Patents by Inventor Dimitar B. Nikilov

Dimitar B. Nikilov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Active-site engineering of nucleotidylyltransferases and general enzymatic methods for the synthesis of natural and “unnatural” UDP- and TDP-nucleotide sugars
    Patent number: 7906460
    Abstract: The present invention provides mutant nucleotidylyl-transferases, such as Ep, having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified Ep or other nucleotidyltransferases; and nucleotide sugars synthesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.
    Type: Grant
    Filed: September 28, 2006
    Date of Patent: March 15, 2011
    Assignee: Sloan-Kettering Institute for Cancer
    Inventors: Jon Thorson, Dimitar B. Nikilov
  • Active-site engineering of nucleotidylyltransferases and general enzymatic methods for the synthesis of natural and “unnatural” UDP- and TDP-nucleotide sugars
    Patent number: 7122359
    Abstract: The present invention provides mutant nucleotidylyl-transferases, such as Ep, having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified Ep or other nucleotidyltransferases; and nucleotide sugars sythesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.
    Type: Grant
    Filed: December 13, 2001
    Date of Patent: October 17, 2006
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Jon Thorson, Dimitar B. Nikilov
  • Active-site engineering of nucleotidylyltransferases and general enzymatic methods for the synthesis of natural and "unnatural" UDP- and TDP-nucleotide sugars
    Publication number: 20030055235
    Abstract: The present invention provides mutant nucleotidylyl-transferases, such as Ep, having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified Ep or other nucleotidyltransferases; and nucleotide sugars sythesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.
    Type: Application
    Filed: December 13, 2001
    Publication date: March 20, 2003
    Inventors: Jon Thorson, Dimitar B. Nikilov