Patents by Inventor Dimitri Govorko

Dimitri Govorko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Single chain antibody against mutant p53
    Patent number: 7288637
    Abstract: More than 90% of mutations found in the p53 protein produce a conformational change in p53 which results in the exposure of an epitope, which is otherwise hidden in the hydrophobic core of the molecule. A single chain antibody (scFv) which specifically recognizes this common mutant epitope in mutant p53 but not in wild type p53 is disclosed. Also described are a DNA molecule encoding the scFv, pharmaceutical compositions comprising the antibody and methods of treatment using the pharmaceutical compositions.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: October 30, 2007
    Assignee: Ramot At Tel Aviv University Ltd.
    Inventors: Beka Solomon, Gerald Cohen, Dimitri Govorko
  • Single chain antibody against mutant p53
    Patent number: 6630584
    Abstract: More than 90% of mutations found in the p53 protein produce a conformational change in p53 which results in the exposure of an epitope, which is otherwise hidden in the hydrophobic core of the molecule. A single chain antibody (scFv) which specifically recognizes this common mutant epitope in mutant p53 but not in wild type p53 is disclosed. Also described are a DNA molecule encoding the scFv, pharmaceutical compositions comprising the antibody and methods of treatment using the pharmaceutical compositions.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: October 7, 2003
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Beka Solomon, Gerald Cohen, Dimitri Govorko
  • Single chain antibody against mutant P53
    Publication number: 20030022244
    Abstract: More than 90% of mutations found in the p53 protein produce a conformational change in p53 which results in the exposure of an epitope, which is otherwise hidden in the hydrophobic core of the molecule. A single chain antibody (scFv) which specifically recognizes this common mutant epitope in mutant p53 but not in wild type p53 is disclosed. Also described are a DNA molecule encoding the scFv, pharmaceutical compositions comprising the antibody and methods of treatment using the pharmaceutical compositions.
    Type: Application
    Filed: September 20, 2002
    Publication date: January 30, 2003
    Applicant: RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD.
    Inventors: Beka Solomon, Gerald Cohen, Dimitri Govorko