Abstract: Methods of controlling an across-wafer profile of a semiconductor process, as well as related systems and computer program products. A target profile of a semiconductor process over a radius of a wafer is fit to a polynomial. A plurality of gain matrices between a first plurality of process inputs and a plurality of polynomial coefficients of the polynomial are determined. An offset is estimated between the plurality of polynomial coefficients and an effect of the first plurality of process inputs. An objective function is defined as an integral of a squared deviation between an estimated profile and the target profile over the radius of the wafer. A second plurality of process inputs are mapped to the objective function by vector convolution using the plurality of gain matrices. The objective function is solved to optimize the second plurality of process inputs.