Abstract: The present invention provides an engineered clostridial toxin comprising at least one amino acid modification, wherein said at least one amino acid modification increases the isoelectric point (pI) of the engineered clostridial toxin to a value that is at least 0.2 pI units higher than the pI of an otherwise identical clostridial toxin lacking said at least one amino acid modification. Also provided are corresponding uses of the engineered clostridial toxin in therapy.

Abstract: Systems and methods for enrichment of data associated with risk prediction. Data may be enriched by incorporating one or more aspects of consumer credit, collateralized debt, mortgage, real property, and loan data for use in systems, products, and methods relying on risk prediction models to maximize the effectiveness of the risk prediction. A time-series of consumer credit data may be provided to provide historical context to data. In a particular application, enriched data is leveraged to predict occurrence of an event relating to underlying assets of a structured security, such as a mortgage-backed security. Other systems and methods are disclosed.