Abstract: Provided herein are CRISPR/Cas9 complexes and method of using same.

Abstract: A method for intraoperative planning and facilitating a revision arthroplasty procedure includes displaying a virtual model of a bone, capturing positions of a tracked probe as the tracked probe contacts points at a perimeter of a primary implant component coupled to the bone, generating a virtual representation of an interface between the primary implant component and the virtual model of the bone using the positions of the tracked probe, planning a bone resection using the virtual representation of the interface, and guiding execution of the bone resection.

Abstract: The present invention provides a method of decreasing side effects in a human or animal cancer patient due to radiation therapy or chemotherapy. With this method, methionine enkephalin is administered to the patient at least one time per week for a first time period, where the first time period is at least three weeks. In one embodiment, the first time period is one or two months. Methionine enkephalin is then administered to the patient one time per month for a second time period, where the second time period is at least one month, and where the second time period is consecutive to the first time period. In one embodiment, the total term of methionine enkephalin treatment is at least six months. Methionine enkephalin may be administered to the patient at the same time as, before, or after administration of radiation or chemotherapy.

Abstract: The present invention provides a method of stimulating dendritic cells, comprising contacting the dendritic cells with methionine enkephalin. The present invention also provides methods of enhancing an immune response to an antigen in a mammal. In a first method, dendritic cells are isolated from the mammal. The dendritic cells are then contacted with methionine enkephalin for a time sufficient to stimulate the cells. Next, the stimulated dendritic cells are contacted with the antigen of interest for a time sufficient for the cells to process the antigen. The dendritic cells are then injected into the mammal. The dendritic cells may be injected into the animal either on their own, or along with methionine enkephalin and/or the antigen. In a second method, the antigen of interest and methionine enkephalin are administered to the mammal. The present invention also provides compositions for administration to a mammalian subject having a tumor.

Abstract: Novel peptides having substantially the amino acid sequence:X-Gly-Asn-Gly-Asp-Glu-Gln-Pro-Leu-Thr-Y,where X is H, a single amino acid or a short-chain peptide and Y is OH, NH.sub.2, a single aminoacid or a short-chain peptide. These peptides have natriuretic and diuretic activity.

Abstract: Biologically active atrial peptide analogs having 21 or 22 amino acid residues are provided with potent diuretic and natriuretic activities, and which lower blood pressure. These analogs have a .beta.-mercaptopropanoic acid derivative moiety at the N-terminus and have D-Alanine at the 3 position of the amino acid sequence.

Abstract: A synthetic peptide growth hormone releasing factor having substantially the following amino acid sequence: ##STR1## methods of inducing growth in an animal and growth inducing pharmaceutical compositions, including animal feed compositions, are disclosed.