Patents by Inventor Dino DiCarlo
Dino DiCarlo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11498071Abstract: Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.Type: GrantFiled: December 20, 2019Date of Patent: November 15, 2022Assignee: The General Hospital CorporationInventors: Mehmet Toner, Dino DiCarlo, Jon F. Edd, Daniel Irimia
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Publication number: 20220080376Abstract: Converting colloidal systems, such as emulsions, dispersions, and suspensions to powders is highly demanded in a myriad of biomedical, pharmaceutical, cosmetic, oil and gas, food, energy, and environmental applications. Handling colloids is typically associated with persistent challenges including bacterial and viral contaminations, lack of terminal sterilization, impaired stability, short shelf life, high processing costs, and difficult packaging and transportation. Current techniques such as freeze-drying and spray-drying have noticeably failed in completely preserving the properties of dispersed phase while removing the continuous phase. The invention disclosed herein provides a new and easy method to convert colloidal systems to powders that are able to readily revive their properties upon resuspension.Type: ApplicationFiled: February 18, 2020Publication date: March 17, 2022Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Amir Sheikhi, Dino DiCarlo, Alireza Khademhosseini
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Patent number: 10941393Abstract: Microfluidic devices and methods for the encapsulation of particles within liquid droplets are disclosed. The new methods and devices form 1-100 picoliter-size monodisperse droplets containing the particles, such as single cells, encapsulated in individual liquid droplets. The particles can be encapsulated in droplets of a fluid by passing a fluid containing the particles through a high aspect-ratio microchannel to order the particles in the fluid, followed by forming the fluid into droplets. The resulting fraction of the liquid droplets with a single particle (e.g., a cell) is higher than the corresponding fraction of single-particle liquid droplets predicted by Poisson statistics.Type: GrantFiled: January 4, 2019Date of Patent: March 9, 2021Assignee: The General Hospital CorporationInventors: Jon F. Edd, Mehmet Toner, Dino DiCarlo, Daniel Irimia
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Publication number: 20200139372Abstract: Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.Type: ApplicationFiled: December 20, 2019Publication date: May 7, 2020Inventors: Mehmet Toner, Dino DiCarlo, Jon F. Edd, Daniel Irimia
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Patent number: 10549278Abstract: Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.Type: GrantFiled: July 30, 2018Date of Patent: February 4, 2020Assignee: The General Hospital CorporationInventors: Mehmet Toner, Dino DiCarlo, Jon F. Edd, Daniel Irimia
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Publication number: 20190276814Abstract: Microfluidic devices and methods for the encapsulation of particles within liquid droplets are disclosed. The new methods and devices form 1-100 picoliter-size monodisperse droplets containing the particles, such as single cells, encapsulated in individual liquid droplets. The particles can be encapsulated in droplets of a fluid by passing a fluid containing the particles through a high aspect-ratio microchannel to order the particles in the fluid, followed by forming the fluid into droplets. The resulting fraction of the liquid droplets with a single particle (e.g., a cell) is higher than the corresponding fraction of single-particle liquid droplets predicted by Poisson statistics.Type: ApplicationFiled: January 4, 2019Publication date: September 12, 2019Inventors: Jon F. Edd, Mehmet Toner, Dino DiCarlo, Daniel Irimia
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Publication number: 20190160465Abstract: Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.Type: ApplicationFiled: July 30, 2018Publication date: May 30, 2019Inventors: Mehmet Toner, Dino DiCarlo, Jon F. Edd, Daniel Irimia
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Patent number: 10174305Abstract: Microfluidic devices and methods for the encapsulation of particles within liquid droplets are disclosed. The new methods and devices form 1-100 picoliter-size monodisperse droplets containing the particles, such as single cells, encapsulated in individual liquid droplets. The particles can be encapsulated in droplets of a fluid by passing a fluid containing the particles through a high aspect-ratio microchannel to order the particles in the fluid, followed by forming the fluid into droplets. The resulting fraction of the liquid droplets with a single particle (e.g., a cell) is higher than the corresponding fraction of single-particle liquid droplets predicted by Poisson statistics.Type: GrantFiled: June 12, 2017Date of Patent: January 8, 2019Assignee: The General Hospital CorporationInventors: Jon F. Edd, Mehmet Toner, Dino DiCarlo, Daniel Irimia
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Publication number: 20180117593Abstract: Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.Type: ApplicationFiled: November 3, 2017Publication date: May 3, 2018Inventors: Mehmet Toner, Dino DiCarlo, Jon F. Edd, Daniel Irimia
