Abstract: An aerosol-generating system is provided, including: a cartridge assembly including an outer housing defining a mouthpiece having an air outlet, a cartridge having upstream and downstream ends and including first and second compartments, a mixing chamber extending between a downstream end of the cartridge and the mouthpiece air outlet, and a ventilation air inlet downstream of the cartridge; and an aerosol-generating device including a device inner housing defining a device cavity, an electrical heater configured to heat the cartridge, a power supply, a controller configured to control a supply of electrical power to the electric heater, and a device outer housing, such that when the upstream end of the cartridge is received within the device cavity, a first part of a downstream edge of the device outer housing abuts a first part of an upstream edge of the cartridge assembly outer housing to form a system outer housing.

Abstract: An aerosol-generating system is provided, including: a cartridge assembly including an outer housing defining a mouthpiece having an air outlet, a cartridge having upstream and downstream ends and including first and second compartments, a mixing chamber extending between a downstream end of the cartridge and the mouthpiece air outlet, and a ventilation air inlet downstream of the cartridge; and an aerosol-generating device including a device inner housing defining a device cavity, an electrical heater configured to heat the cartridge, a power supply, a controller configured to control a supply of electrical power to the electric heater, and a device outer housing, such that when the upstream end of the cartridge is received within the device cavity, a first part of a downstream edge of the device outer housing abuts a first part of an upstream edge of the cartridge assembly outer housing to form a system outer housing.

Abstract: A sachet of aerosol-forming substrate for electrically heated aerosol-generating device is provided, including a porous container; and an aerosol-forming substrate within the container, the substrate having a porosity of between about 0.2 and about 0.35, the porosity being the volume fraction of void space within the container. An electrically heated aerosol-generating system is also provided, including a sachet of aerosol-forming substrate; and an aerosol-generating device, the device including an outer housing having a cavity configured to receive the sachet, and an electrical heater including at least one heating element configured to heat the sachet in the cavity to generate an aerosol from the aerosol-forming substrate for inhalation by a user.

Abstract: A smoking article having a proximal end and a distal end is provided, including a combustible heat source disposed at the distal end; an aerosol-forming substrate downstream of the combustible heat source; a mouthpiece downstream of the aerosol-forming substrate and disposed at the proximal end; and a tubular element, which is slideable from a first position towards the distal end to a second position. In the second position, the tubular element at least partially extends over the combustible heat source and is configured to reduce the air supply to the combustible heat source. The tubular element is configured to modify a heat output of the combustible heat source, and to control a resistance-to-draw of the smoking article by selectively covering air inlets.

Abstract: A sachet of aerosol-forming substrate for electrically heated aerosol-generating device is provided, including a porous container; and an aerosol-forming substrate within the container, the substrate having a porosity of between about 0.2 and about 0.35, the porosity being the volume fraction of void space within the container. An electrically heated aerosol-generating system is also provided, including a sachet of aerosol-forming substrate; and an aerosol-generating device, the device including an outer housing having a cavity configured to receive the sachet, and an electrical heater including at least one heating element configured to heat the sachet in the cavity to generate an aerosol from the aerosol-forming substrate for inhalation by a user.

Abstract: A smoking article having a proximal end and a distal end is provided, including a combustible heat source disposed at the distal end; an aerosol-forming substrate downstream of the combustible heat source; a mouthpiece downstream of the aerosol-forming substrate and disposed at the proximal end; and a tubular element slideable from a first position towards the distal end to a second position. In the second position, the slideable element at least partially extends over the combustible heat source and is configured to reduce the air supply to the combustible heat source. The tubular element is configured to modify a heat output of the combustible heat source, and to control a resistance-to-draw of the smoking article by selectively covering air inlets.

Abstract: The present invention relates to non-mammalian ?-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian ?-1,4-galactosyltransferases and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian ?-1,4-galactosyltransferases.

Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTIII that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.

Abstract: The present invention relates to non-mammalian ?-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian ?-1,4-galactosyltransferases and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian ?-1,4-galactosyltransferases.

Abstract: The invention is directed to methods for optimizing glycan processing in organisms (and in particular, plants) so that a glycoprotein having complex type bi-antennary glycans and thus containing galactose residues on both arms and which are devoid of (or reduce in) xylose and fucose can be obtained. The invention is further directed to said glycoprotein obtained and host system comprising said protein.

Abstract: The present invention relates to non-mammalian ?-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian ?-1,4-galactosyltransferase and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian ?-1,4-galactosyltransferases.

Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTIII that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.

Abstract: The present invention is directed to targeting genes and genomes, modifying the activity of enzymes and protein expression in plants. In particular, the present invention relates to methods for reducing the activity of one or more endogenous glycosyltransferases such as N-acetylglucosaminyltransferase, ?(1,2)-xylosyltransferase and a(1,3)-fucosyl-transferase in a plant cell and to plants obtained by said method.

Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTIII that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.

Abstract: The present invention relates to non-mammalian ?-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian ?-1,4-galacto-syltransferase and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian ?-1,4-galactosyltransferases.

Abstract: The present invention relates to non-mammalian ?-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian ?-1,4-galacto-syltransferase and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian ?-1,4-galactosyltransferases.

Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTIII that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.

Abstract: The invention is directed to methods for optimizing glycan processing in organisms (and in particular, plants) so that a glycoprotein having complex type bi-antennary glycans and thus containing galactose residues on both arms and which are devoid of (or reduce in) xylose and fucose can be obtained. The invention is further directed to said glycoprotein obtained and host system comprising said protein.

Abstract: The invention is directed to methods for optimizing glycan processing in organisms (and in particular, plants) so that a glycoprotein having complex type bi-antennary glycans and thus containing galactose residues on both arms and which are devoid of (or reduce in) xylose and fucose can be obtained. The invention is further directed to said glycoprotein obtained and host system comprising said protein.

Abstract: The present invention relates to non-mammalian ?-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian ?-1,4-galacto-syltransferase and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian ?-1,4-galactosyltransferases.