Patents by Inventor Dimitris Skalkos

Dimitris Skalkos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imines of porphyrins, of porphyrin derivatives, and of related compounds, and pharmaceutical compositions containing such imines
    Patent number: 5744598
    Abstract: Purified imines of porphyrins, chlorins, bateriochlorins, chlorophylls, bacteriochlorophylls, purpurins, reduced purpurins, verdins, Diels Alder adducts, benzochlorins and metal complexes of the foregoing imines are disclosed. The formulas of the benzochlorinimines and of the benzochlorinimine metal complexes are set forth below: ##STR1## In specific examples, M in the metal complexes is a copper cation that is complexed with two of the nitrogens of the benzochlorinimine R' and R"" are methyl, and R1 through R8 are ethyl.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: April 28, 1998
    Assignees: University of Toledo, Medical College of Ohio
    Inventors: Dimitris Skalkos, Steven H. Selman, James A. Hampton, Alan R. Morgan
  • Method of treating cancer tumors with imine porphyrin compounds
    Patent number: 5512559
    Abstract: Purified imines of porphyrins, chlorins, bateriochlorins, chlorophylls, bacteriochlorophylls, purpurins, reduced purpurins, verdins, Diels Alder adducts, benzochlorins and metal complexes of the foregoing imines are disclosed. The formulas of the benzochlorinimines and of the benzochlorinimine metal complexes are set forth below: ##STR1## In specific examples, M in the metal complexes is a copper cation that is complexed with two of the nitrogens of the benzochlorinimine R' and R"" are methyl, and R1 through R8 are ethyl.
    Type: Grant
    Filed: January 19, 1995
    Date of Patent: April 30, 1996
    Assignee: The University of Toledo and Medical College of Ohio
    Inventors: Dimitris Skalkos, Steven H. Selman, James A. Hampton
  • Production and use of imines of porphyrins, of porphyrin derivatives and of related compounds, and of compositions containing such imines
    Patent number: 5424305
    Abstract: Purified imines of porphyrins, chlorins, bateriochlorins, chlorophylls, bacteriochlorophylls, purpurins, reduced purpurins, verdins, Diels Alder adducts, benzochlorins and metal complexes of the foregoing imines are disclosed for retarding growth of cancer tumors such as bladder tumors. The formulas of the benzochlorinimines and of the benzochlorinimine metal complexes are set forth below: ##STR1## In specific examples, M in the metal complexes is a copper cation that is complexed with two of the nitrogens of the benzochlorinimine R' and R"" are methyl, and R1 through R8 are ethyl.
    Type: Grant
    Filed: November 24, 1993
    Date of Patent: June 13, 1995
    Assignees: The University of Toledo, Medical College of Ohio
    Inventors: Dimitris Skalkos, Steven H. Selman, James A. Hampton