Abstract: A method for constructing a structural semantic map under an underground weak-light and low-texture environment is provided. The method includes: fusing traditional methods with a parameter line detection and verification model of structural semantics of a Transformer; and establishing a geometric primitive half-plane search method guided by the direction of structural information. The method also includes establishing a neighborhood greedy expansion algorithm based on a geometric primitive model; and optimizing geometric primitive poses and boundaries one by one. The method further includes fusing a point cloud map with structural information, and establishing a semantic map with geometric structure primitives.

Abstract: The present application relates to a bifunctional fusion protein, which includes a first binding domain that specifically binds to CLDN18.2, and a second binding domain that specifically binds to a CD47 protein, wherein the second binding domain has at least one of the following characteristics: (a) binding to a CD47 protein at 4×10?8M or a lower KD value; (b) specifically blocking the interaction between CD47 protein and SIRP?; (c) not causing a coagulation reaction; and (d) inhibiting the growth and/or proliferation of a tumor or tumor cells.

Abstract: The method of the present invention includes cutting out a umbilical cord segment; filling the vessel of the umbilical cord segment with 0.01-0.5% collagenase solution; sealing both ends of the umbilical cord segment and maintaining it at a temperature of 37° C. for at least 15-45 minutes; wash the vessel with balanced normal saline solution; fill the vessel with a new 0.01-0.5% collagenase solution; seal both ends of the umbilical cord and incubate at 37° C. for at least 25-65 minutes; and equilibrate The vessel is washed with saline solution, the washed liquid is centrifuged, and the resulting pellet is incubated in a selective environment. The present invention allows to increase the yield and purity of obtained mesenchymal stem cell cultures and in some cases can reduce the time required to obtain mesenchymal stem cells.

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.

Abstract: Provided is a doorbell system, including an indoor terminal, an outdoor terminal, and a power supply (100). The indoor terminal includes a bell controller (220) and an indoor bell (210) which are connected in parallel; the outdoor terminal includes an outdoor doorbell (310) and an outdoor switch (320); the indoor terminal, the outdoor terminal, and the power supply (100) are connected in series to form a closed loop; in response to the outdoor switch (320) being switched off, the bell controller (220) is turned on, the indoor bell (210) is short-circuited, and the power supply (100) powers the outdoor doorbell (310); and in response to the outdoor switch (320) being switched on, the bell controller (220) is turned off, and the power supply (100) powers the indoor bell (210).

Abstract: The invention discloses a ground motion intensity measure optimization method for seismic response prediction. The method includes the following steps: (1) building a building damage database; (2) optimizing ground motion intensity measures; (3) constructing a machine learning model; and (4) predicting damage states. According to the method, a combination of optimal ground motion intensity measures is selected by an elastic-net algorithm, wherein the efficiency and practicability in a current selection criterion are updated based on the goodness of fit and regression coefficient of the elastic-net model, thereby avoiding an assumption that intensity measures and structure response need to obey a logarithmic linear relationship and the limitation of intensity measure dimensions in traditional methods. By using the combination of optimal ground motion intensity measures as input variables, the prediction accuracy can be remarkably improved, and meanwhile the number of samples required is reduced.

Abstract: The present invention provides a rabies virus monoclonal antibody 2F2 and universal rabies virus antibody rapid detection test paper and belongs to the technical field of biological detection. An amino acid sequence of the monoclonal antibody 2F2 is shown as SEQ ID No. 1. The monoclonal antibody 2F2 provided by the present invention specifically binds to rabies virus G proteins, and preparation of the monoclonal antibody 2F2 into test paper has the advantages of rapidity, accuracy, sensitivity, specificity and low cost.

Abstract: A data backup and recovery method and system using allocated data blocks include identifying a first snapshot associated with a virtual machine; accessing changed block tracking data associated with data changes occurred in the virtual machine, the data changes corresponding to a set of changed data blocks; accessing block allocation status data associated with the set of changed data blocks; identifying one or more allocated data blocks from the set of changed data blocks that are associated with allocated status based on the block allocation status data; and storing the one or more allocated data blocks to a storage device.

Abstract: Systems are methods are provided for training an automated agent. The automated agent maintains a reinforcement learning neural network and generates, according to outputs of the reinforcement learning neural network, signals for communicating resource task requests. First and second task data are received. The task data are processed to compute a first performance metric reflective of performance of the automated agent relative to other entities in a first time interval, and a second performance metric reflective of performance of the automated agent relative to other entities in a second time interval. A reward for the reinforcement learning neural network that reflects a difference between the second performance metric and the first performance metric is computed and provided to the reinforcement learning neural network to train the automated agent.

Abstract: A drilling device for geotechnical engineering investigation is provided, including an outer supporting ring seat, where a center of the outer supporting ring seat is rotatably connected with a middle supporting ring seat through a first supporting shaft rod; a center of the middle supporting ring seat is rotatably connected with an inner supporting ring seat through a second supporting shaft rod; the first supporting shaft rod and the second supporting shaft rod are vertically crossed; a second rotating motor is fixedly installed at one end of the first supporting shaft rod on an outer surface of the outer supporting ring seat; a pow output end of the second rotating motor is fixedly connected with the first supporting shaft rod, an other end of the first supporting shaft rod is provided with a first locking mechanism for position limitation.

