Patents by Inventor Dimitris Kioussis

Dimitris Kioussis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Locus control subregions conferring integration-site independent transgene expression abstract of the disclosure
    Patent number: 6110666
    Abstract: The invention encompasses a locus control subregion that possesses chromatin opening domain activity, the activity conferring reproducible activation of tissue-specific expression on a linked transgene to a non-physiological level when the transgene is integrated in single copy in the genome of a host cell.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 29, 2000
    Assignee: Medical Research Council
    Inventors: Franklin Gerardus Grosveld, James Ellis, Dimitris Kioussis
  • Transgenic mice expressing TSSV40 large T antigen
    Patent number: 5866759
    Abstract: The provision of cell lines from virtually any cell type of the animal body is greatly facilitated by transgenic non-human eukaryotic animals of the invention in which at least some cells have (i) a differentiation inhibiting sequence chromosomally incorporated under the control of a non-constitutive promotor and/or (ii) a differentiation inhibiting sequence which is itself conditionally active. Said genes are chromosomally incorporated under the control of a promotor such that expression of said sequence is normally held below an effective level, thus allowing normal cell development. However, cells taken from said animal may be prevented from completing differentiation to a non-dividing state in tissue culture by activating expression of said sequence.
    Type: Grant
    Filed: July 2, 1997
    Date of Patent: February 2, 1999
    Assignee: Ludwig Institute For Cancer Research
    Inventors: Parmjit Singh Jat, Dimitris Kioussis, Mark David Noble
  • Vector for integration site independent gene expression in mammalian host cells
    Patent number: 5849997
    Abstract: Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type restricted, integration site independent, copy number dependent expression of the gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 15, 1998
    Assignee: Medical Research Council Ltd.
    Inventors: Franklin Grosveld, Dimitris Kioussis
  • Vector for integration site independent gene expression in mammalian host cells
    Patent number: 5770398
    Abstract: Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type restricted, integration site independent, copy number dependent expression of the gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 23, 1998
    Assignee: Medical Research Council
    Inventors: Franklin Grosveld, Dimitris Kioussis
  • Methods for obtaining production of a gene product in a host cell in vivo or in vitro using a DNA molecule for integration site independent gene expression
    Patent number: 5744456
    Abstract: Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type restricted, integration site independent, copy number dependent expression of the gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 28, 1998
    Assignee: Medical Research Council
    Inventors: Franklin Grosveld, Dimitris Kioussis
  • Isolated DNA molecules for integration site independent gene expression in mammalian host cells
    Patent number: 5736359
    Abstract: Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type restricted, integration site independent, copy number dependent expression of the gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 7, 1998
    Assignee: Medical Research Council
    Inventors: Franklin Grosveld, Dimitris Kioussis
  • Transgenic mouse cells expressing ts SV40 large T
    Patent number: 5688692
    Abstract: The provision of cell lines from virtually any cell type of the animal body is greatly facilitated by transgenic non-human eukaryotic animals of the invention in which at least some cells have (i) a differentiation inhibiting sequence chromosomally incorporated under the control of a non-constitutive promotor and/or (ii) a differentiation inhibiting sequence which is itself conditionally active. Said genes are chromosomally incorporated under the control of a promotor such that expression of said sequence is normally held below an effective level, thus allowing normal cell development. However, cells taken from said animal may be prevented from completing differentiation to a non-dividing state in tissue culture by activating expression of said sequence.
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: November 18, 1997
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Parmjit Singh Jat, Dimitris Kioussis, Mark David Noble
  • Methods of obtaining a DNA sequence for integration site independent gene expression
    Patent number: 5635355
    Abstract: Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type restricted, integration site independent, copy number dependent expression of the gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 3, 1997
    Assignee: The Medical Research Council
    Inventors: Franklin Grosveld, Dimitris Kioussis
  • Isolated DNA molecules for intergration site independent gene expression in mammalian host cells
    Patent number: 5532143
    Abstract: Vectors for the integration of a gene into genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant ectivator sequence capable of eliciting host cell-type restricted, integration site independent, copy number dependent expression of the gene.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: July 2, 1996
    Assignee: The Medical Research Council
    Inventors: Franklin G. Grosveld, Dimitris Kioussis