Patents by Inventor Digant P. Dave
Digant P. Dave has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230407223Abstract: A Micro-Well Array Plates (MWAP) assembly for high throughput microfluidic devices for studying cells and method of manufacturing thereof are provided. The MWAP assembly includes a top plate having a plurality of macro-wells arranged in an array within a frame. The MWAP assembly also includes a bottom plate operable to be secured to the bottom surface of the frame, the bottom plate having a plurality of arrays of micro-wells. The MWAP assembly includes a well grid formed when the bottom plate is secured to the top plate via the plurality of macro-wells and the plurality of arrays micro-wells. The well grid with the plurality of macro-wells and the plurality of arrays micro-wells enable visualization of cells via a high throughput.Type: ApplicationFiled: October 22, 2021Publication date: December 21, 2023Applicant: The Board of Regents of The University of Texas SystemInventors: Robert M. BACHOO, Digant P. DAVÉ
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Publication number: 20230398539Abstract: A Cell Migration Assay Plates (CMAP) assembly for high throughput microfluidic migration assays and method of manufacturing thereof are provided. The CMAP assembly includes a top plate having a plurality of wells aligned with a bottom plate having a plurality of troughs. Each of the plurality of wells is defined at least in part by first and second reservoirs and a divisional wall extending between the reservoirs. The bottom plate is secured to the top plate to form a plurality of micro-channels, such that each one of the plurality of micro-channels is defined by a portion of one of the divisional walls and a portion of a corresponding one of the plurality of troughs. The plurality of micro-channels enable communication between the reservoirs and visualization of cells migrating through the micro-channels. In this manner, migration of cells through the micro-channels can be visualized for testing and screening applications.Type: ApplicationFiled: October 22, 2021Publication date: December 14, 2023Applicant: The Board of Regents of The University of Texas SystemInventors: Robert M. BACHOO, Digant P. DAVÉ
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Publication number: 20230203416Abstract: A Cell Migration Assay Plates (CMAP) assembly for high throughput microfluidic migration assays and method of manufacturing thereof are provided. The CMAP assembly includes a top plate having a plurality of wells aligned with a trough component having a plurality of troughs. Each of the wells is defined at least in part by first and second reservoirs and a divisional wall extending between the reservoirs. The trough component is secured to the top plate to form a plurality of micro-channels, such that each one of the micro-channels is defined by a portion of one of the divisional walls and a portion of a corresponding one of the plurality of troughs. The micro-channels enable communication between the reservoirs and visualization of cells migrating through the micro-channels. In this manner, migration of cells through the micro-channels can be visualized for testing and screening applications.Type: ApplicationFiled: February 20, 2023Publication date: June 29, 2023Inventors: Robert M. BACHOO, Digant P. DAVÉ
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Publication number: 20160317076Abstract: Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less than 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.Type: ApplicationFiled: April 27, 2016Publication date: November 3, 2016Inventors: Taner Akkin, Thomas E. Milner, Digant P. Dave, H. Grady Rylander, III
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Patent number: 9326719Abstract: Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.Type: GrantFiled: December 19, 2012Date of Patent: May 3, 2016Assignee: Board of Regents, The University of Texas SystemInventors: Taner Akkin, Thomas E. Milner, Digant P. Dave, H. Grady Rylander, III
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Publication number: 20140171807Abstract: Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.Type: ApplicationFiled: December 19, 2012Publication date: June 19, 2014Applicant: Board of Regents, The University of Texas SystemInventors: Taner Akkin, Thomas E. Milner, Digant P. Dave, H. Grady Rylander, III
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Patent number: 8617470Abstract: Embodiments of apparatuses, systems, and methods for label-free detection of biomolecules. In one embodiment, a system includes a light source configured to emit broadband Gaussian light. The system may also include an optical fiber coupled to the light source. Additionally, the system may include an optical sensor. The optical sensor may include a fiber-interface surface configured to be coupled to the optical fiber and to receive broadband Gaussian light from the optical fiber. The optical sensor may also include a sensor body coupled to the fiber-interface surface, the sensor body having a refractive index different from a refractive index of the optical fiber, such that at least a portion of light received by the fiber-interface surface is reflected back to the optical fiber during use; and a binder-interface surface coupled to the sensor body, the binder-interface surface configurable to receive a chemical binder layer.Type: GrantFiled: November 10, 2010Date of Patent: December 31, 2013Assignee: Board of Regents, The University of Texas SystemInventor: Digant P. Davé
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Patent number: 8352022Abstract: Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.Type: GrantFiled: March 4, 2010Date of Patent: January 8, 2013Assignee: Board of Regents, The University of Texas SystemInventors: Taner Akkin, Thomas E. Milner, Digant P. Dave, H. Grady Rylander