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Publication number: 20170342398Abstract: Microfluidic devices and methods for the encapsulation of particles within liquid droplets are disclosed. The new methods and devices form 1-100 picoliter-size monodisperse droplets containing the particles, such as single cells, encapsulated in individual liquid droplets. The particles can be encapsulated in droplets of a fluid by passing a fluid containing the particles through a high aspect-ratio microchannel to order the particles in the fluid, followed by forming the fluid into droplets. The resulting fraction of the liquid droplets with a single particle (e.g., a cell) is higher than the corresponding fraction of single-particle liquid droplets predicted by Poisson statistics.Type: ApplicationFiled: June 12, 2017Publication date: November 30, 2017Inventors: Jon F. Edd, Mehmet Toner, Dino DiCarlo, Daniel Irimia
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Patent number: 9808803Abstract: Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.Type: GrantFiled: May 23, 2016Date of Patent: November 7, 2017Assignee: The General Hospital CorporationInventors: Mehmet Toner, Dino DiCarlo, Jon F. Edd, Daniel Irimia
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Patent number: 9677064Abstract: Microfluidic devices and methods for the encapsulation of particles within liquid droplets are disclosed. The new methods and devices form 1-100 picoliter-size monodisperse droplets containing the particles, such as single cells, encapsulated in individual liquid droplets. The particles can be encapsulated in droplets of a fluid by passing a fluid containing the particles through a high aspect-ratio microchannel to order the particles in the fluid, followed by forming the fluid into droplets. The resulting fraction of the liquid droplets with a single particle (e.g., a cell) is higher than the corresponding fraction of single-particle liquid droplets predicted by Poisson statistics.Type: GrantFiled: June 29, 2015Date of Patent: June 13, 2017Assignee: The General Hospital CorporationInventors: Jon F Edd, Memhet Toner, Dino DiCarlo, Daniel Irimia
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Publication number: 20170080425Abstract: Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.Type: ApplicationFiled: May 23, 2016Publication date: March 23, 2017Inventors: Mehmet Toner, Dino DiCarlo, Jon F. Edd, Daniel Irimia
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Patent number: 9347595Abstract: Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.Type: GrantFiled: July 21, 2014Date of Patent: May 24, 2016Assignee: The General Hospital CorporationInventors: Mehmet Toner, Dino DiCarlo, Jon F. Edd, Daniel Irimia
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Publication number: 20150361414Abstract: Microfluidic devices and methods for the encapsulation of particles within liquid droplets are disclosed. The new methods and devices form 1-100 picoliter-size monodisperse droplets containing the particles, such as single cells, encapsulated in individual liquid droplets. The particles can be encapsulated in droplets of a fluid by passing a fluid containing the particles through a high aspect-ratio microchannel to order the particles in the fluid, followed by forming the fluid into droplets. The resulting fraction of the liquid droplets with a single particle (e.g., a cell) is higher than the corresponding fraction of single-particle liquid droplets predicted by Poisson statistics.Type: ApplicationFiled: June 29, 2015Publication date: December 17, 2015Inventors: Jon F. Edd, Memhet Toner, Dino DiCarlo, Daniel Irimia
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Patent number: 9068181Abstract: Microfluidic devices and methods for the encapsulation of particles within liquid droplets are disclosed. The new methods and devices form 1-100 picoliter-size monodisperse droplets containing the particles, such as single cells, encapsulated in individual liquid droplets. The particles can be encapsulated in droplets of a fluid by passing a fluid containing the particles through a high aspect-ratio microchannel to order the particles in the fluid, followed by forming the fluid into droplets. The resulting fraction of the liquid droplets with a single particle (e.g., a cell) is higher than the corresponding fraction of single-particle liquid droplets predicted by Poisson statistics.Type: GrantFiled: May 26, 2009Date of Patent: June 30, 2015Assignee: The General Hospital CorporationInventors: Jon F. Edd, Mehmet Toner, Dino Dicarlo, Daniel Irimia
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Publication number: 20140326339Abstract: Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.Type: ApplicationFiled: July 21, 2014Publication date: November 6, 2014Inventors: Mehmet Toner, Dino DiCarlo, Jon F. Edd, Daniel Irimia
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Patent number: 8807879Abstract: Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.Type: GrantFiled: September 14, 2012Date of Patent: August 19, 2014Assignee: The General Hospital CorporationInventors: Mehmet Toner, Dino Dicarlo, Jon F. Edd, Daniel Irimia
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Patent number: 8784012Abstract: Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.Type: GrantFiled: May 25, 2012Date of Patent: July 22, 2014Assignee: The General Hospital CorporationInventors: Mehmet Toner, Dino DiCarlo, Jon F. Edd, Daniel Irimia
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Publication number: 20130011210Abstract: Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.Type: ApplicationFiled: September 14, 2012Publication date: January 10, 2013Inventors: Mehmet Toner, Dino Dicarlo, Jon F. Edd, Daniel Irimia