Patents by Inventor Dilyana Aleksandrova TODOROVA

Dilyana Aleksandrova TODOROVA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIVER MICROTISSUE AND USES IN TREATMENT OF LIVER FAILURE
    Publication number: 20230357725
    Abstract: The invention relates to a liver microtissue, preferably, the liver microtissue having the largest dimension between 500 and 700 ?m, and the liver microtissue expressing CYP3A4 monooxygenase with an activity of at least 75,000 RLU per million cells and producing at least 18 ag of urea per million cells per 24 hours. The invention also relates to a method for producing the liver microtissue from pluripotent stem cells, and uses of the liver microtissue in treatment and/or prevention of liver failure.
    Type: Application
    Filed: November 30, 2022
    Publication date: November 9, 2023
    Inventors: Maxime FEYEUX, Dilyana Aleksandrova TODOROVA, Elise laure WARTER
  • LIVER MICROTISSUE FOR TREATING LIVER FAILURE
    Publication number: 20230355683
    Abstract: The invention relates to a liver microtissue, preferably a liver microtissue comprising at least 3 different phenotypes of liver cells obtained from induced pluripotent stem cells encapsulated in a single three-dimensional closed microcompartment. The invention also relates to a method for preparing the liver microtissue and its uses in treatment or prevention of liver failure.
    Type: Application
    Filed: November 30, 2022
    Publication date: November 9, 2023
    Inventors: Maxime FEYEUX, Dilyana Aleksandrova TODOROVA, Elise laure WARTER