Abstract: A method for performing multi-slice MR Elastography on an anatomical region of interest associated with a patient includes inducing shear waves at a shear wave frequency value (e.g., between 25-500 Hz) in the anatomical region of interest using an external driver. Next, the anatomical region of interest is imaged during a single patient breath-hold using an MRI acquisition process. Following the MRI acquisition process(es), phase images of the anatomical region of interest are generated based on an acquired RF signal. These phase images may then be processed (e.g., using an inversion algorithm) to generate one or more quantitative images depicting stiffness of the anatomical region of interest. In some embodiments, a wave image is also generated showing propagation of the plurality of shear waves through the anatomical region of interest based on the phase images.

Abstract: A method for generating a perfusion weighted image using ASL with segmented acquisitions includes dividing an anatomical area of interest into slices and performing an EPI acquisition process using an MRI system to acquire a control image dataset representative of the slices. An ASL preparation process is performed using the MRI system to magnetically label protons in arterial blood water upstream from the anatomical area of interest. Following a first time period, a multi-band EPI acquisition process is performed using the MRI system to acquire a first labeled image dataset representative of a first subset of the slices. Following a second time period, another multi-band EPI acquisition process is performed using the MRI system to acquire a second labeled image dataset representative of a second subset of the slices. A perfusion weighted image is generated by subtracting the first and second labeled image dataset from the control image dataset.

Abstract: A magnetic resonance method and system are provided for providing improved multi-band (MB) magnetic resonance imaging. The adaptive MB imaging can be achieved by providing one or more modified multi-band excitation pulse sequences that include at least either one nullified “dummy” slice within a slab that is not excited simultaneously with the other slices during a single multislice acquisition sequence, or one excitation slice group that utilizes a non-uniform slice spacing between simultaneously excited slices. Adaptive GRAPPA or slice-GRAPPA kernel sizes can also be used during image reconstruction to improve speed without excessive point spread blurring or MB reconstruction failure. A total leakage factor (TLF) can also be determined based on test images using modified MB excitation sequences, and used to improve the adaptive MB procedure.

Abstract: A method for performing multi-slice MR Elastography on an anatomical region of interest associated with a patient includes inducing shear waves at a shear wave frequency value (e.g., between 25-500 Hz) in the anatomical region of interest using an external driver. Next, the anatomical region of interest is imaged during a single patient breath-hold using an MRI acquisition process. Following the MRI acquisition process(es), phase images of the anatomical region of interest are generated based on an acquired RF signal. These phase images may then be processed (e.g., using an inversion algorithm) to generate one or more quantitative images depicting stiffness of the anatomical region of interest. In some embodiments, a wave image is also generated showing propagation of the plurality of shear waves through the anatomical region of interest based on the phase images.

Abstract: A computer-implemented method for performing multi-band slice accelerated imaging includes performing a low-resolution fast multi-dimensional reference scan to obtain a coil sensitivity map. A multiband imaging scan is performed to acquire a plurality of k-space lines representative of an anatomical area of interest. A multi-band signal corresponding to the plurality of k-space lines is separated into a plurality of image slices using a parallel imaging reconstruction technique and the coil sensitivity map.

Abstract: A method to serially determine changes in perfusion to tissues is provided. This method involves injecting contrast material into a catheter that is positioned in the blood supply proximal to the targeted tissue of interest, acquiring a time series of images that depicts the uptake of this contrast material within the tissue, deriving semi-quantitative or quantitative perfusion metrics based upon the time series of perfusion images, altering perfusion to the targeted tissue by means of injecting pharmacologic agents or embolic agents into the blood vessels supplying the targeted tissue, repeating the acquisition of perfusion images to serially monitor changes in tissue perfusion after each alteration, and calculating changes in perfusion metrics after each series of perfusion images. This method is used to monitor changes in perfusion to various tissues, including a diverse array of tumors.

Abstract: A method to serially determine changes in perfusion to tissues is provided. This method involves injecting contrast material into a catheter that is positioned in the blood supply proximal to the targeted tissue of interest, acquiring a time series of images that depicts the uptake of this contrast material within the tissue, deriving semi-quantitative or quantitative perfusion metrics based upon the time series of perfusion images, altering perfusion to the targeted tissue by means of injecting pharmacologic agents or embolic agents into the blood vessels supplying the targeted tissue, repeating the acquisition of perfusion images to serially monitor changes in tissue perfusion after each alteration, and calculating changes in perfusion metrics after each series of perfusion images. This method is used to monitor changes in perfusion to various tissues, including a diverse array of tumors.