Abstract: The present disclosure provides a dose collection apparatus that comprises a first conduit comprising a first inlet port and a first fluid flow path and a second conduit comprising a second inlet port and a second fluid flow path.

Abstract: In an embodiment, the present invention is an apparatus, configured to collect emitted sample dose from a drug delivery device, wherein the sample dose is an aerosol, wherein the apparatus comprises a collection assembly and a removable plunger.

Abstract: In an embodiment, the present invention is an apparatus, configured to collect emitted sample dose from a drug delivery device, wherein the sample dose is an aerosol, wherein the apparatus comprises a collection assembly and a removable plunger.

Abstract: In an embodiment, the present invention is an apparatus, configured to collect emitted sample dose from a drug delivery device, wherein the sample dose is an aerosol, wherein the apparatus comprises a collection assembly and a removable plunger.

Abstract: In an embodiment, the present invention is an apparatus, configured to collect emitted sample dose from a drug delivery device, wherein the sample dose is an aerosol, wherein the apparatus comprises a collection assembly and a removable plunger.

Abstract: In an embodiment, the present invention is an apparatus, configured to collect emitted sample dose from a drug delivery device, wherein the sample dose is an aerosol, wherein the apparatus comprises a collection assembly and a removable plunger.

Abstract: In an embodiment, the present invention is an apparatus, configured to collect emitted sample dose from a drug delivery device, wherein the sample dose is an aerosol, wherein the apparatus comprises a collection assembly and a removable plunger.

Abstract: Direction of material emitted from orifices is directly related to the effectiveness of spray devices to deliver the material to an intended location area. Improper emission direction results in material, such as medication, paint, or fuel, not reaching its intended target and causes cascading effects, such as improper patient dosing, compromised patient relief, waste, poor target coverage, missed target penetration, poor engine performance, and other safety/performance problems. An apparatus for inspecting operation of an orifice according to an example embodiment measures actual material emission direction relative to an expected material emission direction determined as a function of position and orientation of an orifice. The apparatus may confirm whether the emission direction is within an expected emission direction and accepted tolerance range. Through use of the apparatus, accurate screening of production products can be performed efficiently and manufacturing defects can be diagnosed and eliminated.

Abstract: An assembly that provides operational information about operation of a device, such as a nasal spray pump or metered dose inhaler. A linkage adapted to extend between a mounting assembly, connected to a stationary part of the device, and an adapter assembly, connected to a movable part of the device, is in operational relationship with a transducer to enable the transducer to indicate a mechanical relationship between the movable and stationary parts of the device corresponding to the operation of the device. A data collection and processing system may be connected to the transducer for determining information that may be used to program an automated actuation system.

Abstract: A spray data acquisition system includes a spray pump actuator that is capable of providing a pumping force to a pumping device to generate an aerosol spray plume along a spray axis. The system also includes an illumination device that illuminates the aerosol spray plume along at least one first geometric plane that intersects the aerosol spray plume. The system further includes an imaging device that acquires data representative of an interaction between the illumination and the aerosol spray plume along at least one geometric plane.

Abstract: An assembly that provides operational information about operation of a spray device, such as a nasal spray pump or metered dose inhaler. A linkage adapted to extend between a mounting assembly, connected to a stationary part of the spray device, and an adapter assembly, connected to a movable part of the spray device, is in operational relationship with a transducer to enable the transducer to indicate a mechanical relationship between the movable and stationary parts of the spray device corresponding to the operation of the spray device. A data collection and processing system may be connected to the transducer for determining information that may be used to program an automated actuation system.

Abstract: A spray data acquisition system includes a spray pump actuator that is capable of providing a pumping force to a pumping device to generate an aerosol spray plume along a spray axis. The system also includes an illumination device that illuminates the aerosol spray plume along at least one first geometric plane that intersects the aerosol spray plume. The system further includes an imaging device that acquires data representative of an interaction between the illumination and the aerosol spray plume along at least one geometric plane.

Abstract: A system for actuating a spray pump assembly comprises a reference platform, a motor, a drive transmission, a spray pump holder, a force coupler, a force transducer, and a system controller. The motor receives a power and control input, and produces a rotary drive output. The drive transmission receives the rotary drive output and produces a linear drive output. The spray pump holder secures the spray pump assembly. The force coupler couples the linear drive output to the spray pump, and applies a force to the spray pump. The force transducer produces a force signal proportional to the force applied to the spray pump. The system controller receives a set of test inputs and provides the control input to the motor as a function of the set of test inputs. The system actuates the spray pump mechanism according to an actuation profile defined by the set of test inputs.

