Patents by Inventor Dilip Ramda Birari
Dilip Ramda Birari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11267798Abstract: The present application relates to a process for the preparation of piperine of high purity having low concentrations of isomeric impurities.Type: GrantFiled: October 13, 2018Date of Patent: March 8, 2022Assignee: CIPLA LIMITEDInventors: Manjinder Singh Phull, Dharmaraj Ramachandra Rao, Geena Malhortra, Dilip Ramdas Birari, Sachin Vasant Desai
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Publication number: 20210363126Abstract: The present application relates to a process for the preparation of piperine of high purity having low concentrations of isomeric impurities.Type: ApplicationFiled: October 13, 2018Publication date: November 25, 2021Inventors: Manjinder Singh PHULL, Dharmaraj Ramachandra RAO, Geena MALHORTRA, Dilip Ramdas BIRARI, Sachin Vasant DESAI
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Patent number: 9150499Abstract: The present invention relates to a process for the preparation of substantially pure nateglinide of formula (I), substantially free from the cis-isomer and L-enantiomer and preparation of enantiomerically pure nateglinide form B, directly from the hydrolysis of a (?)-N-(trans-4-isopropylcyclohexyl-1-carbonyl)-D-phenylalanine alkyl ester in a ketonic solvent or water or mixture thereof.Type: GrantFiled: June 14, 2011Date of Patent: October 6, 2015Assignee: Cipla LimitedInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Dilip Ramdas Birari
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Publication number: 20150080579Abstract: The present invention provides dexrabeprazole magnesium hydrate and a process for its preparation. The present invention also provides a magnesium, calcium or potassium salt of dexrabeprazole, optionally in amorphous form, and processes for its preparation.Type: ApplicationFiled: November 19, 2014Publication date: March 19, 2015Inventors: Dharmaraj Ramachandra RAO, Rajendra Narayanrao KANKAN, Srinivas Laxminarayan PATHI, Dilip Ramdas BIRARI
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Patent number: 8912337Abstract: The present invention provides dexrabeprazole magnesium hydrate and a process for its preparation. The present invention also provides a magnesium, calcium or potassium salt of dexrabeprazole, optionally in amorphous form, and processes for its preparation.Type: GrantFiled: June 24, 2011Date of Patent: December 16, 2014Assignee: Cipla LimitedInventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Dilip Ramdas Birari
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Patent number: 8658821Abstract: A one-pot process for the preparation of nateglinide, which process comprises reacting an alkyl ester of D-phenylalanine of formula (II): where R represents C1-4alkyl, typically methyl, either as the free base or in salt form (typically the hydrochloride), with trans-4-isopropylcyclohexanecarboxylic acid of formula (III): where X represents hydroxy or halo, typically chloro, to obtain a C1-4 alkyl ester of nateglinide of formula (IV), preferably the methyl ester of nateglinide: followed by hydrolysis to yield nateglinide of formula (I):Type: GrantFiled: June 8, 2005Date of Patent: February 25, 2014Assignee: Cipla LimitedInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Manjinder Singh Phull, Dilip Ramdas Birari
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Patent number: 8575393Abstract: There is provided a process for preparing a salt of the (R)- or (S)-isomer of 1-naphthylethylamine with mandelic acid or a derivative thereof, the process comprising reacting racemic 1-naphthylethylamine with mandelic acid or a derivative thereof to obtain the (R)- or (S)-isomer of 1-naphthylethylamine salt (III) with the acid. The salts also form an aspect of the present invention. There is also provided a salt of the (R)- or (S)-isomer of 1-naphthylethylamine with mandelic acid or a derivative thereof. There is also provided a process for preparing cinacalcet (I) or a salt thereof, the process comprising reacting an ester (II) with (R)-1-naphthylethylamine or a salt of (R)-1-naphthylethylamine and mandelic acid or a derivative thereof, to obtain cinacalcet, and optionally converting the cincalcet to a salt thereof.Type: GrantFiled: March 4, 2010Date of Patent: November 5, 2013Assignee: CIPLA LimitedInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Dilip Ramdas Birari
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Publication number: 20130165686Abstract: The present invention relates to a process for the preparation of substantially pure nateglinide of formula (I), substantially free from the cis-isomer and L-enantiomer and preparation of enantiomerically pure nateglinide form B, directly from the hydrolysis of a (?)-N-(trans-4-isopropylcyclohexyl-1-carbonyl)-D-phenylalanine alkyl ester in a ketonic solvent or water or mixture thereof.Type: ApplicationFiled: June 14, 2011Publication date: June 27, 2013Applicant: CIPLA LIMITEDInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Dilip Ramdas Birari
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Publication number: 20130150588Abstract: The present invention provides dexrabeprazole magnesium hydrate and a process for its preparation. The present invention also provides a magnesium, calcium or potassium salt of dexrabeprazole, optionally in amorphous form, and processes for its preparation.Type: ApplicationFiled: June 24, 2011Publication date: June 13, 2013Applicant: CIPLA LIMITEDInventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Dilip Ramdas Birari
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Patent number: 8426590Abstract: The present invention relates to a process for the preparation of doxazosin or salts thereof.Type: GrantFiled: March 23, 2010Date of Patent: April 23, 2013Assignee: Cipla LimitedInventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Dilip Ramdas Birari
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Patent number: 8288568Abstract: The present invention provides a novel process for the preparation of a compound of Formula III, and novel processes for preparing escitalopram using the compound of Formula III.Type: GrantFiled: May 16, 2008Date of Patent: October 16, 2012Assignee: Cipla LimitedInventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Dilip Ramdas Birari, Manjinder Singh Phull