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Publication number: 20110171072Abstract: Embodiments of apparatuses, systems, and methods for label-free detection of biomolecules. In one embodiment, a system includes a light source configured to emit broadband Gaussian light. The system may also include an optical fiber coupled to the light source. Additionally, the system may include an optical sensor. The optical sensor may include a fiber-interface surface configured to be coupled to the optical fiber and to receive broadband Gaussian light from the optical fiber. The optical sensor may also include a sensor body coupled to the fiber-interface surface, the sensor body having a refractive index different from a refractive index of the optical fiber, such that at least a portion of light received by the fiber-interface surface is reflected back to the optical fiber during use; and a binder-interface surface coupled to the sensor body, the binder-interface surface configurable to receive a chemical binder layer.Type: ApplicationFiled: November 10, 2010Publication date: July 14, 2011Applicant: The Board of Regents of The University of Texas SystemInventor: Digant P. Davé
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Publication number: 20100249609Abstract: Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.Type: ApplicationFiled: March 4, 2010Publication date: September 30, 2010Applicant: Board of Regents, the University of Texas SystemInventors: Taner AKKIN, Thomas E. Milner, Digant P. Dave, H. Grady Rylander
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Patent number: 7711416Abstract: Optical methods, devices, and systems for non-invasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflection coatings are not required. Transient neural surface displacement of less than 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.Type: GrantFiled: May 24, 2005Date of Patent: May 4, 2010Assignee: Volcano CorporationInventors: Taner Akkin, Digant P. Dave, Thomas E. Milner, H. Grady Rylander, III
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Patent number: 7177491Abstract: Generally, and in one form of the present invention, is a polarization-maintaining fiber-based polarization sensitive optical low coherence reflectometer for depth resolved birefringence measurement. With the present invention, linear birefringence of a sample may be measured from data recorded in a single A-Scan. In addition, the present invention provides for the simultaneous measurement of retardation and orientation of birefringent axes, wherein measured retardation is insensitive to sample rotation in the plane perpendicular to ranging.Type: GrantFiled: October 6, 2003Date of Patent: February 13, 2007Assignee: Board of Regents the University of Texas SystemInventors: Digant P. Dave, Thomas E. Milner, Taner Akkin
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Publication number: 20040126048Abstract: Generally, and in one form of the present invention, is a polarization-maintaining fiber-based polarization sensitive optical low coherence reflectometer for depth resolved birefringence measurement. With the present invention, linear birefringence of a sample may be measured from data recorded in a single A-Scan. In addition, the present invention provides for the simultaneous measurement of retardation and orientation of birefringent axes, wherein measured retardation is insensitive to sample rotation in the plane perpendicular to ranging.Type: ApplicationFiled: October 6, 2003Publication date: July 1, 2004Inventors: Digant P. Dave, Thomas E. Milner, Taner Akkin
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Patent number: 6665456Abstract: One form of the present invention is a dual channel optical reflectometer composed of a birefringent path coupler and an optical source path that is optically connected to the path coupler. After entering the path coupler, light is split into birefringent reference and sample paths. The reference path is optically aligned with a first collimating lens, and the collimating lens is directed into a scanning delay line. There is also a birefringent optical sample path that is also optically connected to the path coupler. The sample path is optically aligned with a polarization channel separator/combiner and a lens, to focus and direct optical beams into the turbid sample. Light backscattered from the turbid sample is collected by the second lens and orthogonal polarization channels are reunited by the polarization channel combiner. An analog-to-digital converter is connected to the amplifier, and a computer is connected to the analog-to-digital converter to analyze the output.Type: GrantFiled: January 11, 2002Date of Patent: December 16, 2003Assignee: Board of Regents, The University of Texas SystemInventors: Digant P. Dave, Thomas E. Milner, Sergey Telenkov
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Publication number: 20030020920Abstract: One form of the present invention is a dual channel optical reflectometer composed of a birefringent path coupler and an optical source path that is optically connected to the path coupler. After entering the path coupler, light is split into birefringent reference and sample paths. The reference path is optically aligned with a first collimating lens, and the collimating lens is directed into a scanning delay line. There is also a birefringent optical sample path that is also optically connected to the path coupler. The sample path is optically aligned with a polarization channel separator/combiner and a lens, to focus and direct optical beams into the turbid sample. Light backscattered from the turbid sample is collected by the second lens and orthogonal polarization channels are reunited by the polarization channel combiner. An analog-to-digital converter is connected to the amplifier, and a computer is connected to the analog-to-digital converter to analyze the output.Type: ApplicationFiled: January 11, 2002Publication date: January 30, 2003Inventors: Digant P. Dave, Thomas E. Milner, Sergey Telenkov