Abstract: The present invention relates to a freeze-dried formulation for cephalosporin derivatives having increased stability and a method for preparing such a formulation using certain excipients for stabilizing the formulation.

Abstract: The present invention provides a composition comprising a sustained release layer and a fast release layer. The sustained release layer comprises a water-soluble polymer and a first pharmaceutically active agent. The fast release layer comprises a matrix forming agent and a second pharmaceutically active agent. Generally, the composition provides fast and sustained (or controlled) release of a pharmaceutically active agent for at least 6 hours and preferably for at least 1 to 3 days. The composition may be incorporated into a dosage unit form, such as a vaginal insert. Methods of preparing the composition are also provided.

Abstract: The present invention is directed to a taste-masked resinate that contains a water-insoluble active substance complexed to an ion-exchange resin in a taste-masking effective amount. The taste-masked resinate is useful in the manufacture of a dosage form such as a rapid-disintegrating tablet, a rapid-disintegrating film, an effervescent tablet, a chewable tablet, a chewing gum, a suspension, a sprinkle granule, a powder for reconstitution in a suspension and the like and a method for the preparation thereof.