Abstract: This disclosure provides compounds, compositions and methods for one or more of: inhibiting the growth of a diseased cell mediated by GNAS activity; inhibiting the growth of a cancer cell, inhibiting the growth of a cancer cell mediated by GNAS activity, or assaying for inhibitory activity of a compound or pharmaceutical activity of a diseased cell in a subject in need thereof by administering to the subject an effective amount of a compound or composition of this disclosure. Also provided are compounds, compositions and methods for treating cancer in a patient in need thereof, by administering to the subject an effective amount of a compound or composition as disclosed herein.

Abstract: The present invention relates generally to methods of synthesis of vinaxanthone and xanthofulvin, novel analogs, and methods of use thereof.

Abstract: The present invention provides a method for converting an aromatic hydrocarbon to a phenol by providing an aromatic hydrocarbon comprising one or more aromatic C—H bonds and one or more activated C—H bonds in a solvent; adding a phthaloyl peroxide to the solvent; converting the phthaloyl peroxide to a di-radical; contacting the di-radical with the one or more aromatic C—H bonds; oxidizing selectively one of the one or more aromatic C—H bonds in preference to the one or more activated C—H bonds; adding a hydroxyl group to the one of the one or more aromatic C—H bonds to form one or more phenols; and purifying the one or more phenols.

Abstract: The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.