Patents by Inventor Dimitri Coucouvanis

Dimitri Coucouvanis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies
    Patent number: 7888389
    Abstract: Disclosed are copper-binding compounds with improved properties and methods of using such compounds in the prevention and treatment of angiogenic diseases, such as cancer. Advantages of the invention include the enhanced stability of the compounds, which is achieved without reduction in efficacy. Pharmaceutical compositions, therapeutic kits and combination treatment methods and uses are also provided.
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: February 15, 2011
    Assignee: The Regents of the University of Michigan
    Inventors: George J. Brewer, Sofia D. Merajver, Dimitri Coucouvanis
  • Methods and compositions for the treatment of angiogenic diseases
    Patent number: 7438931
    Abstract: Provided are agents that can bind to copper, and form a tripartite complex with protein, and the use of these agents in the prevention and treatment of diseases with a vascular component, such as solid tumors. Compositions and methods for combination therapy of these diseases, including cancer, as well as therapeutic kits, are also provided.
    Type: Grant
    Filed: March 9, 2004
    Date of Patent: October 21, 2008
    Assignee: The Regents of The University of Michigan
    Inventors: George J. Brewer, Sofia D. Merajver, Dimitri Coucouvanis
  • Thiomolybdate analogues and uses thereof
    Patent number: 7189865
    Abstract: The current invention provides novel thiomolybdate derivatives, methods of making novel thiomolybdate derivatives, pharmaceutical compositions of novel thiomolybdate derivatives, methods of using novel thiomolybdate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-?B dysregulation and methods of using pharmaceutical compositions of thiomolybdate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-?B dysregulation.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: March 13, 2007
    Assignees: Attenuon, LLC, Regents of the University of Michigan
    Inventors: Robert J. Ternansky, Andrew Mazar, Patricia L. Gladstone, Dimitri Coucouvanis, Amy L. Allan, Sean M. O'Hare, Melissa L. P. Price, Steven Robert Pirie-Shepherd, Fernando Donate
  • Methods and compositions for the treatment of angiogenic diseases
    Publication number: 20050058720
    Abstract: Provided are agents that can bind to copper, and form a tripartite complex with protein, and the use of these agents in the prevention and treatment of diseases with a vascular component, such as solid tumors. Compositions and methods for combination therapy of these diseases, including cancer, as well as therapeutic kits, are also provided.
    Type: Application
    Filed: March 9, 2004
    Publication date: March 17, 2005
    Inventors: George Brewer, Sofia Merajver, Dimitri Coucouvanis
  • Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies
    Publication number: 20040259945
    Abstract: Disclosed are copper-binding compounds with improved properties and methods of using such compounds in the prevention and treatment of angiogenic diseases, such as cancer. Advantages of the invention include the enhanced stability of the compounds, which is achieved without reduction in efficacy. Pharmaceutical compositions, therapeutic kits and combination treatment methods and uses are also provided.
    Type: Application
    Filed: July 23, 2003
    Publication date: December 23, 2004
    Applicant: The Regents of The University of Michigan
    Inventors: George J. Brewer, Sofia D. Merajver, Dimitri Coucouvanis
  • Methods and compositions for the prevention or treatment of cancer
    Patent number: 6703050
    Abstract: Provided are agents that can bind to copper, and form a tripartite complex with protein, and the use of these agents in the prevention and treatment of diseases with a vascular component, such as solid tumors. Compositions and methods for combination therapy of these diseases, including cancer, as well as therapeutic kits, are also provided.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: March 9, 2004
    Assignee: The Regents of the University of Michigan
    Inventors: George J. Brewer, Sofia D. Merajver, Dimitri Coucouvanis
  • Thiomolybdate analogues and uses thereof
    Publication number: 20040019087
    Abstract: The current invention provides novel thiomolybdate derivatives, methods of making novel thiomolybdate derivatives, pharmaceutical compositions of novel thiomolybdate derivatives, methods of using novel thiomolybdate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-&kgr;B dysregulation and methods of using pharmaceutical compositions of thiomolybdate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-&kgr;B dysregulation.
    Type: Application
    Filed: May 28, 2003
    Publication date: January 29, 2004
    Inventors: Robert J. Ternansky, Andrew Mazar, Patricia L. Gladstone, Dimitri Coucouvanis, Amy L. Allan, Sean M. O'Hare, Melissa L.P. Price, Steven Robert Pirie-Shepherd, Fernando Donate
  • Thiomolybdate analogues and uses thereof
    Publication number: 20040019043
    Abstract: The current invention provides novel thiomolybdate derivatives, methods of making novel thiomolybdate derivatives, pharmaceutical compositions of novel thiomolybdate derivatives, methods of using novel thiomolybdate derivatives to treat diseases associated with aberrant vascularization and methods of using pharmaceutical compositions of thiomolybdate derivatives to treat diseases associated with aberrant vascularization.
    Type: Application
    Filed: July 23, 2002
    Publication date: January 29, 2004
    Inventors: Dimitri Coucouvanis, Robert J. Ternansky, Patricia L. Gladstone, Amy L. Allan, Melissa L.P. Price, Sean M. O'Hare
  • Salicylaldimine-crown ether ditopic receptor molecules
    Patent number: 6111123
    Abstract: The present invention relates generally to carriers for transport of amino acid, amino acid derivatives and other biologically important molecules such as catecholamines and neurotransmitters. In particular, the present invention relates to ditopic receptor molecules that contain salicylaldimine and crown-ether subunits, and complexed to metal ions. The compounds of the present invention were shown to have efficient transport properties for zwitterions.
    Type: Grant
    Filed: April 20, 1998
    Date of Patent: August 29, 2000
    Assignee: The Regents of the University of Michigan
    Inventors: Dimitri Coucouvanis, Dell Rosa