Patents by Inventor Dik-Lung Ma

Dik-Lung Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of using metal complexes to promote wound healing
    Patent number: 11958868
    Abstract: Method of inhibiting a protein-protein interaction between Von Hippel-Lindau tumor-suppressor protein and hypoxia-inducible factor 1-alpha useful in the treatment of angiogenesis-related diseases and promoting wound healing.
    Type: Grant
    Filed: June 7, 2022
    Date of Patent: April 16, 2024
    Assignees: University of Macau, Hong Kong Baptist University
    Inventors: Chung Hang Leung, Dik Lung Ma, Ligen Lin, Guodong Li, Chung Nga Ko, Dan Li, Chao Yang
  • METHODS OF USING METAL COMPLEXES TO PROMOTE WOUND HEALING
    Publication number: 20230391810
    Abstract: Method of inhibiting a protein-protein interaction between Von Hippel-Lindau tumor-suppressor protein and hypoxia-inducible factor 1-alpha useful in the treatment of angiogenesis-related diseases and promoting wound healing.
    Type: Application
    Filed: June 7, 2022
    Publication date: December 7, 2023
    Inventors: Chung Hang LEUNG, Dik Lung MA, Ligen LIN, Guodong LI, Chung Nga KO, Dan LI, Chao YANG
  • One-step strategy for ultra-fast and low cost mass production of plastic membrane microfluidic chips
    Patent number: 10632688
    Abstract: A method for fabricating flexible microfluidic chips with plastic membranes. In particular, the present invention provides a single-step method for microchannel fabrication of microfluidic chips in a fast and cost-efficient manner.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: April 28, 2020
    Assignees: Hong Kong Baptist University, THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Kangning Ren, Dik-Lung Ma, Chong Hu, Wanbo Li, Sheng Lin, Hongkai Wu
  • Development of lead ion testing paper with naked-eye observable readout for ten min on-site detection
    Patent number: 10151699
    Abstract: A luminescent Ir(III) complex is used to develop a label-free G-quadruplex-based assay for lead ions in liquid or solution. In particular, the present invention describes method for monitoring lead ion concentration in water.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: December 11, 2018
    Assignees: Hong Kong Baptist University, University of Macau
    Inventors: Dik-Lung Ma, Chung-Hang Leung, Kangning Ren
  • Luminescent Iridium(III) complex and its uses thereof for the G-quadruplex-based switch-on rapid detection of lead ions
    Patent number: 10145825
    Abstract: A luminescent Ir(III) complex it used to develop a label-free G-quadruplex-based assay for lead ions in a liquid or aqueous solution. In particular, the present invention describes method for monitoring lead ion concentration in water.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: December 4, 2018
    Assignees: Hong Kong Baptist University, University of Macau
    Inventors: Dik-Lung Ma, Sheng Lin, Chung-Hang Leung
  • One-Step Strategy for Ultra-Fast and Low Cost Mass Production of Plastic Membrane Microfluidic Chips
    Publication number: 20180236719
    Abstract: A method for fabricating flexible microfluidic chips with plastic membranes. In particular, the present invention provides a single-step method for microchannel fabrication of microfluidic chips in a fast and cost-efficient manner.
    Type: Application
    Filed: February 14, 2018
    Publication date: August 23, 2018
    Inventors: Kangning REN, Dik-Lung MA, Chong HU, Wanbo LI, Sheng LIN, Hongkai WU
  • Iridium(III)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent
    Patent number: 9840526
    Abstract: Bromodomain-containing protein 4 (BRI)) has recently emerged as an attractive epigenetic target for anticancer therapy. Iridium(III) complexes are useful as irreversible inhibitor of BRD4. Complex 1a of the formula: is particularly useful.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: December 12, 2017
    Assignees: University of Macau, Hong Kong Baptist University, Kaohsiung Medical University
    Inventors: Chung-Hang Leung, Hai-Jing Zhong, Dik-Lung Ma, Hui-Min Wang
  • METHOD OF DETECTING HELICASE ACTIVITY
    Publication number: 20170145472
    Abstract: The present invention provides a method of detecting helicase activity in a test solution, providing a substrate solution containing a double-stranded DNA, wherein said double-stranded DNA is a substrate for a helicase to be detected; (b) introducing the substrate solution to the test solution to form a reaction solution; (c) applying a luminescent probe into the reaction solution to form a mixture; and (d) measuring a luminescent response of the luminescent probe in the mixture, wherein the luminescent response corresponds to the helicase activity in the test solution. The present invention also refers to a method of screening a potent luminescent probe for detecting helicase activity, and a series of luminescent Ir (III) complexes.
