Patents by Inventor Dina Ron

Dina Ron has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human Sef isoforms and methods of using same for cancer diagnosis and gene therapy
    Patent number: 8354228
    Abstract: A method and pharmaceutical compositions useful for inhibiting the growth of solid tumors are provided. Specifically, the method is effected by administering to a subject in need thereof an agent capable of upregulating the expression level and/or activity of at least a functional portion of Sef, wherein the functional portion being capable of inhibiting RTK-mediated cell proliferation. Also provided are methods and kits for diagnosing and staging of cancer by detecting the expression level of hSef in a tissue sample, wherein a decrease in hSef expression level is indicative of cancer.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: January 15, 2013
    Assignee: Technion Research & Development Foundation Ltd.
    Inventor: Dina Ron
  • Human Sef isoforms and methods of using same for cancer diagnosis and gene therapy
    Publication number: 20100093840
    Abstract: A method and pharmaceutical compositions useful for inhibiting the growth of solid tumors are provided. Specifically, the method is effected by administering to a subject in need thereof an agent capable of upregulating the expression level and/or activity of at least a functional portion of Sef, wherein the functional portion being capable of inhibiting RTK-mediated cell proliferation. Also provided are methods and kits for diagnosing and staging of cancer by detecting the expression level of hSef in a tissue sample, wherein a decrease in hSef expression level is indicative of cancer.
    Type: Application
    Filed: December 7, 2009
    Publication date: April 15, 2010
    Applicant: Technion Research & Development Foundation Ltd.
    Inventor: Dina Ron
  • Human Sef isoforms and methods of using same for cancer diagnosis and gene therapy
    Patent number: 7629325
    Abstract: A method and pharmaceutical compositions useful for inhibiting the growth of solid tumors (e.g., skin caner) are provided. Specifically, the method is effected by administering to a subject in need thereof an agent capable of upregulating the expression level and/or activity of at least a functional portion of Sef, wherein the functional portion being capable of inhibiting RTK-mediated cell proliferation and whereas upregulating can be effected by: expressing in cells of the subject an exogenous polynucleotide encoding at least a functional portion of Sef (e.g., SEQ ID NOs:4, 8 or 9); increasing expression of endogenous Sef in cells of the subject; increasing endogenous Sef activity in cells of the subject; and introducing an exogenous peptide and/or exogenous polypeptide including at least a functional portion of Sef to the subject. Also provided are methods and kits for diagnosing and staging of cancer (e.g.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: December 8, 2009
    Assignee: Technion Research & Development Foundation Ltd.
    Inventor: Dina Ron
  • Human Sef isoforms and methods of using same for cancer diagnosis and gene therapy
    Publication number: 20060293240
    Abstract: A method and pharmaceutical compositions useful for inhibiting the growth of solid tumors are provided. Specifically, the method is effected by administering to a subject in need thereof an agent capable of upregulating the expression level and/or activity of at least a functional portion of Sef, wherein the functional portion being capable of inhibiting RTK-mediated cell proliferation. Also provided are methods and kits for diagnosing and staging of cancer by detecting the expression level of hSef in a tissue sample, wherein a decrease in hSef expression level is indicative of cancer.
    Type: Application
    Filed: July 27, 2006
    Publication date: December 28, 2006
    Inventor: Dina Ron
  • Human Sef isoforms and methods of using same for cancer gene therapy
    Publication number: 20060079444
    Abstract: A method and pharmaceutical compositions useful for inhibiting the growth of solid tumors are provided. Specifically, the method is effected by administering to a subject in need thereof an agent capable of upregulating the expression level and/or activity of at least a functional portion of Sef, wherein the functional portion being capable of inhibiting RTK-mediated cell proliferation.
    Type: Application
    Filed: October 11, 2004
    Publication date: April 13, 2006
    Inventor: Dina Ron