Abstract: Systems and methods for a tubing disconnect assembly are disclosed. In an embodiment the system includes a first bioprocessing unit, a second bioprocessing unit, a flexible tubing in fluid communication with the first and second bioprocessing unit, and a tubular collar having a middle portion sandwiched between a first and second swaged end portions, and secured around at least a portion of the tubing, the collar configured to be disconnected by a disconnecting device in the middle region extending between the first and second swaged end portions.

Abstract: A system and method for clinical decision support include a processor configured to receive a clinical service request; parse the clinical service request into a set of semantic tokens, classify the clinical service request according to the type, severity, and urgency of the clinical service request; execute a preliminary triage operation with the semantic tokens to identify a relevant clinical rule and a primary workflow for responding to the clinical service request based on a classification and/or label, the relevant clinical rule and primary workflow are each unique and tailored for a specific medical service provider organization; generate a decision support recommendation based on the relevant clinical rule and primary workflow; and transfer the decision support recommendation to an organizational processing subsystem for the specific medical service provider organization based on the primary workflow.

Abstract: The present invention relates to a battery comprising: -i) at least two electrochemical elements (d) connected to one another by a connection part (c), each electrochemical element comprising a container, -ii) a material arranged between said at least two electrochemical elements, and -iii) at least one disconnection device, said device comprising: a heat-activatable element (a) able to deform when its temperature reaches a threshold value, the heat-activatable element being arranged such that, when its temperature reaches said threshold value, it disconnects the connection part (c) from at least one electrochemical element (d) through its deformation, said heat-activatable element not contributing to the conduction of electric current when an electric current flows through said electrochemical elements, said heat-activatable element being placed in contact with the connection part (c) and with a current output terminal.

Abstract: The present invention is directed to a method for treating a neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer disease, Parkinson's disease, Huntington's disease, frontotemporal degeneration, dementia with Lewy bodies, a motor neuron disease, or a demyelinating disease. The method comprises administering to a subject in need thereof a Ppargc1a activator 2-(4-tert-butylphenyl)-1H-benzimidazole, 2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole, in an effective amount. A preferred route of administration is oral administration.

Abstract: Methods are presented for selecting a subject for treatment with a 2-arylbenzimidazole compound of Formula I, or salt, hydrate, deuterated analog, or fluorinated analog thereof, based on the inflammatory phenotype of circulating myeloid cells. Methods are also provided for treating, slowing the progression of, and delaying the onset of neurodegenerative disease in a subject who has not been diagnosed with a neurodegenerative disease but is at risk of developing a neurodegenerative disease or cognitive impairment, comprising selecting the subject for treatment based on the inflammatory phenotype of circulating myeloid cells and administering a therapeutically effective amount of compound of Formula I or salt, hydrate, deuterated analog, or fluorinated analog thereof.

Abstract: This document describes a virtual sensor module for generating spatial-temporal temperature measurements of a battery and a method of using the virtual sensor module to generate the above-mentioned measurements. The virtual sensor module utilizes a Proportional-Integral-Derivative (PID) controller module communicatively coupled to a trained convolutional neural network—long-short-term memory (CNN-LSTM) module to trigger the trained CNN-LSTM module to generate a refined predicted series of real temperature sequences across the battery, based on a set of optimized PID parameters (K*p, K*i, K*d), predicted error sequences, and measured temperature sequences of the battery.

Abstract: Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to a medical device. The device can include an elongate core member having a distal portion configured to be intravascularly positioned at a treatment site within a blood vessel lumen, and an interventional element connected to the distal portion of the elongate core member. The interventional element includes a body that is expandable from a first configuration to a second configuration and an electrically conductive radiopaque marker coupled to the body. An electrically conductive lead has a distal portion electrically coupled to the radiopaque marker and a proximal portion configured to be electrically coupled to a current source.

Abstract: The present invention is directed to a method for preventing and/or treating aging-related cognitive impairment in the central nervous system. The method comprises administering to a subject in need thereof a Ppangela activator 2-(4-tert-butylphenyl)-1H-benzimidazole, 2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole, in an effective amount. A preferred route of administration is oral administration.