    Type: Application
    Filed: November 24, 2015
    Publication date: May 25, 2017
    Inventors: Dik-Lung Ma, Chung-Hang Leung, Hai-Jing Zhong, Bingyong He
  • Method for antagonizing STAT3 dimerization and compounds for use therein
    Patent number: 9657044
    Abstract: A compound of the formula: Also, a method for antagonizing STAT3 dimerization in a patient in need thereof which by administering to such patient a therapeutically acceptable dose of the compound of Formula I. Further, a method for treating a cancer patient in need thereof by administering a therapeutically effective dose of the compound of Formula I.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: May 23, 2017
    Assignees: University of Macau, Hong Kong Baptist University, Kaohsiung Medical University
    Inventors: Chung-Hang Leung, Dik-Lung Ma, Hui-Min Wang
  • Development of lead ion testing paper with naked-eye observable readout for ten min on-site detection
    Publication number: 20170102330
    Abstract: A luminescent Ir(III) complex is used to develop a label-free G-quadruplex-based assay for lead ions in liquid or solution. In particular, the present invention describes method for monitoring lead ion concentration in water.
    Type: Application
    Filed: October 12, 2016
    Publication date: April 13, 2017
    Inventors: Dik-Lung MA, Chung-Hang LEUNG, Kangning REN
  • Luminescent Iridium(III) complex and its uses thereof for the G-quadruplex-based switch-on rapid detection of lead ions
    Publication number: 20170102331
    Abstract: A luminescent Ir(III) complex it used to develop a label-free G-quadruplex-based assay for lead ions in a liquid or aqueous solution. In particular, the present invention describes method for monitoring lead ion concentration in water.
    Type: Application
    Filed: October 11, 2016
    Publication date: April 13, 2017
    Inventors: Dik-Lung MA, Sheng LIN, Chung-Hang LEUNG
  • METHOD FOR ANTAGONIZING STAT3 DIMERIZATION AND COMPOUNDS FOR USE THEREIN
    Publication number: 20160347779
    Abstract: A compound of the formula: Also, a method for antagonizing STAT3 dimerization in a patient in need thereof which by administering to such patient a therapeutically acceptable dose of the compound of Formula I. Further, a method for treating a cancer patient in need thereof by administering a therapeutically effective dose of the compound of Formula I.
    Type: Application
    Filed: May 31, 2016
    Publication date: December 1, 2016
    Applicants: University of Macau, Hong Kong Baptist University, Kaohsiung Medical University
    Inventors: Chung-Hang Leung, Dik-Lung Ma, Hui-Min Wang
  • Luminescent protein staining
    Patent number: 8318498
    Abstract: The present invention relates to the use of cyclometalated iridium complexes for detecting poly(amino acids) including peptides, polypeptides, and proteins. Poly(amino acids) are detected in solution, in electrophorectic gels, and on solid supports, including blots. The method of the present invention is rapid, highly sensitive, and extremely facile.
    Type: Grant
    Filed: October 9, 2007
    Date of Patent: November 27, 2012
    Assignee: The Hong Kong Polytechnic University
    Inventors: Kwok-Yin Wong, Dik-Lung Ma, Wing-Leung Wong, Wai-Hong Chung, Fung-Yi Chan
  • Luminescent Protein Staining
    Publication number: 20090093060
    Abstract: The present invention relates to the use of cyclometalated iridium complexes for detecting poly(amino acids) including peptides, polypeptides, and proteins. Poly(amino acids) are detected in solution, in electrophorectic gels, and on solid supports, including blots. The method of the present invention is rapid, highly sensitive, and extremely facile.
    Type: Application
    Filed: October 9, 2007
    Publication date: April 9, 2009
    Applicant: The Hong Kong Polytechnic University
    Inventors: Kwok-yin Wong, Dik-lung Ma, Wing-leung Wong, Wai-hong Chung, Fung-yi Chan