Patents by Inventor Dimitri Denisov

Dimitri Denisov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mapping and reconstitution of a conformational discontinuous binding surface
    Patent number: 7587281
    Abstract: The structure of conformational, discontinuous binding surfaces that associate with a binding molecule, preferably the epitopes of monoclonal antibodies (mAbs) may be discovered. The binding molecule is used to select specific peptides from a peptide library that, in turn, are used as a binding surface (epitope) defining database that is applied via a novel computer algorithm to analyze the crystalline-structure of the original binding surface (antigen). An antigenic epitope-mimetic that is recognized by its original mAb may be reconstituted based on the segments of the epitope identified in the prediction. The basic elements of the binding domain on gp120 that is recognized by broadly neutralizing antibody b12 are disclosed, as in their use in making vaccines for preventing or treating HIV.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: September 8, 2009
    Assignee: Ramot At Tel Aviv University
    Inventors: Jonathan M. Gershoni, Erez Bublil, Dimitri Denisov, Galina Denisova
  • Mapping and reconstitution of a conformational discontinuous binding surface
    Publication number: 20070005262
    Abstract: The structure of conformational, discontinuous binding surfaces that associate with a binding molecule, preferably the epitopes of monoclonal antibodies (mAbs) may be discovered. The binding molecule is used to select specific peptides from a peptide library that, in turn, are used as a binding surface (epitope) defining database that is applied via a novel computer algorithm to analyze the crystalline-structure of the original binding surface (antigen). An antigenic epitope-mimetic that is recognized by its original mAb may be reconstituted based on the segments of the epitope identified in the prediction. The basic elements of the binding domain on gp120 that is recognized by broadly neutralizing antibody b12 are disclosed, as in their use in making vaccines for preventing or treating HIV.
    Type: Application
    Filed: March 8, 2006
    Publication date: January 4, 2007
    Applicant: RAMOT AT TEL AVIV UNIVERSITY
    Inventors: Jonathan Gershoni, Erez Bublil, Dimitri Denisov, Galina Denisova
  • Mapping and reconstitution of a conformational discontinuous binding surface
    Patent number: RE44747
    Abstract: The structure of conformational, discontinuous binding surfaces that associate with a binding molecule, preferably the epitopes of monoclonal antibodies (mAbs) may be discovered. The binding molecule is used to select specific peptides from a peptide library that, in turn, are used as a binding surface (epitope) defining database that is applied via a novel computer algorithm to analyze the crystalline-structure of the original binding surface (antigen). An antigenic epitope-mimetic that is recognized by its original mAb may be reconstituted based on the segments of the epitope identified in the prediction. The basic elements of the binding domain on gp120 that is recognized by broadly neutralizing antibody b12 are disclosed, as in their use in making vaccines for preventing or treating HIV.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: February 4, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Jonathan Gershoni, Erez Moshe Bublil, Dimitri Denisov, Galina Denisova