Abstract: A spray data acquisition system includes a pumping device responsive to an applied force to generate an aerosol spray plume along a spray axis. The system further includes a spray pump actuator that is capable of controlling the pumping force and the duration of the aerosol spray plume produced by the pumping device. The system also includes an illumination device that illuminates the aerosol spray plume along at least one first geometric plane that intersects the aerosol spray plume. The system further includes an imaging device that acquires data representative of an interaction between the illumination and the aerosol spray plume along at least one geometric plane.

Abstract: An automated system for testing a spray pump assembly includes a system computer, a robotic handler, holder tray, actuator, and analytical balance. The system computer issues commands to the robotic handler to handle and to transport spray pump assemblies, collection vessels, waste collectors, and nozzle tip dabbers. The robotic handler includes an electromechanical gripper capable of handling objects of varying sizes and sensing contact between gripped objects and another object. The robotic handler may also perform shaking functions. The holder tray, actuator, and other system elements may include sensors for detecting the presence of testing objects. The spray pump assembly may include a collet with a tapered and threaded aperture for securing the collet to a spray pump. The system may further include an elevator assembly for positioning and transporting the actuator (while holding a spray pump assembly) between a first testing area and a second testing area.

Abstract: A method for servicing companies associated with a spray device operating under guidelines of a regulatory body includes capturing in vitro actuation data associated with operation of the spray device and distributing the data to a company associated with an aspect of the spray device. The company may use the data for testing the spray device to ensure continued compliance with prior approval of the spray device by the regulatory body. The method may also include converting the data to parameters and distributing the parameters. Capturing the in vitro actuation data may include sorting the data based on in vitro age groups. Distributing the data may include providing the data in a format executable by an automated actuation system. The company receiving the data may be a drug development company, spray device manufacturer, or testing service. The regulatory body may be the Food and Drug Administration (FDA).

Abstract: A system for actuating a spray pump assembly comprises a reference platform, a motor, a drive transmission, a spray pump holder, a force coupler, a force transducer, and a system controller. The motor receives a power and control input, and produces a rotary drive output. The drive transmission receives the rotary drive output and produces a linear drive output. The spray pump holder secures the spray pump assembly. The force coupler couples the linear drive output to the spray pump, and applies a force to the spray pump. The force transducer produces a force signal proportional to the force applied to the spray pump. The system controller receives a set of test inputs and provides the control input to the motor as a function of the set of test inputs. The system actuates the spray pump mechanism according to an actuation profile defined by the set of test inputs.

Abstract: A method of and system for analyzing image data representative of a sequential set of images of a spray plume, each of the images being representative of a density characteristic of the spray plume (i) along a geometric plane that intersects the spray plume, and (ii) at a predetermined instant in time, that in one aspect comprises sequentially displaying the set of images so as to exhibit a time evolution of the spray plume along the geometric plane. The invention may further integrate the set of images so as to exhibit a time-average representation of the images. In one embodiment, the invention comprises a general purpose computer executing software that receives and sequentially displays the set of images so as to exhibit a time evolution of the spray plume along the geometric plane, and provides a user interface for measuring one or more spray plume parameters associated with the spray plume within one or more of the images.

Abstract: A spray data acquisition system includes a pumping device responsive to an applied force to generate an aerosol spray plume along a spray axis. The system further includes a spray pump actuator that is capable of controlling the pumping force and the duration of the aerosol spray plume produced by the pumping device. The system also includes an illumination device that illuminates the aerosol spray plume along at least one first geometric plane that intersects the aerosol spray plume. The system further includes an imaging device that acquires data representative of an interaction between the illumination and the aerosol spray plume along at least one geometric plane.

Abstract: A system for actuating a spray pump assembly comprises a reference platform, a motor, a drive transmission, a spray pump holder, a force coupler, a force transducer, and a system controller. The motor receives a power and control input, and produces a rotary drive output. The drive transmission receives the rotary drive output and produces a linear drive output. The spray pump holder secures the spray pump assembly. The force coupler couples the linear drive output to the spray pump, and applies a force to the spray pump. The force transducer produces a force signal proportional to the force applied to the spray pump. The system controller receives a set of test inputs and provides the control input to the motor as a function of the set of test inputs. The system actuates the spray pump mechanism according to an actuation profile defined by the set of test inputs.