Patents by Inventor Dimitrios Georgakopoulos
Dimitrios Georgakopoulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230355170Abstract: Devices, systems and methods for non-invasive modulation of the baroreflex system of a patient. In embodiments, the present disclosure may be used to measure and monitor baroreflex function for diagnostic purposes in patients acutely or chronically to inform and guide medical treatment, assess disease severity, or assess morbidity/mortality risk. In embodiments, the present disclosure may be used to provide non-invasive baroreflex activation therapy acutely or chronically to treat a variety of disease conditions through rebalancing of the sympathetic and parasympathetic limbs of the autonomic nervous system and their connections to higher brain centers.Type: ApplicationFiled: February 27, 2023Publication date: November 9, 2023Inventors: Dimitrios Georgakopoulos, Ivana Stojanovic, Nadim Yared
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Publication number: 20210205621Abstract: A method for stimulating nerve fibers to treat a condition in a patient first involves identifying carotid sinus nerve afferent fibers in a first side of the patient's neck and identifying cardiac-specific vagal nerve afferent fibers in the first side of the patient's neck. The method further involves placing a first multipolar electrode device around the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers. Finally, the method involves stimulating the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers, using the first multipolar electrode device. This method may be performed on a second side of the neck as well.Type: ApplicationFiled: January 25, 2021Publication date: July 8, 2021Inventors: Dimitrios Georgakopoulos, Molly Wade
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Patent number: 10918865Abstract: A method for stimulating nerve fibers to treat a condition in a patient first involves identifying carotid sinus nerve afferent fibers in a first side of the patient's neck and identifying cardiac-specific vagal nerve afferent fibers in the first side of the patient's neck. The method further involves placing a first multipolar electrode device around the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers. Finally, the method involves stimulating the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers, using the first multipolar electrode device. This method may be performed on a second side of the neck as well.Type: GrantFiled: April 24, 2019Date of Patent: February 16, 2021Assignee: BAROLOGICS, INC.Inventors: Dimitrios Georgakopoulos, Molly Wade
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Publication number: 20190329037Abstract: A method for stimulating nerve fibers to treat a condition in a patient first involves identifying carotid sinus nerve afferent fibers in a first side of the patient's neck and identifying cardiac-specific vagal nerve afferent fibers in the first side of the patient's neck. The method further involves placing a first multipolar electrode device around the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers. Finally, the method involves stimulating the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers, using the first multipolar electrode device. This method may be performed on a second side of the neck as well.Type: ApplicationFiled: April 24, 2019Publication date: October 31, 2019Inventors: Dimitrios Georgakopoulos, Molly Wade
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Publication number: 20160263301Abstract: Systems, methods, and devices for treating pulmonary arterial hypertension are provided. The system comprises an implantable actuator that compresses the pulmonary artery.Type: ApplicationFiled: March 9, 2016Publication date: September 15, 2016Inventors: David Rosa, Dimitrios Georgakopoulos, Martin C. Cook, Tolga Tas
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Patent number: 8948874Abstract: Devices and methods of use are described for identification, treatment, and/or management of heart failure and/or associated conditions. An exemplary device may include a first fluid status monitoring circuit configured to monitor a first fluid status indicator of a pulmonary fluid status associated with pulmonary edema, a second fluid status monitoring circuit configured to monitor a separate and different second fluid status indicator of a non-pulmonary fluid status, and a controller coupled to the first and second fluid status monitoring circuits, and a therapy circuit coupled to the controller. The controller is configured to use information about the first and second fluid status indicators to determine a therapy control signal to control a therapy, and the therapy circuit is configured to provide therapy in response to the therapy control signal to adjust at least one of the pulmonary fluid status or the non-pulmonary fluid status.Type: GrantFiled: December 27, 2013Date of Patent: February 3, 2015Assignee: CVRx, Inc.Inventors: Dimitrios Georgakopoulos, Eric Grant Lovett
