Abstract: A highly effective pure, natural, ingestible antidiabetic may be made from Shilianhua (Echevaria glauca, Sinocrassula berger, Crassulaceae) by washing leaves and/or stems of the Shilianhua plant, crushing them in a grinder, breaking the cell walls to form a filterable material, filtering the material to produce a filtrate, and decompressing and concentrating the filtrate to produce a concentrated solution. The cell walls may be broken using medical alcohol, quick freezing and thawing, or ultrasonic mixing. The concentrated solution is then made into a powder, or concentrated powder, by baking, crushing, and passage through a 60 mesh screen; using a silica gel column; using a Saphadex column; or by treatment with a CH.sub.3 COOC.sub.2 H.sub.5 solution. Treatment of, or to prevent, diabetes by lowering blood sugar at least 10% (e. g.