Patents by Inventor Dinko ZIHER

Dinko ZIHER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Seco macrolide compounds
    Patent number: 11512096
    Abstract: The present invention relates to seco (opened ring) macrolide compounds, to the process for preparation thereof, to the use of said seco macrolide compounds as intermediates for preparation of macrolide based macrocycles, to macrolide based macrocycles obtained from said seco macrolide compounds, to the process for preparation of macrolide based macrocycles, to the pharmaceutical compositions comprising macrolide based macrocycles, and to the use of macrolide based macrocycles as therapeutic agents.
    Type: Grant
    Filed: December 24, 2020
    Date of Patent: November 29, 2022
    Assignee: SELVITA D.O.O.
    Inventors: Andrea Fajdetic, Maja Matanovic Skugor, Ivaylo Jivkov Elenkov, Goran Kragol, Mirjana Bukvic, Zorica Marusic Istuk, Sanja Kostrun, Dinko Ziher, Renata Rupcic, Kristina Butkovic, Marko Duksi, Ivana Ozimec Landek, Dijana Pesic, Antun Hutinec, Milan Mesic, Gordon Saxty, Visnja Poljak
  • PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES
    Publication number: 20220169653
    Abstract: The present invention relates to pyrrolopyrimidine compounds according to Formula I and their use in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases. In a particular aspect, the present compounds are ASK inhibitors, particularly ASK1 inhibitors. The present invention also provides methods for the production of a compound of the invention, pharmaceutical compositions comprising a compound of the invention, the use of the compounds in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases.
    Type: Application
    Filed: September 3, 2021
    Publication date: June 2, 2022
    Inventors: David AMANTINI, Milan MESIC, Gordon SAXTY, Tanja POLJAK, Ines VUJASINOVIC, Dinko ZIHER, David WITTY, Karl Richard GIBSON
  • Pyrrolopyrimidine and pyrrolopyridine derivatives
    Patent number: 11136325
    Abstract: The present invention relates to pyrrolopyrimidine compounds according to Formula I and their use in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases. In a particular aspect, the present compounds are ASK inhibitors, particularly ASK1 inhibitors. The present invention also provides methods for the production of a compound of the invention, pharmaceutical compositions comprising a compound of the invention, the use of the compounds in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: October 5, 2021
    Assignee: GALAPAGOS NV
    Inventors: David Amantini, Milan Mesic, Gordon Saxty, Tanja Poljak, Ines Vujasinovic, Dinko Ziher, David Witty, Karl Richard Gibson
  • SECO MACROLIDE COMPOUNDS
    Publication number: 20210198278
    Abstract: The present invention relates to seco (opened ring) macrolide compounds, to the process for preparation thereof, to the use of said seco macrolide compounds as intermediates for preparation of macrolide based macrocycles, to macrolide based macrocycles obtained from said seco macrolide compounds, to the process for preparation of macrolide based macrocycles, to the pharmaceutical compositions comprising macrolide based macrocycles, and to the use of macrolide based macrocycles as therapeutic agents.
    Type: Application
    Filed: December 24, 2020
    Publication date: July 1, 2021
    Inventors: Andrea FAJDETIC, Maja MATANOVIC SKUGOR, Ivaylo Jivkov ELENKOV, Goran KRAGOL, Mirjana BUKVIC, Zorica MARUSIC ISTUK, Sanja KOSTRUN, Dinko ZIHER, Renata RUPCIC, Kristina BUTKOVIC, Marko DUKSI, Ivana OZIMEC LANDEK, Dijana PESIC, Antun HUTINEC, Milan MESIC, Gordon SAXTY, Visnja POLJAK
  • Seco macrolide compounds
    Patent number: 10919910
    Abstract: The present invention relates to seco (opened ring) macrolide compounds, to the process for preparation thereof, to the use of said seco macrolide compounds as intermediates for preparation of macrolide based macrocycles, to macrolide based macrocycles obtained from said seco macrolide compounds, to the process for preparation of macrolide based macrocycles, to the pharmaceutical compositions comprising macrolide based macrocycles, and to the use of macrolide based macrocycles as therapeutic agents.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: February 16, 2021
    Assignee: FIDELTA D.O.O.
    Inventors: Andrea Fajdetic, Maja Matanovic Skugor, Ivaylo Jivkov Elenkov, Goran Kragol, Mirjana Bukvic, Zorica Marusic Istuk, Sanja Kostrun, Dinko Ziher, Renata Rupcic, Kristina Butkovic, Marko Duksi, Ivana Ozimec Landek, Dijana Pesic, Antun Hutinec, Milan Mesic, Gordon Saxty, Visnja Poljak
  • PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES
    Publication number: 20200165259
    Abstract: The present invention relates to pyrrolopyrimidine compounds according to Formula I and their use in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases. In a particular aspect, the present compounds are ASK inhibitors, particularly ASK1 inhibitors. The present invention also provides methods for the production of a compound of the invention, pharmaceutical compositions comprising a compound of the invention, the use of the compounds in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases.
    Type: Application
    Filed: July 12, 2018
    Publication date: May 28, 2020
    Inventors: David AMANTINI, Milan MESIC, Gordon SAXTY, Tanja POLJAK, Ines VUJASINOVIC, Dinko ZIHER, David WITTY, Karl Richard GIBSON
  • MODULATORS OF HEDGEHOG (HH) SIGNALLING PATHWAY
    Publication number: 20200055847
    Abstract: There are described compounds of formula (I): and there use as a medicament in the treatment of conditions involving abnormal activation and/or malfunction of the of the hedgehog pathway, such as cancer, fibrosis and chronic graft-versus-host disease (cGVHD).
    Type: Application
    Filed: October 25, 2017
    Publication date: February 20, 2020
    Applicant: e-Therapeutics PLC
    Inventors: Maja ROSCIC, Filip KOLUNDZIC, Dinko ZIHER, Tanja POLJAK, Srinivasamurthy VADLAMUDI, Colin STUBBERFIELD
  • SECO MACROLIDE COMPOUNDS
    Publication number: 20200017522
    Abstract: The present invention relates to seco (opened ring) macrolide compounds, to the process for preparation thereof, to the use of said seco macrolide compounds as intermediates for preparation of macrolide based macrocycles, to macrolide based macrocycles obtained from said seco macrolide compounds, to the process for preparation of macrolide based macrocycles, to the pharmaceutical compositions comprising macrolide based macrocycles, and to the use of macrolide based macrocycles as therapeutic agents.
    Type: Application
    Filed: May 8, 2017
    Publication date: January 16, 2020
    Inventors: Andrea FAJDETIC, Maja MATANOVIC SKUGOR, Ivaylo Jivkov ELENKOV, Goran KRAGOL, Mirjana BUKVIC, Zorica MARUSIC ISTUK, Sanja KOSTRUN, Dinko ZIHER, Renata RUPCIC, Kristina BUTKOVIC, Marko DUKSI, Ivana OZIMEC LANDEK, Dijana PESIC, Antun HUTINEC, Milan MESIC, Gordon SAXTY, Visnja POLJAK