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Publication number: 20140163649Abstract: Devices and methods of use are described for identification, treatment, and/or management of heart failure and/or associated conditions. An exemplary device may include a first fluid status monitoring circuit configured to monitor a first fluid status indicator of a pulmonary fluid status associated with pulmonary edema, a second fluid status monitoring circuit configured to monitor a separate and different second fluid status indicator of a non-pulmonary fluid status, and a controller coupled to the first and second fluid status monitoring circuits, and a therapy circuit coupled to the controller. The controller is configured to use information about the first and second fluid status indicators to determine a therapy control signal to control a therapy, and the therapy circuit is configured to provide therapy in response to the therapy control signal to adjust at least one of the pulmonary fluid status or the non-pulmonary fluid status.Type: ApplicationFiled: December 27, 2013Publication date: June 12, 2014Applicant: CVRx, Inc.Inventors: Dimitrios Georgakopoulos, Eric Grant Lovett
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Patent number: 8744586Abstract: Devices and methods for use of identification, treatment and/or management of heart failure and/or associated conditions. Methods may include providing a baroreflex therapy system, providing an implantable measurement device proximate a blood vessel of a patient, the implantable measurement device including a plurality of electrodes, determining an impedance of the blood vessel with the implantable measurement device over a time period of at least one cardiac cycle, generating at least one signal representative of a pressure waveform based on the impedance, activating, deactivating or otherwise modulating the baroreflex therapy system to deliver a therapy to treat heart failure based at least in part on the at least one signal representative of the pressure waveform.Type: GrantFiled: November 30, 2012Date of Patent: June 3, 2014Assignee: CVRx, Inc.Inventors: Dimitrios Georgakopoulos, Eric Grant Lovett, Nadim Yared
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Patent number: 8700162Abstract: Devices and methods of use for identification, treatment and/or management of heart failure and/or associated conditions. An exemplary device may include a first sensor configured to monitor a parameter indicative of a fluid level in a pulmonary circulation of a patient, a second sensor configured to monitor a parameter indicative of a fluid level in a non-pulmonary circulation of a patient, and a control system coupled to the first sensor and second sensor. The control system is configured to provide a baroreflex therapy to the patient based at least in part on the parameter indicative of a fluid level in a pulmonary circulation and the parameter indicative of a fluid level in a non-pulmonary circulation. The baroreflex therapy adjusts at least one of the fluid level in the pulmonary circulation and the fluid level in the non-pulmonary circulation.Type: GrantFiled: October 8, 2012Date of Patent: April 15, 2014Assignee: CVRx, Inc.Inventors: Dimitrios Georgakopoulos, Eric Grant Lovett
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Publication number: 20130338735Abstract: Devices and methods of use for identification, treatment and/or management of heart failure and/or associated conditions. An exemplary device may include a first sensor configured to monitor a parameter indicative of a fluid level in a pulmonary circulation of a patient, a second sensor configured to monitor a parameter indicative of a fluid level in a non-pulmonary circulation of a patient, and a control system coupled to the first sensor and second sensor. The control system is configured to provide a baroreflex therapy to the patient based at least in part on the parameter indicative of a fluid level in a pulmonary circulation and the parameter indicative of a fluid level in a non-pulmonary circulation. The baroreflex therapy adjusts at least one of the fluid level in the pulmonary circulation and the fluid level in the non-pulmonary circulation.Type: ApplicationFiled: October 8, 2012Publication date: December 19, 2013Inventors: Dimitrios Georgakopoulos, Eric Grant Lovett
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Patent number: 8600511Abstract: Devices and methods of use are described for identification, treatment, and/or management of heart failure and/or associated conditions. An exemplary system may include a baroreflex activation device configured to be implantable proximate a blood vessel of a patient, a measurement device configured to be implantable proximate a blood vessel, and a control system coupled to the baroreflex activation device and the measurement device and in communication with a blood pressure sensing means. The control system is programmed to automatically determine pressure waveform data from the measurement device over a time period of at least a portion of one cardiac cycle, determine a patient physiological parameter based on the pressure waveform data, and compare the patient physiological parameter to a blood pressure measurement taken from the blood pressure sensing means.Type: GrantFiled: October 4, 2012Date of Patent: December 3, 2013Assignee: CVRx, Inc.Inventors: Nadim Yared, Dimitrios Georgakopoulos, Eric Grant Lovett