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Patent number: 8247434Abstract: Anhydrous crystalline fexofenadine hydrochloride Form C, crystalline fexofenadine acetate monohydrate Form D, crystalline fexofenadine acetate dihydrate Form E and crystalline fexofenadine free base monohydrate Form F, processes of preparing the same, pharmaceutical compositions thereof, therapeutic uses thereof and methods of treatment therewith.Type: GrantFiled: November 19, 2008Date of Patent: August 21, 2012Assignee: Cipla LimitedInventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manish Gopaldas Gangrade, Dilip Ramdas Birari
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Patent number: 8183269Abstract: The present invention relates to a process for the preparation of rufinamide of formula I, which process comprises: (i) reacting a 2,6-difluorobenzylhalide of formula II, wherein X is chloride, bromide or iodide, with an azide to obtain 2-(azidomethyl)-1,3-difluorobenzene of formula III; (ii) reacting 2-(azidomethyl)-1,3-difluorobenzene of formula III with methyl propiolate to obtain methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate of formula IV; and (iii) reacting methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate of formula IV with ammonia to obtain rufinamide of formula I.Type: GrantFiled: October 9, 2009Date of Patent: May 22, 2012Assignee: CIPLA LimitedInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Dilip Ramdas Birari
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Publication number: 20120053362Abstract: There is provided a process for preparing a salt of the (R)- or (S)-isomer of 1-naphthylethylamine with mandelic acid or a derivative thereof, the process comprising reacting racemic 1-naphthylethylamine with mandelic acid or a derivative thereof to obtain the (R)- or (S)-isomer of 1-naphthylethylamine salt (III) with the acid. The salts also form an aspect of the present invention. There is also provided a salt of the (R)- or (S)-isomer of 1-naphthylethylamine with mandelic acid or a derivative thereof. There is also provided a process for preparing cinacalcet (I) or a salt thereof, the process comprising reacting an ester (II) with (R)-1-naphthylethylamine or a salt of (R)-1-naphthylethylamine and mandelic acid or a derivative thereof, to obtain cinacalcet, and optionally converting the cincalcet to a salt thereof.Type: ApplicationFiled: March 4, 2010Publication date: March 1, 2012Applicant: CIPLA LIMITEDInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Dilip Ramdas Birari
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Publication number: 20120041199Abstract: The present invention relates to a process for the preparation of doxazosin or salts thereof.Type: ApplicationFiled: March 23, 2010Publication date: February 16, 2012Applicant: CIPLA LIMITEDInventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Dilip Ramdas Birari
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Publication number: 20110207938Abstract: The present invention relates to a process for the preparation of rufinamide of formula I, which process comprises: (i) reacting a 2,6-difluorobenzylhalide of formula II, wherein X is chloride, bromide or iodide, with an azide to obtain 2-(azidomethyl)-1,3-difluorobenzene of formula III; (ii) reacting 2-(azidomethyl)-1,3-difluorobenzene of formula III with methyl propiolate to obtain methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid of formula IV; and (iii) reacting methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid of formula IV with ammonia to obtain rufinamide of formula I.Type: ApplicationFiled: October 13, 2009Publication date: August 25, 2011Applicant: CIPLA LIMITEDInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Dilip Ramdas Birari
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Patent number: 7973173Abstract: A process for the synthesis of trandolapril which comprises condensing N—[I—(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride with trans octahydro-1H-indole-2-carboxylic acid in a first organic solvent comprising a water immiscible inert organic solvent and in the presence of a base, and isolating trandolapril from a second organic solvent. N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride may also be condensed with (2S,3aR,7aS) octahydro-1H-indole-2-carboxylic acid in a first organic solvent and in the presence of a base, and trandolapril isolated. There is also provided a process for the resolution of racemic trans octahydro-1H-indole-2-carboxylc acid.Type: GrantFiled: July 5, 2006Date of Patent: July 5, 2011Assignee: Cipla LimitedInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Manjinder Singh Phull, Ashwini Sawant, Dilip Ramdas Birari
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Publication number: 20100204493Abstract: The present invention provides a novel process for the preparation of a compound of Formula III, and novel processes for preparing escitalopram using the compound of Formula III.Type: ApplicationFiled: May 16, 2008Publication date: August 12, 2010Applicant: CIPLA LIMITEDInventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Dilip Ramdas Birari, Manjinder Singh Phull
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Patent number: 7678916Abstract: The present invention relates to processes for the preparation of rosiglitazone, rosiglitazone prepared thereby and pharmaceutical compositions and therapeutic uses thereof, and methods of treatment employing the same.Type: GrantFiled: August 13, 2004Date of Patent: March 16, 2010Assignee: Cipla LimitedInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Manjinder Singh Phull, Dilip Ramda Birari
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Publication number: 20090221830Abstract: Anhydrous crystalline fexofenadine hydrochloride Form C, crystalline fexofenadine acetate monohydrate Form D, crystalline fexofenadine acetate dihydrate Form E and crystalline fexofenadine free base monohydrate Form F, processes of preparing the same, pharmaceutical compositions thereof, therapeutic uses thereof and methods of treatment therewith.Type: ApplicationFiled: November 19, 2008Publication date: September 3, 2009Applicant: Cipla LimitedInventors: Dharmaraj Ramachandra RAO, Rajendra Narayanrao KANKAN, Manish Gopaldas GANGRADE, Dilip Ramdas BIRARI