Abstract: A semiconductor device and a method of making the same are provided. A first die and a second die are placed over a carrier substrate. A first molding material is formed adjacent to the first die and the second die. A first redistribution layer is formed overlying the first molding material. A through via is formed over the first redistribution layer. A package component is on the first redistribution layer next to the copper pillar. The package component includes a second redistribution layer. The package component is positioned so that it overlies both the first die and the second die in part. A second molding material is formed adjacent to the package component and the first copper pillar. A third redistribution layer is formed overlying the second molding material. The second redistribution layer is placed on a substrate and bonded to the substrate.

Abstract: A semiconductor device includes a substrate provided with an integrated circuit and a contact, an interlayer dielectric layer covering the integrated circuit and the contact, a through electrode penetrating the substrate and the interlayer dielectric layer, a first intermetal dielectric layer on the interlayer dielectric layer, and first and second wiring patterns in the first intermetal dielectric layer. The first wiring pattern includes a first conductive pattern on the through electrode, and a first via penetrating the first intermetal dielectric layer and connecting the first conductive pattern to the through electrode. The second wiring pattern includes a second conductive pattern on the contact, and a second via penetrating the first intermetal dielectric layer and connecting the second conductive pattern to the contact. A first width in a first direction of the first via is greater than a second width in the first direction of the second via.

Abstract: Provided is a pre-applied waterproofing membrane having a waterproofing adhesive layer and an outer particle layer comprising synthetic polymer granules to protect the adhesive layer and to facilitate detailing at membrane-to-membrane overlaps. In preferred embodiments, the synthetic polymer granules are made from polymers selected from the group consisting of polyvinyl acetate, acrylic, and styrene butadiene copolymers or polymers. Most preferably, the synthetic polymer granules have round or spherical shapes that help to facilitate detailing at the building or installation site, such as sealing at membrane overlaps, and sealing around pipes or other details. Alternatively, the membranes may be made having side edges which are free of synthetic polymer granules, whereby a removable release liner strip can be used to prevent adhesive from sticking to the back of the membrane when the membrane is rolled up on itself for shipment.

Abstract: Aspects of the subject disclosure may include, for example, detecting a plurality uplink data packets on a network, the plurality of uplink data packets conveying application protocol messages from an application on a mobile device to an application server providing a service to the application on the mobile device over the network; providing data packets of the plurality uplink data packets to a machine learning model, the machine learning model trained to identify respective application protocol messages from the data packets; receiving from the machine learning model an indication that a start video download application protocol message has been identified by the machine learning model, the start video download application protocol message requesting initiation of a video download to the application on the mobile device from the application server; detecting a plurality of downlink data packets on the network, the plurality of downlink data packets conveying video content data to the mobile device in respo

Abstract: Provided are an alternating current field based defect identification method and an array detection probe. The evaluation method includes the following steps: obtaining a magnetic field Bx signal in direction X and a magnetic field Bz signal in direction Z; removing a background magnetic field of each of the magnetic field Bx signal in the direction X and the magnetic field Bz signal in the direction Z, and obtaining a magnetic field Bx1 signal in the direction X and a magnetic field Bz1 signal in the direction Z without background magnetic fields; drawing an array image of the Bx1 signal and an array image of the Bz1 signal; and locating a distortion zone corresponding to disturbance at the same time and position in the array image of the Bx1 signal and the array image of the Bz1 signal.

Abstract: A preparation method of a Pueraria lobata nano-silver composite hydrosol includes: dispersing Pueraria lobata powder in water, then heating to perform gelatinization, then adjusting a pH value, then sequentially adding an alkyl polyglucoside solution, a silver nitrate solution, and a sodium chloride solution, and performing a reaction by microwave heating to obtain the Pueraria lobata nano-silver composite hydrosol. The Pueraria lobata nano-silver composite hydrosol promotes seed germination of a Polygonatum Mill genus, and is applied in antibiotic detection and agricultural sterilization used as a fungicide.

Abstract: If a first group selection setting is set to TRUE, an NVM Express (NVMe) processor sends a first set of NVMe status information that includes a transfer data end event. If a second group selection setting is set to TRUE, the NVMe processor sends a second set of NVMe status information that includes an NVMe error event. A firmware functional module sends firmware status information. The aggregation module aggregates and timestamps the first and second sets of NVMe status information, if any, and the firmware status information to obtain a timestamped and aggregated message stream that is output by an interface. The timestamped and aggregated message stream enables a visualization system to analyze the NVMe processor and the firmware functional module. The NVMe processor, firmware functional module, aggregation module, and interface are in a storage controller, implemented on a system on chip (SOC), that manages a storage medium.