pain, wherein A is benzo or thieno and Z, R1, R2, R3, R4, R5 and R6 are defined as in the specification: 1
    Type: Application
    Filed: July 19, 2001
    Publication date: April 18, 2002
    Inventors: Dietrich Arndts, Walter Loesel, Wolfram Gaida, Klaus Klinder, Stefan Matthias Blech, Hennig Draheim
  • Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
    Patent number: 6180645
    Abstract: A compound of formula I wherein A denotes a benzo, indolo or thieno group; R1 denotes thienyl or the group wherein R7, R8 and R9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of the substituents can simultaneously represent phenyl or benzyl; R2, m, R3 and R4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: January 30, 2001
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter Lösel, Otto Roos, Dietrich Arndts
  • Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
    Patent number: 6136819
    Abstract: Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --O--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1 -.sub.6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4 -.sub.7)cycloalkyl, (C.sub.4 -.sub.6)cycloalkyl(C.sub.1 -.sub.5)alkyl or ##STR2## wherein R is (C.sub.1 -.sub.4)alkyl, hydroxy, --N.sub.3, halogen (F, Cl, Br, I), CF.sub.3 or (C.sub.1 -.sub.4)alkoxy,u is 0, 1, 2 or 3, andm, R.sup.2, R.sup.4, R.sup.7, R.sup.8 and R.sup.9 are as defined in the specification, as well as pharmaceutical preparations containing these compounds and the pharmaceutical use thereof.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: October 24, 2000
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Otto Roos, Walter Losel, Dietrich Arndts
  • Pharmaceutically useful 3,4-dihydroisoquinoline
    Patent number: 6034094
    Abstract: The invention relates to the use of carbocyclically and heterocycally fused dihydroyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhabiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: March 7, 2000
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts, Franz Josef Kuhn, Ilse Strelle
  • Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
    Patent number: 5968948
    Abstract: Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --O--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1-6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4-7)cycloalkyl, (C.sub.4-6)cycloalkyl(C.sub.1-5)alkyl or ##STR2## wherein R is (C.sub.1-4)alkyl, hydroxy, --N.sub.3, halogen (F, Cl, Br, I), CF.sub.3 or (C.sub.1-4)alkoxy,u is 0, 1, 2 or 3, andm, R.sup.2, R.sup.4, R.sup.7, R.sup.8 and R.sup.9 are as defined in the specification, as well as pharmaceutical preparations containing these compounds and the pharmaceutical use thereof.
    Type: Grant
    Filed: May 16, 1997
    Date of Patent: October 19, 1999
    Assignee: Boerhinger Ingelheim GmbH
    Inventors: Otto Roos, Walter Losel, Dietrich Arndts
  • Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
    Patent number: 5925650
    Abstract: A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, whilst not more than 2 of the substituents can simultaneously represent phenyl or benzyl;R.sup.2, m, R.sup.3 and R.sup.4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: July 20, 1999
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts
  • Dihydro-isoquinoline compounds and their use as pharmaceuticals
    Patent number: 5861412
    Abstract: Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: June 10, 1997
    Date of Patent: January 19, 1999
    Assignee: Boehringer Ingelheim KG
    Inventors: Dietrich Arndts, Walter Losel, Otto Roos
  • Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
    Patent number: 5837712
    Abstract: A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of the substituents can simultaneously represent phenyl or benzyl;R.sup.2, m, R.sup.3 and R.sup.4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 17, 1998
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts
  • Benzoyl guanidine derivatives, the preparation thereof and their use in pharmaceutical compositions
    Patent number: 5783576
    Abstract: New compounds of general formula (I) are provided: ##STR1## which are explained in the specification can be prepared by a variety of methods. The compounds may be used in pharmaceutical compositions.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: July 21, 1998
    Assignee: Boehringer Ingelheim KG
    Inventors: Otto Roos, Georg Speck, Walter Losel, Dietrich Arndts, Wolf-Dietrich Bechtel
  • Pyridazino?4',5':3,4!pyrrolo-?2,1-a!-isoquinolines and the use thereof for preparing pharmaceutical preparations
    Patent number: 5688793
    Abstract: The invention relates to new pyridazino?4',5':3,4!-pyrrolo?2,1-a!isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with acids and complex-forming agents, wherein X is O, S or NHO and R.sub.1, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are defined as in the specification, and pharmaceutical preparations containing these compounds.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: November 18, 1997
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts
  • Anti-inflammatory method
    Patent number: 5686462
    Abstract: The invention relates to the use of carbocyclically and heterocyclically fused dihydropyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhibiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: November 11, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts, Franz Josef Kuhn, Ilse Strelle
  • 9-amino-pyridazino?4'5':3,4!pyrrolo-?2,1-a!isoquinolines and the use thereof for the production of pharmaceutical preparations
    Patent number: 5677304
    Abstract: The invention relates to the use of 9-amino-pyridazino-?4',5':3,4!pyrrolo?2,1-a!isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with acids, bases and complexing agents for preparing agents for treating chronic inflammatory processes, ulcerative colitis and Crohn's disease, and for producing agents having an antiproliferative activity. The definitions of substituents R.sub.1 to R.sub.9 are given in the specification. The invention also relates to new compounds of general formula I which are also defined in the specification and their use as cerebroprotective agents.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: October 14, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Dietrich Arndts, Walter Losel, Otto Roos
  • Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparations
    Patent number: 5674878
    Abstract: Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 7, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Dietrich Arndts, Walter Losel, Otto Roos
  • Cerebroprojection method
    Patent number: 5665729
    Abstract: The invention relates to the use of carbocyclically and heterocyclically fused dihydropyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhibiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: September 9, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts, Franz Josef Kuhn, Ilse Strelle
  • Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations
    Patent number: 5661157
    Abstract: Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --0--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1-6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4-7)cycloalkyl, (C.sub.4-6)cycloalkyl(C.sub.1-5)alkyl or ##STR2## wherein R is (C.sub.1-4)alkyl, hydroxy, --N.sub.3, halogen (F, Cl, Br, I), CF.sub.3 or (C.sub.1-4)alkoxy,u is 0, 1, 2 or 3, andm, R.sup.2, R.sup.4, R.sup.7, R.sup.8 and R.sup.9 are as defined in the specification, as well as pharmaceutical preparations containing these compounds and the pharmaceutical use thereof.
    Type: Grant
    Filed: December 21, 1994
    Date of Patent: August 26, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Otto Roos, Walter Losel, Dietrich Arndts
  • Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparation
    Patent number: 5643919
    Abstract: Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 1, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Dietrich Arndts, Walter Losel, Otto Roos