Patents by Inventor Dinshaw Patel

Dinshaw Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210155625
    Abstract: 1-(3,4-Dihydro-1H-pyrido[4, 3-b]indol-2(5H)-yl)-2-hydroxyethanones are disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.
    Type: Application
    Filed: February 5, 2019
    Publication date: May 27, 2021
    Applicants: The Rockefeller University, Memorial Sloan-Kettering Cancer Center
    Inventors: Lodoe LAMA, Thomas TUSCHL, Daisuke TOMITA, Dinshaw PATEL, J. Fraser GLICKMAN, Taku KAMEI, Michael MILLER, Yasutomi ASANO, Rei OKAMOTO, Shogo HASHIZUME, Jumpei AIDA, Toshihiro IMAEDA, Mayako MICHINO, Takanobu KUROITA
  • Patent number: 10961289
    Abstract: The present invention relates to small molecules interfering with the conformational space of the TONSL ARD occupied by the histone H4 tail. These small molecules targets the binding pocket of TONSL encompassing the H4 residues K12-R23 and act by preventing or disrupting the binding of the H4 tail K12-R23 with the TONSL ARD via direct competition or via allosteric disruption of the binding pocket.
    Type: Grant
    Filed: November 29, 2019
    Date of Patent: March 30, 2021
    Assignees: The University of Copenhagen, Memorial Sloan-Kettering Cancer Center
    Inventors: Anja Groth, Giulia Saredi, Hongda Huang, Colin Hammond, Dinshaw Patel
  • Publication number: 20200148732
    Abstract: The present invention relates to small molecules interfering with the conformational space of the TONSL ARD occupied by the histone H4 tail. These small molecules targets the binding pocket of TONSL encompassing the H4 residues K12-R23 and act by preventing or disrupting the binding of the H4 tail K12-R23 with the TONSL ARD via direct competition or via allosteric disruption of the binding pocket.
    Type: Application
    Filed: November 29, 2019
    Publication date: May 14, 2020
    Inventors: Anja Groth, Giulia Saredi, Hongda Huang, Colin Hammond, Dinshaw Patel
  • Publication number: 20180282383
    Abstract: The present invention relates to small molecules interfering with the conformational space of the TONSL ARD occupied by the histone H4 tail. These small molecules targets the binding pocket of TONSL encompassing the H4 residues K12-R23 and act by preventing or disrupting the binding of the H4 tail K12-R23 with the TONSL ARD via direct competition or via allosteric disruption of the binding pocket. The present inventors have identified and solved the structure of a histone reader domain of TONSL termed the ARD (ankyrin repeat domain).
    Type: Application
    Filed: September 30, 2016
    Publication date: October 4, 2018
    Inventors: Anja Groth, Giulia Saredi, Hongda Huang, Colin Hammond, Dinshaw Patel
  • Patent number: 9840533
    Abstract: The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof; methods of using the compounds as described herein for treating cancer, and immune disease, disorders, or conditions; methods of using the compounds as described herein for modulating cGAS and STING; and methods of designing or characterizing a cGAS modulator.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: December 12, 2017
    Assignees: Memorial Sloan Kettering Cancer Center, Rutgers, The State University of New Jersey, The Rockefeller University, University of Bonn
    Inventors: Dinshaw Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Publication number: 20160068560
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Application
    Filed: April 29, 2014
    Publication date: March 10, 2016
    Applicant: Memorial Sloan Kettering Cancer Center
    Inventors: Dinshaw Patel, Thomas Tuschl, Manuel Ascano, JR., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Publication number: 20110237549
    Abstract: Provided is a computer model generated from a data array, computer readable storage media encoded with the model, and computers comprising the model, wherein the model is derived from atomic structure coordinates of a FMN riboswitch or a lysine riboswitch. Further provided is a pharmacophore having a spatial arrangement of atoms defined by the binding pocket identified in the model, along with a compound defined by the pharmacophore. Also further provided are methods for rational drug design based on the atomic structure data, and compounds identified by the rational drug design process.
    Type: Application
    Filed: March 27, 2009
    Publication date: September 29, 2011
    Applicant: MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: Dinshaw Patel, Alexander Serganov, Lili Huang
  • Patent number: 6086751
    Abstract: TAN containing oils, e.g., crudes, are treated by flashing to remove substantially all of the water therefrom, thermally treating the recovered liquid to reduce the naphthenic acid content thereof, and re-combining light gases recovered from the flashing step with the treated liquid.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: July 11, 2000
    Assignee: Exxon Research and Engineering Co
    Inventors: Marty G. Bienstock, John G. Matragrano, Rutton Dinshaw Patel, Roby Bearden, Jr.