Patents by Inventor Dimitrios Vlaxakos

Dimitrios Vlaxakos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,(3,)5-substituted imidazoles, their use in the treatment of hypertension and methods for their preparation
    Patent number: 8563586
    Abstract: The present invention provides novel 1,5 and 1,3,5-substituted imidazole compounds in hydrophilic or lipophilic form, which are useful as angiotensin II ATI receptor antagonists suitable for transdermal delivery. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing compounds and their use in methods of treating hypertension and cardiovascular diseases.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: October 22, 2013
    Assignee: Eldrug S.A.
    Inventors: John Matsoukas, Michael Maragoudakis, Dimitrios Vlaxakos
  • 1,3 AND 1,3,5 SUBSTITUTED IMIDAZOLES AS ANTIHYPERTENSIVES
    Publication number: 20100216854
    Abstract: The present invention provides novel 1,5 and 1,3,5-substituted imidazole compounds of formulas (I), (IIa), (IIIb) in hydrophilic or lipophilic form, which are useful as angiotensin II AT1 receptor antagonists with sympathetic suppressant properties. In particular, the invention provides pharmaceutical compositions containing the pharmacophoric groups of Losartan and Clonidine as well compounds, processes and intermediates for preparing compounds and their use in methods of treating hypertension and cardiovascular diseases through Renin Angiotensin System (RAS) and Sympathetic System (SS). Alkylated histamine based double action Saltans are lipophilic and can act transdermally.
    Type: Application
    Filed: July 25, 2008
    Publication date: August 26, 2010
    Applicant: Eldrug S.A.
    Inventors: John Matsoukas, Charalambos Gavras, Dimitrios Vlaxakos, Michael Maragoudakis