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Patent number: 8401652Abstract: Devices and methods of use are described for detecting and treating an undesirable level of fluid in a pulmonary circulation of a patient. An exemplary system may include an implantable baroreflex activation device including an electrode configured to be implanted proximate a baroreptor within a patient, an implantable sensor configured to provide an indication of a fluid level within the patient, and a control system coupled to the baroreflex activation device and the sensor. The control system may be programmed to automatically detect a level of a fluid in a pulmonary circulation of the patient with the sensor and upon detecting an undesirable level of the fluid in the pulmonary circulation, delivering a therapy via the electrode of the baroreflex activation device to reduce the level of fluid in the pulmonary circulation.Type: GrantFiled: January 27, 2012Date of Patent: March 19, 2013Assignee: CVRx, Inc.Inventors: Dimitrios Georgakopoulos, Eric Grant Lovett
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Patent number: 8321024Abstract: Devices and methods of use identification, treatment, and/or management of heart failure and/or associated conditions. Methods may include providing a baroreflex therapy system including a blood pressure sensor and a heart rate sensor, providing an implantable measurement device proximate a blood vessel of a patient, the implantable measurement device including an electrode, providing a control system coupled to the baroreflex therapy system and the implantable measurement device, the control system programmed to automatically determine an impedance of the blood vessel with the implantable measurement device over a time period of at least one cardiac cycle, determine arterial stiffness of the blood vessel based on the impedance, determine blood pressure and heart rate, and activate, deactivate or otherwise modulate the baroreflex therapy system to deliver a baroreflex therapy based on the blood pressure, heart rate and arterial stiffness.Type: GrantFiled: January 6, 2011Date of Patent: November 27, 2012Assignee: CVRx, Inc.Inventors: Dimitrios Georgakopoulos, Eric G. Lovett, Nadim Yared
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Publication number: 20100004714Abstract: Devices and methods of use identification, treatment, and/or management of heart failure and/or associated conditions. Methods may include providing a baroreflex therapy system, providing an implantable measurement device proximate a blood vessel of a patient, the implantable measurement device including a plurality of electrodes, determining an impedance of the blood vessel with the implantable measurement device over a time period of at least one cardiac cycle, generating at least one signal representative of a pressure waveform based on the impedance, activating, deactivating or otherwise modulating the baroreflex therapy system to deliver a therapy to treat heart failure based at least in part on the at least one signal representative of the pressure waveform.Type: ApplicationFiled: June 16, 2009Publication date: January 7, 2010Inventors: Dimitrios Georgakopoulos, Eric Grant Lovett, Adam Cates
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Publication number: 20020055849Abstract: A workflow management method and system including a process definition tool enabling a user to model a workflow process definition. A workflow management engine is configured to interpret the workflow process definition to perform workflow management tasks. The definition tool and workflow management engine are configured to support primitives including an inhibitor primitive that enables modeling processes having mutually exclusive interdependencies, an option primitive that may be instantiated zero or more times, a group assignment primitive that supports group activity, and an activity placeholder that enables the specification of activities whose concrete types may be unknown at process definition time.Type: ApplicationFiled: June 29, 2001Publication date: May 9, 2002Inventors: Dimitrios Georgakopoulos, Marek Rusinkiewicz, Hans Alois Schuster
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Patent number: 5241675Abstract: Our invention guarantees global serializability by preventing multidatabase transactions from being serialized in different ways at the participating local database systems (LDBS). In one embodiment tickets are used to inform the MDBS of the relative serialization order of the subtransactions of each global transactions at each LDBS. A ticket is a (logical) timestamp whose value is stored as a regular data item in each LDBS. Each substransaction of a global transaction is required to issue the take-a-ticket operations which consists of reading the value of the ticket (i.e., read ticket) and incrementing it (i.e., write (ticket+1)) through regular data manipulation operations. Only the subtransactions of global transactions take tickets. When different global transactions issue subtransactions at a local database, each subtransaction will include the take-a-ticket operations. Therefore, the ticket values associated with each global subtransaction at the MDBS reflect the local serialization order at each LDBS.Type: GrantFiled: April 9, 1992Date of Patent: August 31, 1993Assignee: Bell Communications Research, Inc.Inventors: Amit P. Sheth, Dimitrios Georgakopoulos, Marek E. Rusinkiewicz