Patents by Inventor Dimitrios Sakellariou
Dimitrios Sakellariou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160116554Abstract: A probe for nuclear magnetic resonance includes at least one radiofrequency coil (BRF3). The radiofrequency coil includes a first helical winding (E1??) having turns (S) that are tilted by an angle other than zero and 90° relative to an axis (z) and a second helical winding (E2??), which is coaxial to the first winding, having turns that are tilted by an angle -a relative to the axis. The helical windings preferably have a length-to-diameter ratio of 1 to 10 and 1 to 25 turns. An apparatus for nuclear magnetic resonance includes the probe. A method for generating a radiofrequency magnetic field uses the radiofrequency coil.Type: ApplicationFiled: March 26, 2014Publication date: April 28, 2016Inventors: Dimitrios SAKELLARIOU, Javier ALONSO
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Patent number: 9128167Abstract: The cylindrical permanent magnet device includes at least one basic structure (10) having a longitudinal axis (z) and a set (20) of coaxial magnetized structures (21, 22, 23, 24) that are in the form of non-contiguous rings of axis that is the longitudinal axis (z) and that are disposed on the same side of the basic structure (10), defining an exterior surface perpendicular to the longitudinal axis (z) to produce a magnetic field (B0) outside the magnet device in an exterior area of interest (3) situated at a predetermined distance from the exterior surface along the longitudinal axis (z). At least one of the coaxial magnetized structures (21, 22, 23, 24) in the form of rings is divided into components in the form of non-contiguous identical sectors.Type: GrantFiled: August 27, 2010Date of Patent: September 8, 2015Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Dimitrios Sakellariou, Guy Aubert, Cédric Hugon
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Patent number: 8860539Abstract: A magnetized structure that induces in a central area of interest a homogeneous magnetic field of predetermined orientation relative to a longitudinal axis (z) of the structure comprises at least two magnetized rings (110, 120) disposed symmetrically relative to a plane (P) that is perpendicular to the longitudinal axis (z) and that contains the central area of interest, and at least one median annular magnetized structure disposed at least partly between the two magnetized rings (110, 120) and also disposed symmetrically relative to the plane (P) of symmetry, one of the two magnetized rings (110) being magnetized radially relative to the longitudinal axis (z) with divergent magnetization and the other of the two magnetized rings (120) being magnetized radially relative to the longitudinal axis (z) with convergent magnetization, and the median annular magnetized structure being magnetized with an orientation different from that of the magnetization of the two magnetized rings (110, 120).Type: GrantFiled: August 27, 2010Date of Patent: October 14, 2014Assignee: Commissariat a l'Energie Atomique et aux Energies AlternativesInventors: Dimitrios Sakellariou, Cédric Hugon, Guy Aubert
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Patent number: 8773230Abstract: The magnetized structure that induces in a central area of interest a homogeneous magnetic field oriented along a longitudinal axis (z) of the structure comprises first and second magnetized rings (111, 121) disposed symmetrically relative to a plane (P) that is perpendicular to said longitudinal axis (z) and that contains said central area of interest, and one median annular magnetized structure (330) disposed between the first and second magnetized rings (111, 121) and also disposed symmetrically relative to the plane (P) of symmetry. The first magnetized ring (111) is magnetized radially relative to the longitudinal axis (z) with divergent magnetization, the second magnetized ring (121) is magnetized radially relative to the longitudinal axis (z) with convergent magnetization, and the median annular magnetized structure (330) is magnetized along the longitudinal axis (z).Type: GrantFiled: August 27, 2010Date of Patent: July 8, 2014Assignee: Commissariat a l'Energie Atomique et aux Energies AlternativesInventors: Dimitrios Sakellariou, Cédric Hugon, Guy Aubert
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Publication number: 20120098630Abstract: A cylindrical permanent magnet device that induces in a central area of interest a homogeneous magnetic field of predetermined orientation relative to a longitudinal axis (z) of the device comprises first and second annular magnetized structures (111, 121) disposed symmetrically relative to a plane (P) that is perpendicular to the longitudinal axis (z) and contains the central area of interest, and a third annular magnetized structure (112, 122) disposed between the first and second structures (111, 121) and also disposed symmetrically relative to the plane (P) of symmetry. The first, second, and third annular magnetized structures (111, 121, 112, 122) are divided into components in the form of sectors.Type: ApplicationFiled: August 27, 2010Publication date: April 26, 2012Inventors: Dimitrios Sakellariou, Cédric Hugon, Guy Aubert
