Patents by Inventor Dimitrios Mathios

Dimitrios Mathios has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DETECTION OF LUNG CANCER USING CELL-FREE DNA FRAGMENTATION
    Publication number: 20240060141
    Abstract: Cell free DNA (cfDNA) fragmentation for lung cancer detection is combined with current imaging-based screening methods and biomarkers.
    Type: Application
    Filed: December 21, 2021
    Publication date: February 22, 2024
    Inventors: Victor Velculescu, Robert B. Scharpf, Dimitrios Mathios, Jillian A. Phallen, Daniel Bruhm, Stephen Cristiano
  • COMBINATION OF IMMUNOTHERAPY WITH LOCAL CHEMOTHERAPY FOR THE TREATMENT OF MALIGNANCIES
    Publication number: 20230414540
    Abstract: The presently disclosed subject matter provides methods, compositions, and kits for the treatment of cancer using a combination treatment comprising a locally administered chemotherapy and an immunotherapeutic agent. The presently disclosed subject matter also provides methods of promoting the combination treatment and instructing a patient to receive the combination treatment are also provided, as well immunotherapeutic, non-immunosuppressive compositions comprising the combination treatment, and methods of using the immunotherapeutic, non-immunosuppressive compositions for treating cancer.
    Type: Application
    Filed: September 1, 2023
    Publication date: December 28, 2023
    Inventors: DIMITRIOS MATHIOS, BETTY TYLER, DREW PARDOLL, HENRY BREM, MICHAEL LIM
  • Combination of immunotherapy with local chemotherapy for the treatment of malignancies
    Patent number: 11779555
    Abstract: The presently disclosed subject matter provides methods, compositions, and kits for the treatment of cancer using a combination treatment comprising a locally administered chemotherapy and an immunotherapeutic agent. The presently disclosed subject matter also provides methods of promoting the combination treatment and instructing a patient to receive the combination treatment are also provided, as well immunotherapeutic, non-immunosuppressive compositions comprising the combination treatment, and methods of using the immunotherapeutic, non-immunosuppressive compositions for treating cancer.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: October 10, 2023
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Dimitrios Mathios, Betty Tyler, Drew Pardoll, Henry Brem, Michael Lim
  • COMBINATION OF IMMUNOTHERAPY WITH LOCAL CHEMOTHERAPY FOR THE TREATMENT OF MALIGNANCIES
    Publication number: 20210077434
    Abstract: The presently disclosed subject matter provides methods, compositions, and kits for the treatment of cancer using a combination treatment comprising a locally administered chemotherapy and an immunotherapeutic agent. The presently disclosed subject matter also provides methods of promoting the combination treatment and instructing a patient to receive the combination treatment are also provided, as well immunotherapeutic, non-immunosuppressive compositions comprising the combination treatment, and methods of using the immunotherapeutic, non-immunosuppressive compositions for treating cancer.
    Type: Application
    Filed: November 13, 2020
    Publication date: March 18, 2021
    Inventors: DIMITRIOS MATHIOS, BETTY TYLER, DREW PARDOLL, HENRY BREM, MICHAEL LIM
  • Combination of immunotherapy with local chemotherapy for the treatment of malignancies
    Patent number: 10864180
    Abstract: The presently disclosed subject matter provides methods, compositions, and kits for the treatment of cancer using a combination treatment comprising a locally administered chemotherapy and an immunotherapeutic agent. The presently disclosed subject matter also provides methods of promoting the combination treatment and instructing a patient to receive the combination treatment are also provided, as well immunotherapeutic, non-immunosuppressive compositions comprising the combination treatment, and methods of using the immunotherapeutic, non-immunosuppressive compositions for treating cancer.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: December 15, 2020
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Dimitrios Mathios, Betty Tyler, Drew Pardoll, Henry Brem, Michael Lim
  • Use of the ZMIZ1 marker in directing treatment and predicting survival in cancer
    Patent number: 10174384
    Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions for treating cancer and predicting patient survival. In one embodiment, a method comprises (a) obtaining a biological sample from the patient; and (b) detecting hypermethylation of ZMIZ1 using primers that specifically bind to CpG island 139 at the alternative promoter of the ZMIZ1 gene.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: January 8, 2019
    Assignee: The Johns Hopkins University
    Inventors: Dimitrios Mathios, Michael Lim, Patrick Ha, Chetan Bettegowda, Taeyoung Hwang, Chul-Kee Park
  • COMBINATION OF IMMUNOTHERAPY WITH LOCAL CHEMOTHERAPY FOR THE TREATMENT OF MALIGNANCIES
    Publication number: 20160310453
    Abstract: The presently disclosed subject matter provides methods, compositions, and kits for the treatment of cancer using a combination treatment comprising a locally administered chemotherapy and an immunotherapeutic agent. The presently disclosed subject matter also provides methods of promoting the combination treatment and instructing a patient to receive the combination treatment are also provided, as well immunotherapeutic, non-immunosuppressive compositions comprising the combination treatment, and methods of using the immunotherapeutic, non-immunosuppressive compositions for treating cancer.
    Type: Application
    Filed: April 22, 2016
    Publication date: October 27, 2016
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: DIMITRIOS MATHIOS, BETTY TYLER, DREW PARDOLL, HENRY BREM, MICHAEL LIM
  • USE OF THE ZMIZ1 MARKER IN DIRECTING TREATMENT AND PREDICTING SURVIVAL IN CANCER
    Publication number: 20160273050
    Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions for treating cancer and predicting patient survival. In one embodiment, a method comprises (a) obtaining a biological sample from the patient; and (b) detecting hypermethylation of ZMIZ1 using primers that specifically bind to CpG island 139 at the alternative promoter of the ZMIZ1 gene.
    Type: Application
    Filed: March 16, 2016
    Publication date: September 22, 2016
    Inventors: Dimitrios Mathios, Michael Lim, Patrick Ha, Chetan Bettegowda, Taeyoung Hwang, Chul-Kee Park