Abstract: The present invention relates to an immunogenic composition for Proteobacteria protection and reduced transmission. We have identified Proteobacteria serovar variant combinations that generate an immune response capable of robustly driving bacterial enteropathogens into an evolutionary dead end and reducing the transmission of the bacterium. These inactivated immunogenic positions and typically oral vaccines are easy to apply, cheap to produce, and can be stored long-term without cold-chain requirements making them ideal for application in livestock, or in resource-poor areas. They are believed to be the only immunogenic compositions and vaccine formulations capable of breaking the chain of transmission for these types of pathogen.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections. In particular, the present invention relates to a Toll-like receptor (TLR) agonist for use in a method for the treatment of a bacterial infection in a subject in need thereof wherein the TLR agonist is administered to the subject in combination with at least one antibiotic.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections. In particular, the present invention relates to a Toll-like receptor (TLR) agonist for use in a method for the treatment of a bacterial infection in a subject in need thereof wherein the TLR agonist is administered to the subject in combination with at least one antibiotic.

Abstract: Provided is a signal peptide comprising an amino acid sequence at least 90% homologous to the amino acid sequence as shown in SEQ ID NO:1. Further provided is a fusion protein comprising the signal peptide fused to a heterologous protein. Also provided are nucleic acid molecules encoding the signal peptide and encoding the fusion protein, as well as vectors and recombinant host cells comprising the nucleic acid molecules. The recombinant host cell can be a recombinant bacterium having a functional type III secretion system and having loss-of-function mutations in genes that encode secreted substrate proteins of the type III secretion system. The recombinant host cell can be used in a method of producing the heterologous protein.

Abstract: Thermoplastic moulding compositions of(1) 75 to 99 parts by weight of vinyl chloride polymers containing from 1 to 10% by weight of ethylene vinyl ester copolymers, and(2) 1 to 25 parts by weight of graft polymers of styrene and/or methyl methacrylate or of styrene and acrylonitrile and, optionally, methyl methacrylate on an ethylene-propylene terpolymer rubber.

Abstract: A thermoplastic molding composition contains a mixture of 10 to 95% by weight of a vinyl chloride polymer and 90 to 5% by weight of an adipate/carbonate mixed ester which is the transesterification reaction product of an adipate-diol polyester having terminal hydroxyls and a bifunctional carbonic acid aryl ester. The composition has a favorable combination of physical properties which include good cold fracture behavior coupled with easy processability and good ageing characteristics.

Abstract: Thermoplastic moulding compositions of(A) 20 to 99 parts by weight of a vinyl chloride homopolymer or copolymer containing at least 80% by weight of vinyl chloride and having K-values of from 50 to 80,(B) 80 to 1 part by weight of a graft polymer produced by the solution polymerization in an organic solvent of(a) styrene and/or methyl methacrylate or(b) styrene and acrylonitrile and, optionally, methyl methacrylatein the presence of an EPDM rubber.

Abstract: Polymer alloys consisting of(a) 20-90% by weight of polyvinyl chloride or copolymers of vinyl chloride with up to 30% by weight of other copolymerizable vinyl compounds, and(b) 10-80% by weight of aromatic polycarbonates.

Abstract: Polyesters containing carbonate groups and consisting of repeating structural units corresponding to the general formula ##STR1## in which X is the residue of a reaction product of a polyhydric alcohol with a polybasic aliphatic carboxylic acid having a molecular weight of from 800 to 3500,X' has the same meaning as X or represents the residue of an aliphatic polyether having a molecular weight of from 800 to 3500,n=0 or 1 to 10 andm=is a number >20,the intrinsic viscosity in tetrahydrofuran being from 0.8 to 2.5 dl/g.

Abstract: The rot-resistant plant support which is aesthetically pleasing and can be inexpensively produced consists of a rod section and a plastics material which can be colored. The interior of the rod is finely porous while the surface zone has bark-like protuberances. The plant supports are manufactured by extrusion at processing temperatures in the tool adjusted to between 5 and 30.degree. C. above the temperatures conventionally employed for extruding foams with a smooth surface from the same thermoplasts.

Abstract: Polymer mixtures consisting of:(a) 20- 90% by weight of a vinyl chloride polymer;(b) 10- 80% by weight of a polycarbonate in which at least 50% by weight of the structural units have the formula (1): ##STR1## wherein X is a single bond, --O--, --CO--, --SO.sub.2 --, C.sub.1 -C.sub.10 alkylene, C.sub.1 -C.sub.10 alkylidene, C.sub.5 -C.sub.15 cycloalkylene, C.sub.5 -C.sub.15 cycloalkylidene, C.sub.5 -C.sub.20 cycloalkyl alkylidene or ##STR2## and (C) UP TO 100% BY WEIGHT, BASED ON THE MIXTURE OF (A) AND (B) OF A RUBBER.

Abstract: Thermoplastic moulding compositions ofA. 65 to 95% by weight polyvinyl chloride or vinyl chloride copolymer having K-values of 50 to 80,B. 2 to 25% by weight of a chlorinated polyolefin or of a chlorinated olefin copolymer with a chlorine content of 20 to 80% by weight,C. 3 to 30% by weight of a graft polymer produced by grafting styrene or styrene and acrylonitrile and optionally copolymerizable monomers onto an EPDM rubber as graft base.

Abstract: The invention relates to thermoplastic molding materials, of high heat distortion point, comprising polyvinyl chloride or copolymers of vinyl chloride with other vinyl compounds, and polyphenylene oxides.The molding materials according to the invention comprises a blend consisting ofA. 30 - 90% by weight of polyvinyl chloride or of copolymers of vinyl chloride with up to about 30% by weight based on the weight of the copolymer of one or more other vinyl compounds which are copolymerizable with vinyl chloride, andB. about 10 - 70% by weight of a polyphenylene oxide.Particularly preferred molding materials comprise a blend consisting ofA. 30 - 70% by weight of polyvinyl chloride or of its copolymers with up to about 30% by weight based on the weight of the copolymer of copolymerizable vinyl compounds, andB. about 70 - 30% by weight of a polyphenylene oxide.

Abstract: Process for the production of vinyl chloride polymers modified with aromatic polycarbonate, characterized in that mixtures of olefinically unsaturated monomers containing at least 70 % by weight of vinyl chloride are polymerized by radical polymerization in the presence of aromatic polycarbonates, 0 - 100 % by weight of rubber or rubber-modified thermoplastic resin, based on the polycarbonate-modified vinyl chloride polymer, being added before or after polymerization.

Abstract: Moulding compounds with improved impact strength and weather resistance comprising mixtures of polyvinylchloride and graft polymers prepared from ethylene/vinyl ester copolymers on which have been grafted units of monomer mixtures of aromatic vinyl compounds, (meth)acrylonitrile and aliphatic monoolefins.