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Publication number: 20120098539Abstract: The cylindrical permanent magnet device includes at least one basic structure (10) having a longitudinal axis (z) and a set (20) of coaxial magnetized structures (21, 22, 23, 24) that are in the form of non-contiguous rings of axis that is the longitudinal axis (z) and that are disposed on the same side of the basic structure (10), defining an exterior surface perpendicular to the longitudinal axis (z) to produce a magnetic field (B0) outside the magnet device in an exterior area of interest (3) situated at a predetermined distance from the exterior surface along the longitudinal axis (z). At least one of the coaxial magnetized structures (21, 22, 23, 24) in the form of rings is divided into components in the form of non-contiguous identical sectors.Type: ApplicationFiled: August 27, 2010Publication date: April 26, 2012Inventors: Dimitrios Sakellariou, Guy Aubert, Cédric Hugon
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Patent number: 8106657Abstract: The present invention concerns an apparatus (1?) for NMR spectroscopy and/or NMR imaging of a sample. The apparatus comprises a static probe comprising an outer coil for excitation of nuclei of the sample by generating an incident radio frequency field at the Larmor frequency of the nuclei, and for reception of a return radio frequency field emitted by the sample, and a sensitive inner coil (6a?) which is mounted closely around or in contact with the sample container and which is wirelessly coupled to the outer coil by an electromagnetic radio frequency field. The sensitive inner coil is embedded in an inner spinning rotor (2) which is rotatively mounted inside the static probe and which is integral with the sample container, so that the filling factor and the radio frequency field amplitude in the sensitive coil are maximized.Type: GrantFiled: July 5, 2006Date of Patent: January 31, 2012Assignee: Commissariat a l'Energie AtomiqueInventors: Dimitrios Sakellariou, Jacques-François Jacquinot
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Publication number: 20120013338Abstract: A magnetized structure that induces in a central area of interest a homogeneous magnetic field of predetermined orientation relative to a longitudinal axis (z) of the structure comprises at least two magnetized rings (110, 120) disposed symmetrically relative to a plane (P) that is perpendicular to the longitudinal axis (z) and that contains the central area of interest, and at least one median annular magnetized structure disposed at least partly between the two magnetized rings (110, 120) and also disposed symmetrically relative to the plane (P) of symmetry, one of the two magnetized rings (110) being magnetized radially relative to the longitudinal axis (z) with divergent magnetization and the other of the two magnetized rings (120) being magnetized radially relative to the longitudinal axis (z) with convergent magnetization, and the median annular magnetized structure being magnetized with an orientation different from that of the magnetization of the two magnetized rings (110, 120).Type: ApplicationFiled: August 27, 2010Publication date: January 19, 2012Inventors: Dimitrios Sakellariou, Cédric Hugon, Guy Aubert
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Publication number: 20110291781Abstract: The magnetized structure that induces in a central area of interest a homogeneous magnetic field oriented along a longitudinal axis (z) of the structure comprises first and second magnetized rings (111, 121) disposed symmetrically relative to a plane (P) that is perpendicular to said longitudinal axis (z) and that contains said central area of interest, and one median annular magnetized structure (330) disposed between the first and second magnetized rings (111, 121) and also disposed symmetrically relative to the plane (P) of symmetry. The first magnetized ring (111) is magnetized radially relative to the longitudinal axis (z) with divergent magnetization, the second magnetized ring (121) is magnetized radially relative to the longitudinal axis (z) with convergent magnetization, and the median annular magnetized structure (330) is magnetized along the longitudinal axis (z).Type: ApplicationFiled: August 27, 2010Publication date: December 1, 2011Inventors: Dimitrios Sakellariou, Cédric Hugon, Guy Aubert
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Patent number: 7750633Abstract: A method and system of magnetic resonance imaging does not need a large homogenous field to truncate a gradient field. Spatial information is encoded into the spin magnetization by allowing the magnetization to evolve in a non-truncated gradient field and inducing a set of 180 degree rotations prior to signal acquisition.Type: GrantFiled: July 21, 2005Date of Patent: July 6, 2010Assignee: The Regents of the University of CaliforniaInventors: Alexander Pines, Dimitrios Sakellariou, Carlos A. Meriles, Andreas H. Trabesinger
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Publication number: 20100156414Abstract: The present invention concerns an apparatus (1?) for NMR spectroscopy and/or NMR imaging of a sample. The apparatus comprises a static probe comprising an outer coil for excitation of nuclei of said sample by generating an incident radio frequency field at the Larmor frequency of said nuclei, and for reception of a return radio frequency field emitted by said sample, and a sensitive inner coil (6a?) which is mounted closely around or in contact with the sample container and which is wirelessly coupled to said outer coil by an electromagnetic radio frequency field. The sensitive inner coil is embedded in an inner spinning rotor (2) which is rotatively mounted inside said static probe and which is integral with said sample container, so that the filling factor and the radio frequency field amplitude in said sensitive coil are maximized.Type: ApplicationFiled: July 5, 2006Publication date: June 24, 2010Inventors: Dimitrios Sakellariou, Jacques-Francois Jacquinot
