Patents by Inventor Dingjun CHU

Dingjun CHU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PREPARING FINERENONE AND INTERMEDIATE THEREOF
    Publication number: 20250092034
    Abstract: A method for preparing a finerenone intermediate compound of formula I from a diastereomeric tartrate by means of racemic resolution is provided. A compound of formula I having an ee value higher than 99.5% can be obtained. The preparation method provided has mild reaction conditions, simple post-treatment, and no special reagents required, and is suitable for industrial production.
    Type: Application
    Filed: December 28, 2022
    Publication date: March 20, 2025
    Inventors: Zhigang XIONG, Jian TANG, Yong SUN, Chao ZHANG, Jiadong WEI, Dingjun CHU
  • Method for preparing fluticasone furoate
    Patent number: 8969547
    Abstract: Method for preparing fluticasone furoate (6?,9?-difluoro-11?-hydroxy-16?-methyl-17?-[(2-furoyl)oxy]-3-oxo-androsta-1,4-diene-17?-carbothioic acid S-fluoromethyl ester) by directly subjecting a compound of Formula III and a complex of a fluoromethylating reagent in presence of an organic base to a replacement reaction to obtain the target compound. Generation of impurities in a process via Compound IV is avoided; the method is simple with mild reaction conditions, suitable for industrial production, and yields products with purity of 98% by HPLC.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: March 3, 2015
    Assignees: Zhejiang Tiantai Aurisco Pharmaceuticals Co. Ltd., Shanghai Aurisco Industry Co., Ltd.
    Inventors: Dingjun Chu, Haijie Ji, Xiangxian Hong
  • METHOD FOR PREPARING FLUTICASONE FUROATE
    Publication number: 20130274461
    Abstract: Method for preparing fluticasone furoate (6?,9?-difluoro-11?-hydroxy-16?-methyl-17?-[(2-furoyl)oxy]-3-oxo-androsta-1,4-diene-17?-carbothioic acid S-fluoromethyl ester) by directly subjecting a compound of Formula III and a complex of a fluoromethylating reagent in presence of an organic base to a replacement reaction to obtain the target compound. Generation of impurities in a process via Compound IV is avoided; the method is simple with mild reaction conditions, suitable for industrial production, and yields products with purity of 98% by HPLC.
    Type: Application
    Filed: June 7, 2013
    Publication date: October 17, 2013
    Inventors: Dingjun CHU, Haijie Ji, Xiangxian Hong
  • METHOD FOR PREPARATION OF FLUTICASONE PROPIONATE
    Publication number: 20080125407
    Abstract: Taught is a method for preparing S-fluoromethyl-6?,9?-difluoro-11?-hydroxy-16?-methyl-17?-propionyloxy-3-oxoandrosta-1,4-diene-17?-carbothioate (fluticasone propionate). The present method is simple, convenient, and mild, yields highly pure product, and is suitable for use commercially on a large scale.
    Type: Application
    Filed: January 26, 2008
    Publication date: May 29, 2008
    Applicant: SHANGHAI AURISCO INTERNATIONAL TRADING CO., LTD.
    Inventors: Dingjun CHU, Defa ZHANG