Abstract: Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.

Abstract: An approach for separating a gaseous mixture includes a multi-stage membrane system in which a rubbery membrane is operated at a low temperature. Various streams are cooled and heated in a multi-fluid heat exchanger. In specific configurations, the multi-fluid heat exchanger is cooled by using no fluids other than fluids derived from the permeate and/or residue generated in the first membrane stage.

Abstract: Thaxtomins are phytotoxic secondary metabolites produced in plant pathogenic Streptomyces strains and have received considerable interests as bioherbicides. A cell-free, biocombinatorial approach was developed to produce a thaxtomin library for herbicide development. Combination of biosynthetic enzymes led to the production of 136 substituted 2,5-diketopiperazines, thaxtomin D, thaxtomin B and thaxtomin A analogs in a single pot. Furthermore, rational engineering of TxtA allowed the synthesis of azido-containing thaxtomin analog. Selected unnatural thaxtomins demonstrated improved herbicidal activities. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: A system, method and gateway are provided. The method is executed by a primary gateway, and includes obtaining status information from smart devices, a first portion of which belong to and communicate with the primary gateway using a first standard, and a second portion of which belong to and communicate with a secondary gateway using a second standard. The status information from the smart devices belonging to the secondary gateway is received from the secondary gateway, and the status information from the smart devices belonging to the primary gateway is received directly from the smart devices belonging to the primary gateway. A control instruction for controlling a second smart device is generated in response to status information from a first smart device complying with an interworking rule, where the first and second smart devices communicate using different standards. The control instruction is transmitted to the second smart device.

Abstract: The disclosure relates to devices and methods for analyzing particles in a sample. In various embodiments, the present disclosure provides devices and methods for cytometry and additional analysis. In various embodiments, the present disclosure provides a cartridge device and a reader instrument device, wherein the reader instrument device receives, operates, and/or actuates the cartridge device. In various embodiments, the present disclosure provides a method of using a device as disclosed herein for analyzing particles in a sample.

Abstract: The present invention discloses a seat rotation locking mechanism, including a locking mechanism mounted on a rotating disc in a seat rotation mechanism and at least one lockhole disposed on an outer circumference of a fixed disc in the seat rotation mechanism, where the locking mechanism includes: a lock support fixed on the rotating disc; and at least two lock pins horizontally and moveably configured in the lock support, where a first end of the lock pin is of a truncated-cone-shaped structure; and the first end of the lock pin is inserted into the lockhole, to implement zero-clearance locking by using wedging between the truncated-cone-shaped structure of the first end of the lock pin and the lockhole. The present invention eliminates a fit clearance existing after a rotation mechanism is locked, improves a grade of a product, and improves user experience.

Abstract: The disclosure relates to a method for repairing an internal circuit break defect in a chip, including: S1, detecting the defect position of the chip and the type and performance parameters of a filling material; S2, positioning the chip on a two-dimensional motion platform; S3, setting parameters of two beams of laser; adjusting a focal length of the two beams of laser three-dimensional incident angle and a Z axis, so that a focus point of the two beams of laser irradiate any end of the circuit break of the chip; S4, the two-dimensional motion platform drives the chip to move, so that the focus point of the two beams of laser is moved to an other end of the circuit break, and an moving trajectory of the focus point of the two beams of laser feeds through the two ends of the circuit break of the chip.

Abstract: A method for estimating a wrench acting on a reference point of a robot includes the steps of: a) measuring at least one component, but not all components, of the wrench; and b) estimating non-measured components of the wrench based on a dynamical model of the robot while taking into account the measured components.

Abstract: The invention discloses a fixed bed counter-current regeneration device for ion exchange resin and the method of use, relates to the field of ion exchange resin regeneration. The device comprises a cyclone separator, a regeneration reactor, a fully mixed resin reactor, a desorption solution storage tank, and a regenerant storage tank, wherein the cyclone separator is placed on top of the regeneration reactor, the upper part of the cyclone separator is connected to the fully mixed resin reactor.

Abstract: The invention relates to a method of increasing the coercivity of a sintered type NdFeB permanent magnet. The method comprises the following steps: a) preparing of an organic film with a predetermined thickness on a surface of the sintered type NdFeB permanent magnet; b) creating holes in the organic film according to a given pattern with the holes extending to the surface of the sintered type NdFeB permanent magnet; c) filling the holes with a metal powder, the metal powder including or consisting of at least one of Dy and Tb; and d) performing a thermally induced grain boundary diffusion process.