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Publication number: 20090261826Abstract: A method and system of magnetic resonance imaging does not need a large homogenous field to truncate a gradient field. Spatial information is encoded into the spin magnetization by allowing the magnetization to evolve in a non-truncated gradient field and inducing a set of 180 degree rotations prior to signal acquisition.Type: ApplicationFiled: July 21, 2005Publication date: October 22, 2009Inventors: Alexander Pines, Dimitrios Sakellariou, Carlos A. Meriles, Andreas H. Trabesinger
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Patent number: 7439738Abstract: Methods and systems for compensating for static magnetic field inhomogeneities during nuclear magnetic resonance detection are disclosed. Application of radio frequency pulses and/or magnetic field gradients may be used to correct for spin dephasing caused by the inhomogeneities. The methods and system may be used to improve signal-to-noise ratios in NMR and MRI systems where magnetic field inhomogeneity may have an effect.Type: GrantFiled: January 19, 2007Date of Patent: October 21, 2008Assignee: The Regents of The University of CaliforniaInventors: Alexander Pines, Daniel Topgaard, Dimitrios Sakellariou, Rachel W. Martin, Carlos A. Meriles
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Publication number: 20070194788Abstract: Methods and systems for compensating for static magnetic field inhomogeneities during nuclear magnetic resonance detection are disclosed. Application of radio frequency pulses and/or magnetic field gradients may be used to correct for spin dephasing caused by the inhomogeneities. The methods and system may be used to improve signal-to-noise ratios in NMR and MRI systems where magnetic field inhomogeneity may have an effect.Type: ApplicationFiled: January 19, 2007Publication date: August 23, 2007Inventors: Alexander Pines, Daniel Topgaard, Dimitrios Sakellariou, Rachel Martin, Carlos Meriles
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Patent number: 6674282Abstract: A method and apparatus for ex-situ nuclear magnetic resonance spectroscopy for use on samples outside the physical limits of the magnets in inhomogeneous static and radio-frequency fields. Chemical shift spectra can be resolved with the method using sequences of correlated, composite z-rotation pulses in the presence of spatially matched static and radio frequency field gradients producing nutation echoes. The amplitude of the echoes is modulated by the chemical shift interaction and an inhomogeneity free FID may be recovered by stroboscopically sampling the maxima of the echoes. In an alternative embodiment, full-passage adiabatic pulses are consecutively applied. One embodiment of the apparatus generates a static magnetic field that has a variable saddle point.Type: GrantFiled: August 13, 2002Date of Patent: January 6, 2004Assignee: The Regents of the University of CaliforniaInventors: Alexander Pines, Carlos A. Meriles, Henrike Heise, Dimitrios Sakellariou, Adam Moule
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Publication number: 20030052677Abstract: A method and apparatus for ex-situ nuclear magnetic resonance spectroscopy for use on samples outside the physical limits of the magnets in inhomogeneous static and radio-frequency fields. Chemical shift spectra can be resolved with the method using sequences of correlated, composite z-rotation pulses in the presence of spatially matched static and radio frequency field gradients producing nutation echoes. The amplitude of the echoes is modulated by the chemical shift interaction and an inhomogeneity free FID may be recovered by stroboscopically sampling the maxima of the echoes. In an alternative embodiment, full-passage adiabatic pulses are consecutively applied. One embodiment of the apparatus generates a static magnetic field that has a variable saddle point.Type: ApplicationFiled: August 13, 2002Publication date: March 20, 2003Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Alexander Pines, Carlos A. Meriles, Henrike Heise, Dimitrios Sakellariou, Adam Moule
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Method to improve resolution of two-dimensional heteronuclear correlation spectra in solid-state NMR
Patent number: 6184683Abstract: A new two-dimensional NMR carbon-proton chemical shift correlation experiment, the MAS-J-HMQC experiment, is proposed for rotating solids. The magnetization transfer used to obtain the correlations is based on scalar heteronuclear J couplings. The 2D map provides through-bond chemical shift correlations between directly bonded proton carbon pairs in a similar way to corresponding high-resolution liquid state experiments. The transfer through J coupling is shown to be efficient and more selective that those based on heteronuclear dipolar couplings. The experiment, which works at high MAS spinning rates, yields the unambiguous assignment of the proton resonances. The experiment is demonstrated on several organic compounds.Type: GrantFiled: July 8, 1999Date of Patent: February 6, 2001Assignee: Bruker Analytik GmbHInventors: Lyndon Emsley, Dimitrios Sakellariou, Anne Lesage, Stefan Steuernagel