Patents by Inventor Dinos P. Santafianos

Dinos P. Santafianos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes and intermediates for preparing anti-cancer compounds
    Patent number: 6476040
    Abstract: The present invention relates to methods and intermediates for preparing compounds of the formula 1 and the pharmaceutically acceptable salts and solvates thereof, as well as structurally related compounds, wherein R1, R2 and R15 are as defined herein. The foregoing compounds are useful in the treatment of hyperproliferative disorders, such as cancers, in mammals.
    Type: Grant
    Filed: March 30, 2000
    Date of Patent: November 5, 2002
    Assignees: Pfizer Inc., Pfizer Products Inc.
    Inventors: Timothy Norris, Dinos P. Santafianos, Richard S. Lehner
  • 4-arylamino-benzopyran and related compounds
    Patent number: 5837702
    Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is alkyl, Y is a single bond, --CH.sub.2 --, --C(O)--, --O--, --S-- or --N(R.sup.8)-- where R.sup.8 is hydrogen, alkyl, haloalkyl, aryl, arylalkyl, cycloalkyl or (cycloalkyl)alkyl, and R.sup.1 to R.sup.7 are as defined herein. These compounds have potassium channel activating activity and are useful, therefore for example, as cardiovascular agents.
    Type: Grant
    Filed: August 30, 1994
    Date of Patent: November 17, 1998
    Assignee: Bristol-Myers Squibb Co.
    Inventors: George C. Rovnyak, Karnail S. Atwal, Dinos P. Santafianos, Charles Z. Ding
  • Aryl and heterocyclic substituted propenamide derivatives
    Patent number: 5453421
    Abstract: Novel compounds useful, for example, for the treatment of ischemic conditions and arrhythmia are disclosed. The compounds have the formula ##STR1## wherein X is oxygen or sulfur and the R groups are as defined herein.
    Type: Grant
    Filed: August 12, 1993
    Date of Patent: September 26, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karnail S. Atwal, Syed Z. Ahmed, Dinos P. Santafianos
  • Nitrogen-substituted mevinic acid derivatives useful as HMG-CoA reductase inhibitors
    Patent number: 5369123
    Abstract: Novel nitrogen-substituted mevinic acid derivatives which inhibit the activity of HMG-CoA reductase. Pharmaceutical compositions, and methods of use for the treatment or prevention of hypercholesterolemia, atherosclerosis, hyperlipoproteinaemia and hyperlipidemia are provided, as are novel methods for preparation and intermediate compounds.
    Type: Grant
    Filed: October 9, 1992
    Date of Patent: November 29, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Dinos P. Santafianos, Kathleen M. Poss, Eric M. Gordon, Peggy J. McCann
  • Sulfur-substituted mevinic acid derivatives
    Patent number: 5264455
    Abstract: X is hydrogen or --S(O).sub.m --R.sup.1 and Y is hydrogen or S(O).sub.n --R.sup.2, except that X and Y are not both hydrogen, or one of X and Y is --S--alkyl--SH and the other is hydrogen; ##STR2## and the remaining symbols are as defined in the specification.
    Type: Grant
    Filed: July 1, 1991
    Date of Patent: November 23, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ravi K. Varma, Jeffrey O. Saunders, Sam T. Chao, Eric M. Gordon, Dinos P. Santafianos