Abstract: To reduce problems associated with clotting and thrombus formation, it is now common to “lock” intravascular access catheters between successive uses. Locking typically involves first flushing the catheter with saline to remove blood and other substances from the catheter lumen. After the catheter has been flushed, an anti-coagulant solution is injected to displace the saline and fill the lumen. Use of an effective antimicrobial substance along with anticoagulant during the same process is important to reduce the possibility of bacterial contamination and subsequent infection. The present invention deals with a safe, effective and economical catheter lock flush solution with excellent antimicrobial and anticoagulant activity. The unique ratio of the active components of the catheter lock solution used in the invention i.e. Sodium salt(s) of EDTA, Ethanol and D-mannitol with a suitable pH ensures broad-spectrum antimicrobial and optimum anticoagulant activity.

Abstract: A system for subatmospheric pressure therapy in connection with healing a wound includes a wound dressing adapted for positioning relative to a wound bed and a subatmospheric pressure mechanism. The subatmospheric pressure mechanism includes a housing; a vacuum source in the housing and associated with a vacuum port; a collection canister defining an internal chamber in fluid communication with the vacuum source through the vacuum port and with the wound dressing for collecting exudates removed from the wound bed; a hydrophobic filter in fluid communication with the vacuum source and the internal chamber of the collection canister; and a screen disposed proximally of the filter. The filter is adapted to prevent exudates from reaching the vacuum source while allowing passage of air to the vacuum source.

Abstract: A system for subatmospheric pressure therapy in connection with healing a surgical or chronic wound includes a wound dressing adapted for positioning relative to a wound bed of a subject and a subatmospheric pressure mechanism. The subatmospheric pressure mechanism includes a housing; a vacuum source disposed in the housing and associated with a vacuum port; a collection canister defining an internal chamber in fluid communication with the vacuum source through the vacuum port and with the wound dressing for collecting exudates removed from the wound bed under influence of the vacuum source; a hydrophobic filter in fluid communication with the vacuum source and the internal chamber of the collection canister; and a screen disposed proximally of the filter. The filter is adapted to prevent exudates from reaching the vacuum source while allowing passage of air to the vacuum source.

Abstract: Disinfectant compositions including EDTA salt(s), Parabens and Methylene Blue. The disinfectant compositions have demonstrated activity as enhanced, fast acting catheter lock/flush solutions. They are safe for human and medical uses and may be used as prophylactic preparations to prevent infection, or to reduce the proliferation of and/or eliminate existing or established infections. In addition, the composition has anticoagulant activity and can be utilized to maintain the patency of catheters.

Abstract: A composition may include a combination of at least one chelating agent and at least one antioxidant agent, the combination may have a fractional inhibitory concentration coefficient of about 0.5 or less and/or an INR of > about 2.82.

Abstract: Disinfectant compositions comprising N-Acetyl Cysteine (NAC) and Vitamin C are disclosed. The disinfectant compositions have also demonstrated activity in inhibiting as well as killing micro-organisms responsible for generating biofilms. They are safe for human and medical uses and may be used as prophylactic preparations to reduce the proliferation of and/or eliminate existing or established infections.

Abstract: Disinfectant compositions comprising PHMB and EDTA salt(s) are disclosed. The disinfectant compositions have also demonstrated activity as enhanced, fast acting catheter lock/flush solutions. They are safe for human and medical uses and may be used as prophylactic preparations to prevent infection, or to reduce the proliferation of and/or eliminate existing or established infections.