Patents by Inventor Dileep K. PULUKKUNAT

Dileep K. PULUKKUNAT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FLUORESCENCE-BASED APPROACH TO MONITOR RELEASE FACTOR-CATALYZED TERMINATION OF PROTEIN SYNTHESIS
    Publication number: 20130034914
    Abstract: Provided are probes comprising a class 1 release factor conjugated to a fluorescent label and methods of making the probes. Also provided are methods for detecting conformational changes in ribosomes and associated molecules, such as class 1 release factors. In addition, methods of identifying a compound for reducing nonsense-mediated decay of mRNA and/or for inhibiting termination of protein synthesis at a premature stop codon, are described. Methods of assaying RF3 activity are also included.
    Type: Application
    Filed: February 28, 2012
    Publication date: February 7, 2013
    Inventors: Ruben L. GONZALEZ, JR., Samuel H. STERNBERG, Dileep K. PULUKKUNAT