Abstract: A pen, a method for detecting a pen, and a touch system are disclosed. The pen is configured to operate on a touch panel. The pen includes a controller, a transmitting electrode, and a receiving electrode. The transmitting electrode and the receiving electrode are at different positions of the pen. The receiving electrode is configured to receive a first signal transmitted by the touch panel and transmit the first signal to the controller. The controller is configured to receive the first signal, determine an inclination angle between the pen and the touch panel according to a signal amount of the first signal, generate a second signal by using an encoding format corresponding to the inclination angle, and transmit the second signal to the transmitting electrode. The transmitting electrode is configured to receive the second signal and transmit the second signal to the touch panel.

Abstract: A microwave sensor device is for detecting activity and for sending and/or receiving a communications signal to/from a second microwave sensor device. A microwave transceiver is used for transmitting a microwave transmit signal and for receiving a microwave receive signal. For motion detection, the microwave receive signal is a reflected version of the microwave transmit signal and the signals are processed to identify first signal characteristics. For communication, the microwave transmit signal is a communications signal for detection at another sensor device. The transmit and microwave receive signals are processed to identify second characteristics. This sensor device detects motion and also transmits and/or receives a communications signal using the same transceiver. In particular, the communications signal is designed to be detected by a remote sensor device in the same way as for motion detection.

Abstract: An ultrasonic induction circuit is provided, a first electrode of an ultrasonic sensor is electrically connected with a first terminal of the ultrasonic sensing circuit, a second electrode is electrically connected with a second terminal of a first potential supply sub-circuit, and the first terminal of the first potential supply sub-circuit is electrically connected with a first potential supply end. A gate of M1 is electrically connected with the second electrode and the second terminal of the compensation sub-circuit. The second electrode is electrically connected with the first terminal of the compensation sub-circuit. The first electrode is coupled to the second potential supply end. The first terminal of the signal output sub-circuit is electrically connected to the second electrode of the first transistor, and the second terminal is electrically connected to the second terminal of the ultrasonic induction circuit.

Abstract: The present invention discloses a seat rotation locking mechanism, including a locking mechanism mounted on a rotating disc in a seat rotation mechanism and at least one lockhole disposed on an outer circumference of a fixed disc in the seat rotation mechanism, where the locking mechanism includes: a lock support fixed on the rotating disc; and at least two lock pins horizontally and moveably configured in the lock support, where a first end of the lock pin is of a truncated-cone-shaped structure; and the first end of the lock pin is inserted into the lockhole, to implement zero-clearance locking by using wedging between the truncated-cone-shaped structure of the first end of the lock pin and the lockhole. The present invention eliminates a fit clearance existing after a rotation mechanism is locked, improves a grade of a product, and improves user experience.

Abstract: An interference source identification method includes obtaining a first parameter, where the first parameter includes a co-channel interference rate of a first access point in a preset time period, a receive channel utilization rate and a transmit channel utilization rate of a second access point in the preset time period, and a receive frame rate of data received from a first station by the second access point in the preset time period, and determining that the data causes co-channel interference to the first access point when the first parameter meets a preset condition.

Abstract: A repair process for an article such as an airfoil includes providing an article that has a substrate and a ceramic barrier coating disposed on the substrate, where the ceramic barrier coating has a damaged region, abrading the damaged region to provide dimple in the ceramic barrier coating, wherein a remaining region of the ceramic barrier coating adjacent the dimple remains intact, and depositing a patch of networked ceramic nanofibers in the dimple.

Abstract: A feed containing methane and nitrogen gas is processed in a three-stage membrane system, each stage of which is selective for methane over nitrogen. The methane enriched permeate from the first stage is removed as product gas. The methane-depleted residue from the second stage is purified in second and third cascaded stages to provide second and third permeates and second and third residues. The third stage permeate is recycled to the feed.

Abstract: This application provides a frequency scaling method. The method includes: predicting an energy efficiency parameter for processing a current frame of an image by at least one module; and selecting, from a plurality of frequency sets based on the predicted energy efficiency parameter, a first frequency set that meets an energy efficiency requirement, and scaling a working frequency of each of the at least one module for processing the current frame to a preset frequency corresponding to each of the at least one module. According to the technical solutions provided in the embodiments of this application, a load change requirement can be responded to in time in a frequency scaling process.

Abstract: Provided herein are methods and compositions to extract and enrich by, physical separation or amplification, relatively short nucleic acids from a nucleic acid composition containing a high background of longer nucleic acids (e.g., host or maternal nucleic acids; genomic nucleic acid and the like).