Patents by Inventor Dietrich Keppler

Dietrich Keppler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOUNDS FOR MODULATING INFLAMMATORY PROCESSES
    Publication number: 20100113370
    Abstract: Provided is a method of treating a patient having an inflammatory disease by using a compound which inhibits the ABCC4-mediated release of leukotrienes, a medicament containing such compound and methods for screening such compounds.
    Type: Application
    Filed: March 12, 2008
    Publication date: May 6, 2010
    Inventors: Maria Rius Montraveta, Johanna Hummel-Eisenbeiss, Dietrich Keppler
  • Quadruple Transformed Cell Line Useful for the Identification of Transport Inhibitors
    Publication number: 20080038728
    Abstract: Described is a cell line containing (a) three DNA sequences encoding different uptake transporters for organic anions, preferably OATP1B1, OATP1B3 and OATP2B1, operatively linked with a promoter and (b) a DNA sequence encoding an export pump for organic anions or anionic conjugates, preferably the multidrug resistance protein 2 (MRP2), operatively linked with a promoter. Moreover, various uses of said cell line are described, preferably for the identification of transport inhibitors, e.g. drug candidates.
    Type: Application
    Filed: October 7, 2005
    Publication date: February 14, 2008
    Inventors: Kathrin De Jong, Jorg Konig, Dietrich Keppler
  • Double-transfected cell line useful for the identification of transport inhibitors
    Patent number: 7229825
    Abstract: Described is a double-transfected cell line containing (a) a DNA sequence encoding an uptake transporter for organic anions, preferably OATP8, operatively linked with a promoter and (b) a DNA sequence encoding an export pump for organic anions or anionic conjugates, preferably the multidrug resistance protein 2 (MRP2), operatively linked with a promoter. Moreover, various uses of said cell line are described, preferably its use for the identification of transport inhibitors, e.g. drug candidates.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: June 12, 2007
    Assignee: Deutches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Yunhai Cui, Joerg Koenig, Dietrich Keppler
  • Double-transfected cell line useful for the identification of transport inhibitors
    Publication number: 20050003538
    Abstract: Described is a double-transfected cell line containing (a) a DNA sequence encoding an uptake transporter for organic anions, preferably OATP8, operatively linked with a promoter and (b) a DNA sequence encoding an export pump for organic anions or anionic conjugates, preferably the multidrug resistance protein 2 (MRP2), operatively linked with a promoter. Moreover, various uses of said cell line are described, preferably its use for the identification of transport inhibitors, e.g. drug candidates.
    Type: Application
    Filed: December 5, 2003
    Publication date: January 6, 2005
    Inventors: Yunhai Cui, Joerg Koenig, Dietrich Keppler
  • Methods for identifying and treating resistant tumors
    Patent number: 6673813
    Abstract: This invention provides a method of identifying and reversing multidrug resistance in a multidrug resistant tumor comprising administering a multidrug resistance reversing amount of any of the compounds as defined herein.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: January 6, 2004
    Inventors: Gabriele Jedlitschky, Inka Leier, Dietrich Keppler
  • Methods for identifying and treating resistant tumors
    Publication number: 20020013370
    Abstract: This invention provides a method of identifying and reversing multidrug resistance in a multidrug resistant tumor comprising administering a multidrug resistance reversing amount of any of the compounds as defined herein.
    Type: Application
    Filed: April 17, 2001
    Publication date: January 31, 2002
    Inventors: Jason Scott Sawyer, Stephen M. Spaethe, James Jacob Starling, Gabriele Jedlitschky, Inka Leier, Dietrich Keppler
  • Methods for identifying and treating resistant tumors
    Publication number: 20020010213
    Abstract: This invention provides a method of identifying and reversing multidrug resistance in a multidrug resistant tumor comprising administering a multidrug resistance reversing amount of any of the compounds as defined herein.
    Type: Application
    Filed: April 17, 2001
    Publication date: January 24, 2002
    Inventors: Jason Scott Sawyer, Stephen M. Spaethe, James Jacob Starling, Gabriele Jedlitschky, Inka Leier, Dietrich Keppler
  • Methods for identifying and treating resistant tumors
    Patent number: 6235785
    Abstract: This invention provides a method of identifying and reversing multidrug resistance in a multidrug resistance tumor comprising administering a multidrug resistance reversing amount of any of the compounds as defined herein.
    Type: Grant
    Filed: February 26, 1997
    Date of Patent: May 22, 2001
    Assignee: Eli Lilly and Company
    Inventors: Gabriele Jedlitschky, Inka Leier, Dietrich Keppler