Abstract: A method of using an extractor for extracting harmful chemicals and particulates from air for a soldering iron station, the extractor including an intake assembly, a filter assembly, a fan, and an exhaust assembly, comprising receiving harmful chemicals, particulates, and air from the soldering iron station through the intake assembly; filtering the fumes from the air with the filter assembly; and exhausting the filtered air with the exhaust assembly.

Abstract: Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to a medical device. The device can include an elongate core member having a distal portion configured to be intravascularly positioned at a treatment site within a blood vessel lumen, and an interventional element connected to the distal portion of the elongate core member. The interventional element includes a body that is expandable from a first configuration to a second configuration and an electrically conductive radiopaque marker coupled to the body. An electrically conductive lead has a distal portion electrically coupled to the radiopaque marker and a proximal portion configured to be electrically coupled to a current source.

Abstract: An apparatus includes a Dewar having an endcap. The apparatus also includes a heat sink and a multiaxial thermal shoe having a thermal interface material and configured to thermally couple the endcap of the Dewar to the heat sink via one of at least two axial surfaces. The multiaxial thermal shoe is configured to transfer thermal energy between the endcap of the Dewar and the heat sink without structurally coupling the Dewar to the heat sink. The multiaxial thermal shoe may be configured to hold the thermal interface material against the endcap. The multiaxial thermal shoe may couple to the heat sink via a first axial surface in-line with an optical centerline or a second axial surface crosswise to the optical centerline.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, includes an occlusive device comprising a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has an undulating contour across at least a portion of one or both of its length or its width. The mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm.

Abstract: Provided are devices and methods for injecting viable transplant tissues into a subject. The device includes a fluid exchange chamber having a funneled portion connected to a pre-injection tube. The chamber includes fluid transfer holes and is disposed in an outer shell having a central bore connecting a top inlet and a bottom outlet from which the pre-injection tube exits the shell. A plunger having a central channel and a tapered bottom is disposed in the central bore such that the tapered bottom mates the funneled bottom when depressed and a stylet plunger is disposed in the central channel of the plunger.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, includes an occlusive device comprising a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has an undulating contour across at least a portion of one or both of its length or its width. The mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm.

Abstract: A process for synthesizing phosphoramidites by immobilizing a phosphitylating agent on an activated resin to create a loaded resin and then bringing the loaded resin into contact with a suitable substrate. The phosphoramidites are synthesized within minutes from applying the starting materials. Thus, the process makes it possible to create specific phosphoramidites on-demand as they are needed in further applications. The substrates to be applied are mostly nucleosides, thus to create nucleoside phosphoramidites for subsequent oligonucleotide synthesis.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, includes an occlusive device comprising a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has an undulating contour across at least a portion of one or both of its length or its width. The mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm.

Abstract: Embodiments of the inventive concept provide a system and method that verifies a user through a security token combined with biometric information processing techniques capable of changing and canceling the conventional encryption key without storing biometric information-related data corresponding to a user's personal information.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, includes an occlusive device comprising a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has an undulating contour across at least a portion of one or both of its length or its width. The mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm.

Abstract: A soldering iron hand piece that may be used for both a soldering tip and a soldering cartridge, allowing the same hand piece to be used for both a soldering tip and a soldering cartridge.

Abstract: An electric carpet stapler comprises a trigger and switch assembly that has an actuation caused by a change of state of a sensor, which causes the sensor to send a signal to a control circuit to begin a process to supply power to a winding. The trigger and switch assembly includes a trigger that moves in a trigger actuation direction to move a sensor actuator in a sensor actuation direction, causing a change of state in the sensor, which causes the control circuit to begin the process to supply power to the winding. The trigger and switch assembly may also include a toggle. At the actuation of the trigger and switch assembly, the toggle creates a mechanical instability, and a toggle signal to the user, which may be produced mechanically.