Abstract: A tissue treatment system includes an applicator connected with a base unit. The applicator includes a light source to generate light energy. A light guide directs the light energy to biological tissue and is configured to contact biological tissue. A thermoelectric cooler has a cold side and a hot side, with the cold side being associated with the light guide. A hot side plate is mounted to the hot side of the thermoelectric cooler. A first fluid passage is between the reservoir and the hot side plate to deliver cooling fluid over the hot side plate to chill the cold side of the thermoelectric cooler and cool the light guide and biological tissue. A second fluid passage is associated with the light source to direct cooling fluid to the light source prior to being returned to the reservoir. The first and second fluid passages define a single cooling fluid circulation loop.

Abstract: A tissue treatment system includes an applicator connected with a base unit. The applicator includes a light source to generate light energy. A light guide directs the light energy to biological tissue and is configured to contact biological tissue. A thermoelectric cooler has a cold side and a hot side, with the cold side being associated with the light guide. A hot side plate is mounted to the hot side of the thermoelectric cooler. A first fluid passage is between the reservoir and the hot side plate to deliver cooling fluid over the hot side plate to chill the cold side of the thermoelectric cooler and cool the light guide and biological tissue. A second fluid passage is associated with the light source to direct cooling fluid to the light source prior to being returned to the reservoir. The first and second fluid passages define a single cooling fluid circulation loop.

Abstract: A single fill valve for a cryogenic liquid storage vessel. The valve includes a central opening configured to receive a cryogenic liquid and distal and bottom openings configured to direct cryogenic liquid into the cryogenic liquid storage vessel. The valve further includes a plunger and a pin configured to move the plunger and block at least the distal and bottom openings of the single use valve.

Abstract: A single fill valve for a cryogenic liquid storage vessel. The valve includes a central opening configured to receive a cryogenic liquid and distal and bottom openings configured to direct cryogenic liquid into the cryogenic liquid storage vessel. The valve further includes a plunger and a pin configured to move the plunger and block at least the distal and bottom openings of the single use valve.